Patentai

A method for screening the polymer-degrading enzymes

2025-04-24T12:33:46+03:00

The present invention is provided methods of screening for polymer-degrading enzymes and microorganisms, enzymes or microorganisms variants which display increased activity towards native or/and synthetic polymers.

Inventors: Rolandas Meškys, Nina Urbelienė, Renata Gasparavičiūtė, Renata Gudiukaitė.

Jurisdiction: EP

Optical frequency converter based on III-n semiconductors

2025-02-04T09:58:50+02:00

Inventors: Roland Tamašiūnas, Raimondas Petruškevičius, Vitalijus Bikbajevas, Darius Kežys, Arūnas Kadys

Jurisdiction: EP

Microcapsules comprising biological samples, and methods for use of same

2025-02-04T09:52:02+02:00

The present invention concerns a method of performing one or more reactions on a biological entity, the method comprising: (i) isolating the biological entity in a microcapsule comprising a core and a semi-permeable shell; and (ii) performing the one or more reactions on the biological entity in the microcapsule.

Inventors: Linas Mažutis, Greta Leonavičienė

Jurisdiction: EP

Link to esapacenet

A novel RNA-programmable system for targeting polynucleotides

2025-02-04T09:44:49+02:00

The present invention concerns a method for cleaving polynucleotides with an effector complex comprising an RNA and a protein comprising a TnpB protein, and related methods and products.

Inventors: Virginijus Šikšnys, Tautvydas Karvelis.

Jusrisdiction: EP, US, KR, JP.

Link to esapacenet

Hydrolases and uses thereof

2025-02-04T09:31:32+02:00

The present invention is provided hydrolases originating from prokaryotic, archaea and eukaryotic cells, capable of regioselectively converting N4-acylcytidine, N4-alkylcytidine, N4-carboxycytidine, S4-alkylthiouridine and O4-alkoxyuridine derivatives to uridine derivatives. The present disclosure provides using these polypeptides in the processes: 1) for making chemical uridine derivatives from N4-acylcytidines, N4-alkylcytidines, N4-carboxycytidine, S4-alkylthiouridines and O4-alkoxyuridine compounds; 2) for making pyrimidine compounds such as intermediates in the production active pharmaceutical drugs; 3) for the prodrug activation; 4) in combination with N4-acylcytidines, N4-alkylcytidines, S4-alkylthiouridines and O4-alkoxyuridines for the selection of enzymes.

Inventors: Rolandas Meškys, Nina Urbelienė, Daiva Tauraitė, Matas Tiškus, Viktorija Preitakaitė

Jurisdiction: EP, LT

Method for estimation of crystal periodic poling quality

2025-02-04T09:16:46+02:00

A non-destructive method for estimation of periodically poled crystal poling quality in the whole crystal volume, at small periods, such as significantly smaller than 10 µm, with high precision at periods equal or less than periods of poling of the periodically poled crystal using a nonlinear process based periodic poling quality measurement setup. The method is also applicable to fan-out type periodically poled crystals to estimate periodic poling quality in the whole volume where poling period should be equal.

Inventors: Julius Vengelis, Jonas Banys, Jokūbas Pimpė.

Jurisdiction: EP

Ablation of materials with double time-separated laser pulses

2025-02-03T14:48:20+02:00

Laser ablation and processing of materials is applied in various applications ranging from consumer electronics to specific medical applications. Ultrashort laser pulses used for high-quality processing of transparent materials, are not enough efficient as the laser energy is absorbed via multiphoton absorption, and much of energy is lost. Meanwhile, long pulses (of nanosecond range) rely on heating intrinsic free electrons which may be distributed unevenly in the material, and in combination with the long duration, the heat-affected areas are evident in the processed material. The present invention discloses a method and system of laser ablation with improved efficiency, employing focused femtosecond/picosecond dual-pulse irradiation. The femtosecond pulse first excites local free electrons of the material into the conduction band, and then the excited electrons are heated and multiplied via impact absorption of the subsequent picosecond pulse, resulting in efficient ablation of the material.

Inventors: Vytautas Jukna; Simas Butkus; Dangirdas Šulnius

Jurisdiction: EP.

Inhibition of protein amyloid aggregation using fluorinated benzenesulfonamides

2024-01-31T09:56:39+02:00

This invention teaches a class of fluorinated benzensulfonamides of general structure I, as shown:

which are useful for inhibiting protein amyloid aggregation. The compounds taught can be used in pharmaceutical compositions in effective amounts to treat illnesses that result from protein amyloid aggregation.

Inventors: Daumantas Matulis; Andrius Sakalauskas; Virginija Dudutienė; Mantas Žvirblis; Mantas Žiaunys; Vytautas Smirnovas

Jurisdiction: US, EP

A compact lamp

2023-12-15T14:35:38+02:00

The compact lamp (1) consists of at least one light source (2), at least one focusing lens (3), a specially shaped secondary lens (4) with a saddle-shaped output surface, at least one light transmitting element (6), a battery holding chamber (8) with an electrical control circuit (9), which is connected to a button (11) for control of the lamp source via a magnetic contact (10). Some of these elements are placed inside the lamp housing, which is mounted on an end of a handlebar or another suitable lighting device, and some other elements, including the battery (7) and the magnetic control circuit, are installed inside the handlebar tube or the housing of the lighting device. The compact optical layout allows obtaining a beam, which is sharply limited in the vertical plane and sufficiently wide in the horizontal plane and is suitable for daytime running lamps, night headlamps or position lights.

Inventors: Saulius Rudys, Robertas Grigalaitis, Jūras Banys.

Jurisdiction: LT, US, EP

Monoclonal antibodies against common carp beta-enolase

2023-08-23T13:46:25+03:00

The invention belongs to the field of protein biotechnology. New monoclonal antibodies against carp β-enolase and hybridoma cells producing them are described herein. Monoclonal antibodies can be used to detect carp and other fish proteins in foods, and to identify commercial carp extracts.

Inventors: Gintautas Žvirblis, Aistė Sližienė, Milda Plečkaitytė, Mindaugas Zaveckas

Jurisdiction: LT, EP

Hybrid multi-layer sensor and method for large fluence dosimetry and fluxmetry

2023-08-23T13:42:01+03:00

This invention discloses a hybrid multi-layer sensor (1) and methods for large fluence dosimetry and fluxmetry by using this sensor. The sensor (1) comprises scintillator sensors (2) and a photosensor (4) operating in the pulse-mode as well as in DC-mode, which is separated from the photosensor (2) by the visible spectrum filter (3) made of large conductivity Si-layer. During dosimetry and fluxmetry, the scintillator (2) and the photosensor (4) are scanned by external apparatuses - a fiber-coupled spectrophotometer (8) and the microwave needle-tip antenna connected to a microwave detection system (7). The discrimination of particle species and the particle energies is performed by correlating signals of the scintillator (2) spectrum structure and the microwave probed photoconductivity amplitude and decay lifetime, where the multi-layered scintillator (2) and the photosensor (4) act as the complementary detectors. This multi-layer sensor (1) is designed for contactless dosimetry and fluxmetry, and is complemented with reading apparatuses (7, 8, 14) and irradiation measurement methods for monitoring of harsh radiation facilities and control of mixed particle beams in nuclear reactors, in storages of nuclear fuel waste, in large particle accelerators and neutron spallators.

Inventors: Eugenijus Gaubas, Tomas Čeponis, Laimonas Deveikis, Jevgenij Pavlov, Vytautas Rumbauskas

Jurisdiction: LT, EP

Magnetinis reliatyvistinių elektringųjų dalelių analizatorius

2023-08-23T13:39:39+03:00

Pasiūlymas yra iš branduolinės fizikos matavimo prietaisų inžinerijos srities ir gali būti panaudotas reliatyvistinių elektringųjų dalelių aptikimui, jų šaltinio erdvinės padėties (krypties) nustatymui ir dalelių energetinio spektro matavimams, bei pritaikytas kosminiuose palydovuose tyrinėti reliatyvistinių elektronų srautus ir jų dinamiką Žemės radiacinėse juostose. Pasiūlytuose reliatyvistinių dalelių analizatoriuose vienalytis magnetinis kreipiantysis laukas yra sutelktas stačiojo apskritojo cilindro arba puscilindrio formos srityje, o analizatorių židiniai yra įrengti apskritojo cilindro šoniniame paviršiuje arba 90° fokusavimo plokštumoje. Pasiūlyti apskritojo cilindro paviršiaus ir 90° fokusavimo plokštumos magnetiniai reliatyvistinių dalelių analizatoriai, pasižymi mažesniais gabaritais ir mase, platesniu matuojamųjų energijų spektru, didesniu kanalų išdėstymo tankiu bei matavimų jautriu ir geresniu dalelių kampinio pasiskirstymo tikslumu.

Išradėjai: Eugenijus Gaubas, Tomas Čeponis, Vidas Kalesinskas, Vytautas Rumbauskas, Laimonas Deveikis

Jurisdikcija: LT

Dvigubo atsako jonizuojančios spinduliuotės detektorius ir matavimo būdas

2023-08-23T12:59:06+03:00

Pasiūlymas yra iš jonizuojančiosios spinduliuotės matavimų srities ir gali būti naudojamas spinduliuotės srauto, pėdsako ir įtėkio (suminės dozės) parametrų matavimams, sinchroniškai kontroliuojant antrinių (ir tretinių) krūvininkų porų dreifo srovės sandų ir spinduliuote indukuotos liuminescencijos intensyvumo kitimus, siekiant įvertinti spinduliuotės spektrą, stabdymo ilgį ir spinduliuotės pluoštelio skerspjūvio parametrus, ir yra tinkamas jonizuojančiųjų spinduliuočių poveikių kontrolei tiek apšvitos metu, tiek po apšvitų. Pasiūlyti penkių konstrukcijų juosteliniai detektoriai, formuojami plačiatarpių puslaidininkių pusiau-izoliuojančių medžiagų mezastruktūrų pagrindu, sudarant ominius/blokuojančius bei Šotkio kontaktus, p-n sandūras, ir šviesolaidinių zondų liniuotes, sinchroniškai matuojant optinio ir elektrinio atsako signalus. Aprašyti jonizuojančiųjų spinduliuočių detektavimo būdai, matavimų režimų esminiai bruožai ir paskirtis, pasitelkiant pasiūlytų konstrukcijų detektorius.

Išradėjai: Eugenijus Gaubas, Tomas Čeponis, Domas Paipulas, Česlovas Pavasaris, Vidas Kalesinskas

Jurisdikcija: LT

Berlyno mėlynojo pasluoksnio ant titano pagrindo formavimo metodai ir jų taikymas gliukozės biologiniuose jutikliuose

2023-08-23T12:51:13+03:00

Šis išradimas aprašo biologinių jutiklių, kurie gali būti panaudojami gliukozės kiekio nustatymui mėginiuose, gamybos būdus. Šiuose biojutikliuose naudojamos titano plokštelės padengtos Berlyno mėlynojo sluoksniu, prie kurio prijungiamas polipirolo inkaras arba tiesiogiai nusodinamas fermentas, leidžiantis aptikti mėginyje esančią analitę. Gaminant gliukozės biojutiklius, šis fermentas yra gliukozės oksidazė. Šie biojutikliai pranašesni tuo, kad jų veikimui naudojamas žemas elektrodo potencialas.

Išradėjai: Almira Ramanavičienė, Arūnas Ramanavičius, Aušra Valiūnienė, Urtė Samukaitė-Bubnienė, Povilas Virbickas

Jurisdikcija: LT

Radijo dažnio signalų segmentavimo būdas

2023-08-23T12:40:07+03:00

Būdas pagal išradimą yra įgyvendinamas naudojant įprastinę automatinio atpažinimo sistemą su palydoviniu sekimu, apimančią laivybos keliais plaukiojančių laivų signalų siųstuvus ir imtuvus, tinkama orbita skriejantį palydovą, kuris gali priimti laivų siųstuvų siunčiamus signalus.Skaitmeniniame žemėlapyje žemės paviršius yra padalinamas į zonas, kurių plotis yra apytiksliai 2/3 palydovo apžvalgos lauko pločio (zonos plotis turi būti toks, kad į palydovo apžvalgos lauką nepatektų dvi vienodos pazonės), o zonos yra padalinamos į pazones, kurių plotis yra lygus maksimaliam ryšio atstumui tarp laivų. Tokiu būdu padalinto žemėlapio kiekvienoje iš zonų yra suformuojamas pasikartojantis pazonių skaičius. Tokia zonų ir pazonių struktūra yra suformuojama kaip skaitmeninis žemės paviršiaus žemėlapis, kuris yra įvedamas į automatinio atpažinimo sistemą. Esant tokiam padalinimui, paketų laiko intervalų rinkinys yra išdalinamas kiekvienos zonos pazonėms po lygiai arba skirtingomis proporcijomis. Kiekvieno laivo, esančio vienoje iš pazonių, automatinio atpažinimo sistemos laivo dalis priskiria laiko intervalą iš toje pazonėje, arba kitoje artimiausiose pazonėje, esančio laiko intervalų rinkinio. Tokiu būdu yra išvengiama automatinio atpažinimo sistemos signalų persidengimo juos priimančiame palydove.

Išradėjai: Saulius Rudys, Jūras Banys, Robertas Grigalaitis, Vytautas Jonkus, Jevgenij Krivochiza, Šarūnas Svirskas, Džiugas Jablonskas, Jurgis Aleksandravičius

Jurisdikcija: LT

Method for remotely interfering with electronic equipment

2023-08-23T11:33:03+03:00

The method of remotely interfering with electronic equipment of a target having electronic equipment, comprising generating of more than one signal, and emitting it through one or more antennas. One or more antennas emit signals of different frequencies that reach the target unchanged and excite non-linear frequency mixing processes in the target electronic components that generate at least one signal whose frequency differs from the frequencies of the signals emitted from one or more antennas and corresponds to the operating frequencies of the target electronic equipment.

Inventors: Saulius Rudys; Paulius Ragulis; Rimvydas Aleksiejūnas

Jurisdiction: LT, PCT

A system for visual data analysis of ultrasound examinations with and without a contrast medium, for early automated diagnostics of pancreatic pathologies

2023-08-23T11:28:17+03:00

We present a system and method for analysis of image and data of ultrasound and ultrasound with contrast medium of human pancreatic tissues to automatically diagnose acute pancreatitis of the pancreas and identify pancreatic non-viable tissues at an early stage. The system consists of a diagnostic ultrasound system with specialized software for contrast studies (ultrasound) for in vivo ultrasound examinations of human internal organs, recording reflected ultrasound signals from pancreatic tissues (without contrast material and when contrast material is injected) and an image and data processing algorithm with artificial intelligence (neural network) elements providing a diagnostic estimate of a recommendatory nature.

Inventors: Aistė Kielaitė-Gulla; Renaldas Raišutis; Kęstutis Strupas; Artūras Samuilis

Jurisdiction: LT, US, EP

Multistage parametric light amplification method and multistage amplifier

2023-08-23T10:19:01+03:00

The multistage parametric light amplification method comprises passing the pump wave and the signal wave through the signal wave amplifier and separating the idler wave from the propagation trajectory of the pump wave and the signal wave between successive signal wave amplification means. After passing the pump wave and the signal wave through the at least one signal amplification means, the parameters of the pump wave and the signal wave, or the generated idler wave, are modified by at least one modification means.The multistage parametric light amplifier comprises a pump and a signal wave amplification means, and at least one modification means for the pump wave and the signal wave or idler wave.

Inventor: Rimantas Budriūnas

Jurisdiction: EP

Antibodies for photoactive protein manipulation

2023-08-23T08:33:55+03:00

The invention describes a high affinity monoclonal antibody 12B6 that specifically interacts with a photolabile DMNB moiety. This antibody is suitable for recognizing DMNB groups in proteins (and potentially other biomolecules). The interaction of the antibody and the unique DMNB group allows the manipulation of proteins labeled with photolabile groups by immunoprecipitation.

Inventors: Saulius Klimašauskas; Rasa Rakauskaitė; Giedrė Urbanavičiūtė; Rita Lasickienė, Martynas Simanavičius; Aurelija Žvirblienė

Jurisdiction: LT, EP

Utomated tumour-stroma interface zone detection for anti-tumour response assessment by immunogradient indicators

2023-08-23T08:27:11+03:00

We present a new method to automatically sample the tumour/stroma interface zone (IZ) from microscopy image analysis data. It first delineates the tumour edge using a set of explicit rules in grid-subsampled tissue areas; then the IZ of controlled width is sampled and ranked by the distance from the edge to compute TIL density profiles across the IZ. From this data, a set of novel Immunogradient indicators are computed to reflect TIL "gravitation" towards the tumour. We applied the method on CD8 immunohistochemistry images of surgically excised breast and colorectal cancers to predict overall patient survival. In both patient cohorts, we found strong and independent prognostic value of the Immunogradient indicators, outperforming methods currently available. We conclude that data-driven, automated, human operator-independent IZ sampling enables precise spatial immune response measurement in the tumour/host interaction frontline for prediction of disease and therapy outcomes.

Inventors: Arvydas Laurinavičius; Allan Rasmusson; Aušrinė Nestarenkaitė; Dovilė Žilėnaitė; Renaldas Augulis

Jurisdiction: LT, EP, US

Double response ionizing radiation detector and measuring method using the same

2023-08-23T08:03:53+03:00

This invention relates to a method and equipment for the measurements of fluxes and high cumulative doses collected under ionizing irradiations by gamma rays, leptons and hadrons. The proposed sensor comprises structure of homogenous as well as layered, differently doped and semi-insulating wide band-gap semiconductor materials containing both the electrical (ohmic/blocking, Schottky and junction type) and optical fiber probes. The methods for synchronous measurement of optical and electrical signals, the measurement regimes and procedures for processing of signals as well as the measurement data are proposed in order to measure the radiation flux, to estimate the collected fluence (dose) and to track the paths of particle/radiation beams during and after irradiations.

Inventors: Eugenijus Gaubas; Tomas Čeponis; Vidas Kalesinskas; Domas Paipulas; Česlovas Pavasaris

Jurisdiction: LT, EP

Methods for the identification and characterization of double-strand break sites and compositions and uses thereof

2023-08-23T07:50:12+03:00

Methods and compositions are provided for the identification, detection, characterization, and/or utilization of double strand breaks in a target polynucleotide; the identification, detection, characterization, and/or utilization of cutting sites for double-strand-break-inducing agents; and the identification, detection, characterization, and/or utilization of double-strand-break-inducing agents.

Inventors: Stephane Deschamps, Virginijus Šikšnys, Joshua K Young; Mindaugas Zaremba

Jurisdiction: PCT, US, EP, CA

Targeted RNA knockdown and knockout by type III-A Csm complexes

2023-07-04T08:48:19+03:00

Methods and compositions using a CRISPR-Cas Type IIIA resulting in RNA gene knockdown and knockout in an animal.

Inventors: Thomas Fricke; Matthias Bochtler; Gintautas Tamulaitis; Miglė Kazlauskienė; Virginijus Šikšnys

Jurisdiction: US.

Non-invasive approach to early diagnosis and prognosis of acute severe pancreatitis based on heat shock proteins mechanism of action

2023-07-04T08:44:48+03:00

This invention describes a method for early diagnostics of severe pancreatitis using cell membrane damage detection mechanisms. The method involves a non-invasive testing of human urine or other body fluids samples of patients that are suspected to be affected by acute pancreatitis. The invention is based on heat shock protein HSP-70, 90, 60, and 27 role of action in disease progression.

Inventors: Kęstutis Strupas, Aistė Gulla

Jurisdiction: LT, PCT, EP.

3D scanning radar and method for determining altitude of a present object

2023-07-04T08:42:28+03:00

Purpose of the invention is to obtain distance and altitude data of an object position in 3D space by using conventional radar hardware including at least an antenna, a transmitter, a receiver and other devices and equipment required for operation of conventional radars, as well as an additional device for processing and presenting information obtained by the radar.

Inventor: Saulius Rudys

Jurisdiction: LT

N 4-modified cytidine nucleotides and their use

2023-07-04T08:06:13+03:00

The present invention describes W-position modified cytidine nucleotides of formula (I). Provided herein are methods of chemical synthesis of ΛΡ-modified cytidine nucleoside triphosphates and their applications as well as uses of the cytidine analogues for the synthesis of modified nucleic acids. The nucleic acid molecule comprises DNA, RNA or a combination of DNA/RNA. One of many applications of modified cytidine nucleotides described herein is enzyme selection, when an enzyme of interest bears an activity of an esterase, amidase, oxidoreductase, lyase, ligase or other enzymatic activity, formula (I) wherein the substituants are as defined in the appended claims.

Inventors: Rolandas Meškys, Jevgenija Jakubovska; Daiva Tauraitė

Jurisdiction: LT, US, EP

System and method for synthesis of DNA particles and use thereof

2023-07-03T13:44:26+03:00

The present invention relates to system and method for production of DNA particles and use thereof. The DNA particles can be produced by amplification of nucleic acid molecule(s). Alternatively, DNA particles can be prepared by condensing multiple DNA molecules. The DNA condensation into a particle is mainly triggered by pyrophosphate and positively charged cations (e.g. magnesium). DNA particles can be applied for numerous biological applications but not limited to directed evolution, proteomics, drug delivery and imaging. DNA particles can be used to synthesize proteins using in vitro. transcription/translation reaction.

Inventors: Linas Mažutis; Greta Stonytė; Vaidotas Kiseliovas; Rapolas Žilionis; Arvydas Janulaitis; Robertas Galinis; Sabine Studer; Donald Hilvert.

Jurisdiction: EP, US

Selective inhibitors of carbonic anhydrase

2023-07-03T13:18:59+03:00

Invention is related to novel compounds – benzenesulfonamides of general formulas (I) and (II). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit enzymes which participate in disease progression.

Inventors: Daumantas Matulis, Edita Čapkauskaitė, Andrius Zakšauskas; Vaida Morkūnaitė

Jurisdiction: US, EP

Easily deployable phased antenna for a spacecraft and system of such antennas

2023-07-03T13:05:52+03:00

The proposed antenna can be made from strips of a shape-memory alloy or other resilient material acting as a spring with attached branches that constitute individual monopole antennas. In the folded state, the antenna looks like a strip roll and can be placed on a satellite. When in orbit, the antenna automatically unfolds after the roll retention mechanism is released and orderly unfolds unrolling from a support frame or otherwise extends. The proposed design of monopole branches utilizes conductors of minimum length and achieves maximum directivity. Each monopole branch is connected to the signal receiver/transmitter by means of signal conduit elements. A system may include at least two such unfolding antennas thus achieving even greater operational effectiveness in regard to signal steerability, interference suppression and reduced moment of the satellite inertia. To prevent chaotic deployment of the antenna, additional measures are used that prevent unwinding of inner layers of the roll before the outer layer is extended.

Inventors: Saulius Rudys, Jūras Banys

Jurisdiction: LT, US, EP

Method and instrumentation for measurement of large fluences and doses of high energy irradiations

2023-07-03T13:03:23+03:00

This invention relates to method and equipment for the measurement of large doses of irradiation, and is addressed to simultaneous detection and dosimetry of gamma rays and high@energy hadrons, which is implemented by exposing of the tandem dosimeters to unknown radiation, by receiving data at the first reader electronic paramagnetic resonance spectrometer, from at least one dosimeter, that is set to detect gamma rays, and additionally, at the second reader carrier recombination lifetime meter, from at least one dosimeter, that is set to detect hadron irradiation, using contactless means of microwave probed photoconductivity transients in monocrystalline silicon coated of properly passivated surfaces under excitation of a pulsed lR laser, linkage of the obtained data in both, alanine and silicon sensors, arranged into single tandem dosimeter, and evaluation of the dose, the spatial dose distribution of gamma rays and hadron irradiation using the relevant models and analysis software.

Inventors: Eugenijus Gaubas, Tomas Čeponis, Vidas Kalesinskas, Vidmantas Juozas Vaitkus

Jurisdiction: LT, EP

Programmable RNA shredding by the type III-A CRISPR-Cas system of Streptococcus thermophilus (I)

2023-07-03T12:59:55+03:00

A Type III-A CRISPR-Cas (St Csm) complex of Streptococcus thermophilus comprising crRNA, Csm4, and Csm3 and use for cleavage of RNA bearing a nucleotide sequence complementary to the crRNA, in vitro or in vivo. Methods for site-specific cleavage/shredding of a target RNA molecule using an RNA-guided RNA endonuclease comprising a minimal complex of crRNA, Csm4, and Csm3, and methods of RNA knock-down and RNA knock-out are disclosed. 999211.

Jurisdiction: EP, US

System and method for producing target biological substances

2023-07-03T12:30:16+03:00

A biomimetic microfluidic system and a method are provided for producing target biological substances. The system comprises a first channel extending from a first input to a first output along a longitudinal dimension. The first channel is configured to receive at least one first biological composition at a first channel flow rate. The at least one first biological composition comprises a biological source material capable of producing target biological substances. The system further comprises a second channel substantially parallel to the first channel, extending from a second input to a second output along the longitudinal dimension. The second channel is configured to selectively receive at least one second biological composition at a second channel flow rate. The system further comprises a separation barrier between the first channel and the second channel. The separation barrier has a plurality of microchannels forming a fluid communication path between the first and second channels.

Inventors: Joseph Italiano; Linas Mažutis; Jonathan Thon; David A. Weitz

Jurisdiction: AU, CN, EP, JP, US

System and method for a biomimetic fluid processing (II)

2023-07-03T11:59:45+03:00

A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.

Jurisdiction: US, AU, CN, EP, JP, CA, HK, JP, CA

Programmable RNA shredding by the type III-A CRISPR-Cas system of streptococcus thermophilus (II)

2023-07-03T11:50:33+03:00

Jurisdiction: US, EP.

Analysis of methylation sites

2023-07-03T11:28:24+03:00

The present invention provides a method for labeling unmethylated CpG dinucleotides within a DNA fragment, and use of the method in profiling of genomic DNA methylation. The present invention further provides modified DNA ethyltransferase enzymes and compounds which are capable of being used by the enzymes as cofactors for use in the labeling method.

Inventors: Saulius Klimašauskas, Edita Kriukienė, Giedrė Urbanavičiūtė, Artūras Petronis, Tarang Khare, Sun Chong Wang

Jurisdiction: EP, US

5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone and the intermediates for production thereof

2023-07-03T11:14:14+03:00

Invention is related to novel compounds -5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles with general formula (I). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit Hsp90 chaperone which participate in cancer progression. This invention is also related to new intermediate compounds which are used for the synthesis of thiadiazoles of general formula (I).

Inventors: Daumantas Matulis, Inga Cikotienė, Egidijus Kazlauskas, Jurgita Matulienė

Jurisdiction: US

System and method for a biomimetic fluid processing (I)

2023-06-22T10:59:16+03:00

Inventors: Joseph Italiano, Linas Mažutis, Jonathan Thon, David A. Weitz

Jurisdiction: EP, CN