Faculty of Medicine

Sukurta: 29 June 2019

21 M.K. 膶iurlionio, LT-03101 Vilnius
Tel. 239 8700,
E-mail:

Dean 鈥� Prof. Habil. Dr. Algirdas Utkus

STAFF

517 teachers (incl. 337 holding research degree), 84 research fellows (incl. 61 holding research degree), 151 doctoral students.

DEPARTMENTS OF THE FACULTY

INSTITUTE OF BIOMEDICAL SCIENCES:

Department of Anatomy, Histology and Anthropology
Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine
Department of Pathology, Forensic Medicine and Pharmacology
Department of Radiology, Nuclear Medicine and Physics of Medicine
Department of Human and Medical Genetics

INSTITUTE OF CLINICAL MEDICINE:

Clinic of Obstetrics and Gynecology
Clinic of Anaesthesiology and Reanimatology
Clinic of Ear, Nose, Throat and Eyes Diseases
Clinic of Gastroenterology, Nephrourology and Surgery
Clinic of Infectious Diseases and Dermatovenereology
Clinic of Chest Diseases, Immunology and Allergology
Clinic of Neurology and Neurosurgery
Clinic of Psychiatry
Clinic of Rheumatology, Orthopaedic and Traumatology and Reconstructive Surgery
Clinic of Cardiovascular Diseases
Clinic of Children鈥檚 Diseases
Clinic of Internal Medicine, Family Practice and Oncology
Clinics of Emergency Medicine

INSTITUTE OF ODONTOLOGY

INSTITUTE OF HEALTH SCIENCES:

Department of Rehabilitation, Physical and Sports Medicine
Department of Nursing
Department of Public Health

RESEARCH AREAS

Human Genome Diversity, Its Origin and Phenotypic Realization
Human and Public Health, Quality of Life and Environment
Etiopathogenesis, Diagnostics, Treatment of Diseases: Fundamental and Clinical Research, Innovative Technologies

DOCTORAL DISSERTATIONS MAINTAINED IN 2018

I. Slivovskaja. The effectiveness of individual aerobic training in subjects with metabolic syndrome.
沤. Juodeikis. Adjustable gastric banding: a randomized clinical trial comparing 5-year results of two different bands.
A. Bei拧a. Significance of BRAF V600E mutation and cytomorphological features for the optimization of papillary thyroid cancer diagnostics.
A. Strumila. Evaluation of treatment effectiveness and prognosis of infantile hemangioma by infrared thermography.
E. Nedzinskien臈. Peculiarities of ultrastructure of tooth root canals treated with resorcinol formaldehyde resin, evaluation of influence of endodontic retreatment procedures and resistance to fracture. Study in vitro.
E. Vinda拧i奴t臈-Narbut臈. Factors associated with removal of the cement excess in implant-supported restorations.
A. Rimkevi膷ius. The study of patients with oral lichen planus: clinical indices, risk factors and quality of life.
H. M. A. Aliahmed. Comparison of results of aortic valve replacement through median sternotomy and ministernotomy.
J. Ber奴k拧tis. Evaluation of the efficacy of catheter-based renal sympathetic denervation for treating resistant arterial hypertension.
V. Paliulyt臈. Ultrasound evaluation of postpartum uterus morphological parameters in their relationship with maternal and newborn health indicators.
G. Ra膷kauskas. Sub threshold high frequency electrical field stimulation effect for angiogenesis and vegf expression in cardiomyocytes and heart tissue. Remodelling in the heart: impact of mechanical stretch, threshold and sub-threshold electrical stimulation on cultivated cardiomyocytes and sympathetic neurons.
E. Lycholip. Telemonitoring technologies for heart failure patients: opinions of professionals, patient-reported outcomes and measurements of lung impedance.
A. Lau膷yt臈-Cibulskien臈. Arterial stiffness and other biomarkers as vascular remodelling and cardiovascular risk predictors in patients on renal replacement therapy.
A. Zorinas. Incidence and risk factors of the mitral paravalvular leak and comparison of the treatment modalities.
A. Am拧iejien臈. Multivariate analysis of Lithuanian infertile women鈥檚 biological factors.
D. Palionis. The importance and clinical application of magnetic resonance tomography contrast unenhanced sequences in diagnostics of aorta pathology.
J. Besusparis. The assessment of the breast cancer proliferation rate and its intratumor heterogeneity using digital immunohistochemistry methods.
B. Burnyt臈. Evaluation of genetic and phenotype heterogeneity in hereditary neuropathies.
A. Urnikyt臈. Evaluation of genetic structure and evolutionary forces of the Lithuanian population according to the high-density genotyping data: past and the future.
S. Kutkien臈. Assessment and modification of dyslipidemias: effect on etiopathogenesis and prevention of cardiovascular diseases and relationship with other atherosclerotic risk factors.
B. Buckus. Adipose tissue composition and distribution differences in predicting metabolic disorders in obese patients.
A. Mulevi膷ien臈. The relationship between nutritional anemia and changes of health indicators and fecal microbiota in infancy and early childhood.
R. Strupait臈. The evaluation of inherited retinal dystrophies clinical and genetic characteristics.

MAIN CONFERENCES ORGANIZED IN 2018

Institute of Biomedical Sciences:
21st European Congress of Physical & Rehabilitation Medicine;
14th Baltic Congress of Laboratory Medicine;
4th International Conference of Evolution Medicine;
International scientific practical conferences Dysmorphology Summer 2018; Innovative Pathology.

Institute of Clinical Medicine:
International conferences: 9th Baltic Congress of Neurology (BALCONE 2018); Dermatovenereology update 2018;
International conference and workshops Hysteroscopy and actual problems of infertility;
International practical conference Baltic Sea Summer School of Epilepsy;
6th international meeting on Acute Cardiac Care and Emergency Medicine;
2nd Baltic and 3rd Lithuanian Pulmonary Hypertension Conference;
1st Northern鈥揈astern Postgraduate course Arterial Stiffness and Vascular Aging;
9th international conference Innovations in the Management of Rare Diseases;
Small Group 鈥� Endless Space. Personal therapy in group analytic training;
ECPCP (European Confederation of Primary Care Paediatricians) annual meeting.

Institute of Odontology:
International conferences Tipicality in periodontology; Endodontology 2018;
23rd international conference (R)Evolution in prosthodontics;
International annual meeting of Lithuanian Society of Prosthodontics;
1st international conference for students and residents.

Institute of Health Sciences:
21st European Congress of Physical & Rehabilitation Medicine;
9th Congress of Baltic Association of Surgeons, section Surgical Nursing;
International conference Nursing Education and Research in Baltic Countries.

BEST PRESENTATIONS MADE AT CONFERENCES ABROAD

Institute of Biomedical Sciences:

Tre膷iokien臈, Indr臈; Gulbinovic, Jolanta; Raga啪inskien臈, Ona; Taxis, Katja. Patients鈥� knowledge and beliefs of high blood pressure: questionnaire for health care professionals. FIP 2018: World congress of pharmacy and pharmaceutical sciences: 78th annual congress of FIP, 2鈥�6 September, 2018, Glasgow, Scotland.

Kliokyte, R奴ta; Vajauskas, Donatas; Jankauskien臈, Augustina. 1DMSA scan abnormalities in infants with sterile high grade vesicoureteral reflux. C-1156. European congress of radiology, 28 Feb鈥�04 Mar 2018, Vienna, Austria.

Tutkus, Vytautas; 艩ilov臈, Simona; Tutkuvien臈, Janina. Thickness of hamstring tendons for anterior cruciate ligament surgery in relation to body size. & Tutkuvien臈, Janina; Tutkus, Vytautas. Gender differences in body image of young Lithuanian adults in relatios to biopsychosocial factors. 21 Congress of the European Anthropological Association, 22鈥�25 August, 2018, Odense, Denamrk.

Vitkus, Dalius; Beinoras, Evaldas Avis; Pelanti, Jonna. Integrated External Quality Assessment Schemes: First Experience. 5th Joint EFLM-UEMS Congress, 10鈥�13 October, 2018, Antalya, Turkey.

Besusparis, Justinas. Automated Ki67 鈥淧areto Hotspot鈥� is an independent prognostic factor in breast cancer patients. & Laurinavicius, Arvydas. Getting pathology pixels to work. 14^th European Congress on Digital Pathology and 5th Nordic Symposium on Digital Pathology, May 29鈥揓une 1, 2018 Helsinki, Finland.

Vitkus, Dalius; Pelanti, Jonna. EQA scheme with metrological traceability: what can we learn from continuous performance evaluation of participating laboratories? XXXVI Nordic Congress in Clinical Chemistry 鈥淚nformation Beyond Numbers鈥�, June 12鈥�15, 2018, Helsinki, Finland.

Kar膷iauskait臈, Dovil臈; Burokien臈, Neringa; Matuzevi膷ien臈, Reda; Ma啪eikien臈, Asta; Ku膷inskien臈, Zita Au拧rel臈. Impact of chronic stress on atherosclerosis process. & Bikul膷ien臈, Inga; Golubevait臈, Orinta; Kar膷iauskait臈, Dovil臈; Hendrixson, Vaiva; Kaminskas Arvydas; Ku膷inskien臈, Zita Au拧rel臈. The relationship between fatty acid composition of platelet membrane, blood serum malondialdehyde and body mass index in healthy men. 7th Baltic Atherosclerosis Congress, April 6鈥�7, 2018, Tallinn, Estonia.

Suchomlinov, Andrej; Tutkuvien臈, Janina. Changes in growth of Lithuanian children from 1990. Countries in Socioeconomic Transition: Evidences from Auxology and Allied Disciplines: international symposium, November 21鈥�24, 2018, Kolkata, India.

Zentelyt臈, Aist臈; Treigyt臈, Gra啪ina; Baronait臈, Sandra; Krasovskaja, Natalija; Savickien臈, J奴rat臈; Borutinskait臈, Veronika Viktorija; Navakauskien臈, R奴ta. Epigenetics of adipogenic and osteogenic differentiation of MSCs isolated from amniotic fluid of healthy and fetus-affected pregnancies. Cambridge International Stem Cell Symposium, September 19鈥�21, 2018, Cambridge, England. <>

Matuzeviciene, Reda; Janiulioniene, Ausra; Radzevicius, Mantas; Janeliuniene, Migle. T follicular helper cells in health and disease. European Society for Clinical Cell Analysis (ESCCA) 2018, September 12鈥�15, 2018, Valencia, Spain.

Institute of Clinical Medicine:

Vinikovas, Art奴ras; 沤eimait臈, Rasa; Navardauskait臈, Kamil臈 Evelina; Verikas, Dovydas; Kablu膷ko, Denis; Sta拧aitis, K臋stutis; Mebazaa, Alexandre;Kavoli奴nien臈, Au拧ra; 膶elutkien臈, Jelena. Ischemic origin of heart failure is associated with worse prognosis in 3 and 12 months after acute episode. & Vinikovas, Art奴ras; Zeimaite, Rasa; Navardauskaite, Kamile Evelina; Ziubryte, Greta; Tribusauskaite, Sarune; Vaiciuliene, Dovile; Kablucko, Denis; Stasaitis, Kestutis; Mebazaa, Alexandre; Kavoliuniene, Au拧ra; Celutkiene, Jelena. Abnormal potassium level predicts long-term outcomes in patients with acute dyspnea. The Heart Failure 2018 and the World Congress on Acute Heart Failure, May 26鈥�29, 2018, Vienna, Austria.

Gedvilaite, Vaida; Danila, Edvardas; Cicenas, Saulius; Smailyte, Giedr臈. P1.15-09 Trends in Lung Cancer Survival in Lithuania. 19th World Conference on Lung Cancer 2018, September 23鈥�26, Toronto, Canada.

Kuliese, Monika; Jancoriene, Ligita; Grimalauskaite, Rita; Zablockiene, Birute; Damuleviciene, Gyte; Lesauskaite, Vita; Velyvyte, Daiva; Krupeckaite, Kotryna; Bagdonas, Alfredas; Ambrozaitis, Arvydas; Mickiene, Aukse; Gefenaite, Giedre. Seasonal influenza vaccine effectiveness among hospitalized elderly patients against laboratory-confirmed influenza in 2015鈥�2017 in Lithuania. 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018), April 21鈥�24, 2018, Madrid, Spain.

Mald啪i奴t臈, Diana; Bumbulien臈, 沤ana. Ovarian adult granulosa cell tumor in one of identical adolescence twin with uterus didelphys and kidney agenesis. 26th European Congress of the European Board & College of Obstetrics and Gynaecology, March 8鈥�10, 2018, Paris, France.

Kubilius, Darius; Brad奴nait臈, Rasa; Zacharevskij, Ernest; Brimas, Gintautas. The significant outcome of controlled intervention of well-established burns treatment plan: reduced hospital stay and rate of complications. 8th Central European Burn Congress, May 31鈥� June 1, 2018, Bratislava, Slovakia.

Burokiene, Sigita; Pilkien臈 Aist臈. Health literacy study of parents in pediatric emergency department. EAPS 2018, 7th Congress of the European Academy of Paediatric Societies. October 30鈥揘ovember 3, 2018, Paris, France.

Dlugauskas, Edgaras; Lengvenyt臈, Aist臈; Strumila, Robertas; Utkus, Algirdas. Lithuanian CYP2D6 polymorphism analysis (pilot study). Psychiatry 鈥� Shaping the Future : 32nd Nordic Congress of Psychiatry, June 13鈥�16, 2018, Reykjavik, Iceland.

Hamarat, Yasin; Deimantavicius, Mantas; Zakelis, Rolandas; Bartusis, Laimonas; Preik拧aitis, Aidanas; Ragauskas, Arminas. A pilot study of non-invasive intracranial pressure monitoring. Bioelectrics 2018: 15th International Bioelectrics Symposium, September 23鈥�26, 2018, Prague, Czech Republic.

艩al膷i奴t臈, Erika; Liu膷vaikyt臈, Julita; Klima拧auskas, Andrius; K臈k拧tas, Gintautas; 艩ipylait臈, J奴rat臈. Energy expenditure measured by indirect calorimetry and provision of energy and protein for patients with acute severe pancreatitis & 艩al膷i奴t臈, Erika; Liu膷vaikyt臈, Julita; Klima拧auskas, Andrius; K臈k拧tas, Gintautas; 艩ipylait臈, J奴rat臈. Energy requirements in patients with acute severe pancreatitis: comparison between indirect calorimetry and validated equations. Critical Care: 38th International Symposium on Intensive Care and Emergency Medicine, March 20鈥�23, 2018, Brussels, Belgium.

Samalavicius, Narimantas Evaldas. Local rectal cancer treatment. International Congress to the 25th Anniversary of the Central and Eastern European Club of Coloproctology, April 27鈥�28, 2018, Brno, Check Republic.

Institute of Odontology:

Vasciunaite-Tyliene, Julija; Brukiene, Vilma; Rizgelyte Deligoz, Jolita; Tanboga, Ilknur. Oral health status of children with Cerebral Palsy in Istanbul (Turkey) and Vilnius (Lithuania). 24th International Association for Disability and Oral Health Congress, August 31鈥揝eptember 2, 2018, Dubai, JAE.
Drukteinis, Saulius; Buzyt臈, Ieva; Pe膷iulien臈, Vytaut臈. Micro-CT evaluation of dentinal microcrack formation after using rotary, hybrid and reciprocating NiTi instruments. The 11th IFEA World Endodontic Congress, October 4鈥�7, 2018, Seoul, Korea.

Drukteinis, Saulius. Flowable bioceramic materials in endodontics. Clinical application and 3D reality. The 11th IFEA World Endodontic Congress, October 4鈥�7, 2018, Seoul, Korea.

Linkevicius, Tomas. Tissue thickness and platform switching. Science and practice. Lecture in Global DentalXP Symposium, February 6鈥�9, 2018. Miami, USA.

Linkevicius, Tomas. Zero bone loss concepts. Lecture in Australian Osseointegration Society, October 15, 2018, Brisbane, Australia.

Institute of Health Sciences:

Alekna, Vidmantas; Cernovas, Andrejus; Stukas, Rimantas; Mastaviciute, Asta; Tamulaitiene Marija. The associations between handgrip strength, BMD and fracture probability in elderly women. Poster presentation. & Cernovas, Andrejus; Stukas, Rimantas; Grigaite, Jurate; Tamulaitiene, Marija; Surkiene, Gene; Alekna, Vidmantas. The associations between quality of life and psychoemotional state in elderly women. Poster presentation. & Cernovas, Andrejus; Fabijonavicius, Mantas; Sadauskaite, Grazina; Tamulaitiene, Marija; Alekna Vidmantas; Stukas Rimantas. The relationships between satisfaction and emotional state in elderly women. Poster presentation. World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases. April 19鈥�22, 2018, Krakow, Poland.

Juocevi膷ius, Alvydas; Gulbinait臈, Laura; Adomavi膷ien臈, Au拧ra; Narutyt臈, Evelina; Dadelien臈, R奴ta. Effectivness of rehabilitation for patients with spinal cord injury in C4 鈥� C8 segments based on the international classification of functioning, disability and health. & Mickut臈, Gabriel臈; Bunevi膷i奴t臈, Ramun臈; Luk拧ys, Donatas; Ku膷inskas, Martynas; Kaladyt臈 Lokominien臈, R奴ta; Jatu啪is, Dalius; Juocevi膷ius, Alvydas; Gri拧kevi膷ius, Julius. The influence of Lindy Hop dance therapy on motor function and quality of life for patients with Parkinson鈥檚 disease. 21st European Congress of Physical and Rehabilitation Medicine, May 1鈥�6, 2018, Vilnius, Lithuania.

Apsega, Andrius; Mastaviciute, Asta; Tamulaitiene, Marija; Alekna, Vidmantas. Relations between frailty, multimorbidity and disability in specific activities in daily living in community-dwelling women: a cross-sectional study. 14th International Congress of the European Geriatric Medicine Society. 10鈥�12 October 2018, Berlin, Germany.

Dadelien臈, R奴ta; Nekrio拧ius, Ri膷ardas; Mila拧ius, Kazys. Peculiarities of muscle oxygenation in world-class kayakers. 23rd Annual Congress of the European College of Sport Science, July 4鈥�7, 2018, Dublin, Ireland. <>.

Skruibis, Paulius; Germanavi膷ius, Ar奴nas. Inverse relationship between suicide rates and undetermined, ill-defined and unknown causes of death in Lithuania, but not in Latvia and Estonia. 17th European Symposium on Suicide and Suicidal Behaviour, September 5鈥�8, 2018, Ghent, Belgium.

Raistenskis, Juozas; Aukstikalnis Tomas. Vibroacoustic therapy as an option to treat adolescent鈥檚 low back pain. International multidisciplinary conference Rehabilitation Yesterday - Today - Tommorow. October 19鈥�20, 2018, Olsztyn, Poland.

Jokubauskien臈, Marija. Mental health during the life course: use of registry data. & Donatas Austys. Smoking and distribution of adipose tissue. & Valerij Dobrovolskij. The factors determining students鈥� physical activeness. 11th European Public Health Conference. Winds of Change: Towards New Ways of Improving Public Health in Europe, November 28鈥揇ecember 1, 2018, Liubliana, Slovenia.

Gedrim臈, Lina; Fatkulina, Natalja. Patients鈥� information needs about surgery. Lietuvos chirurgija: 9-asis Baltijos 拧ali懦 chirurg懦 asociacijos kongresas (Lithuanian Surgery: 9th Congress of Baltic Association of Surgeons), May 10鈥�12, 2018, Klaip臈da, Lithuania.

沤agminas, K臋stutis. 沤IV, HBV, HCV paplitimas ir rizika Lietuvoje / HIV, HBV, HCV Prevalence and Risk in Lithuania. 5-oji tarptautin臈 mokslin臈s-praktin臈 konferencija 鈥溑爄uolaikin臈 kraujo komponent懦 transfuzija 鈥� nuo donoro iki recipiento鈥�(Modern Blood Component Transfusion 鈥� from Donor to Recipient). October 10, 2018, Vilnius, Lithuania.

INSTITUTE OF BIOMEDICAL SCIENCES

DEPARTMENT OF ANATOMY, HISTOLOGY AND ANTHROPOLOGY

21/27 M. K. 膶iurlionio, LT-03101 Vilnius
Tel. 239 87 06
E-mail:

Head 鈥� Prof. Dr. Janina Tutkuvien臈

STAFF

Professors: Dr. R. Jankauskas, Dr. R. 艩imk奴nait臈-Rizgelien臈, Dr. J. Tutkuvien臈, Dr. V. 沤algevi膷ien臈.
Associate professors: Dr. A. Barkus, Dr. R. 膶epulien臈, Dr. E. M. Jakimavi膷ien臈, Dr. 沤. Miliauskien臈, Dr. L. Nedzinskien臈, Dr. A. Suchomlinov, Dr. V. Tutkus (part-time).
Assistants: D. Bandzevi膷ien臈 (part-time), K. Kuolien臈 (part-time), dr. M. Leonavi膷i奴t臈-Klimantavi膷ien臈 (part-time), V. Luko拧aitis (part-time), R. Mackevi膷ien臈, R. Mork奴nien臈.
Lecturers: A. Audickait臈 (part-time), dr. V. Bartu拧kien臈 (part-time), L. Bra膷kut臈 (part-time), R. Jacevi膷i奴t臈 (part-time), J. Janavi膷ius (part-time), J. Jara拧奴nas (part-time), M. Minsevi膷ius (part-time), K. Popov (part-time).
Research fellows: senior researcher Dr. D. Piombino-Mascali, junior researcher S. 艩ilov臈.
Doctoral students: G. Laurinavi膷i奴t臈, K. Kuolien臈, V. Luko拧aitis, R. Mork奴nien臈, A. Vaitiekus.
Students鈥� scientific group of Human biology and evolutionary medicine: scientific leader 鈥� Prof. J. Tutkuvien臈; coordinator 鈥� student J. Petkevi膷i奴t臈; in total 鈥� 37 members of students.

RESEARCH INTERESTS

Human Genome Diversity, Its Origin and Phenotypic Realization

Skeletal and dental health indicators in Lithuanian paleopopulations and potential ecological, social, demographic factors of their variability

The peculiarities and factors of prenatal development, growth programming and postnatal development in both humans and experimental animals (chicken embryos, rats)

The physical status of contemporary inhabitants, the internal and external factors of phenotypic variation, the relationship between indices of physical and general health status, the analysis of secular trend and prognosis of future tendencies

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Phenotype Variety of Inhabitants of Lithuania, Its Prenatal and Postnatal Factors, Secular changes, Relations with General Health Status. Prof. J. Tutkuvien臈, Prof. R. Jankauskas. 2014鈥�2018.

Bioarcheological Investigations.

Relations between morphometric indices as proxy for health status, childhood life conditions and demographic indicators were examined. Systemic analysis of traumatism in medieval populations was performed. As a summary of these studies, two PhD dissertations were defended. Paleopathological and paleoradiological investigations of mummified human remains were continued. Analysis of growth and health of children in postmedieval Lithuania was performed. Data of porotic hyperostosis and antemortem tooth loss from selected 16鈥�17th c. populations, and dental status of 19th c. inhabitants of Panev臈啪ys were summarised.

Main publications:

Jatautis, 艩., Suchomlinov, A., Jankauskas, R. 2018. An association between adult lifespan and stature in preindustrial Lithuanian populations: analysis of skeletons. HOMO: Journal of Comparative Human Biology, vol. 69, no 4, p. 167鈥�175, doi: 10.1016/j.jchb.2018.07.001.

Kozakait臈, J., Piombino Mascali, D., Miliauskien臈, 沤., Gir膷ius, R., Dementavi膷ien臈, J., Jankauskas, R. 2018. A rare case of child abuse from early modern Lithuania. International Journal of Paleopathology, vol. 22, p. 189鈥�197, doi: 10.1016/j.ijpp.2018.06.008

Panzer, S., Augat, P., Zink, A.R., Piombino-Mascali, D. 2018. CT checklist and scoring system for the assessment of soft tissue preservation in human mummies: application to catacomb mummies from Palermo, Sicily. International Journal of Paleopathology, vol. 20, p. 50鈥�59, doi: 10.1016/j.ijpp.2018.01.003

Experimental (growth programming) Investigations.

Further collecting and analysis of data from the experimental study on the influence of maternal nutrition prior to pregnancy and during pregnancy was carried out: the behavioural video record data of two rat offspring generations coded with Noldus software were analysed. The histomorphological profile of the rat offspring eyes was determined with an analysis of photoreceptors, M眉ller cells, ganglion cells layer and retinal microglia. The results were presented at international conference. Further analysis of data from the experimental study on the influence of the drinking water was carried out: influence of ionized water on the embryo development and the effects of boron and fluorine on the rat embryo mass, skeleton formation and teeth structure were analyzed, the results were presented at international conference and the scientific article was prepared.

Investigations of physical status of contemporary inhabitants.

Using the data from the period 1995鈥�2015, the analysis of newborns whose mothers were addicted to alcohol and drugs during pregnancy was performed; materials on birth anomalies during the 1997鈥�2013, also materials on newborns head circumference comparison with INTERGROWTH study were prepared for publication. The longitudinal growth data were collected for 120 preterm newborns. The study on physical status (according to wide programme) of 19鈥�20 years old Lithuanians was continued (50 medical students were investigated). The comparative study on menarcheal age in relation to social, economic, food consumption and geographic factors in more than 50 countries was fulfilled. The results on changes of body image (BI) during the pregnancy have been published. The analysis on face recognition in preschool children was finalised. The results of study on breast changes in females during the pregnancy were submitted for publication. The study on physical status, health, body image and psychological status of incarcerated women was continued. The analysis on handedness of 200 individuals was finished. The study on the relationship between the alignment of joints, the lower limb function and physical status of young adults was continued: all length X-rays of both lower extremities were performed (N=30) and compared with the results of physical examination. The patellar cartilage status (chondromalacia) was analysed in the knees of more than 2000 individuals. The preparation for the study on anatomical variants of cerebral arteries in relation to cerebral vascular pathologies was finished.

Main publication:

Tutkuvien臈, J., Ju拧kait臈, A., Katinait臈, J., 艩ilov臈, S., Dr膮sutis, J., Sargautyt臈, R., Rama拧auskait臈, D., Dr膮sutien臈, G. 2018. Body image issues in Lithuanianfemales before and during pregnancy. Anthropologischer Anzeiger, vol. 75, no. 1, p. 9鈥�17, doi: 10.1127/anthranz/2018/0779.

Tutkus, V., Tutkus, J., Jablonskiene, V., Abaravicius, J.A., Silove, S., Tutkuviene, J. 2018. Tibial part of anterior cruciate ligament: a host for silent foreign body in the knee. Chinese Medical Journal, vol. 131, no 15, p. 1884鈥�1886, doi: 10.4103/0366-6999.237410.

Koziel, S., Scheffler, C., Tutkuviene, J., Jakimaviciene, E. M., Mumm, R., Barbieri, D., Godina, E., El-Shabrawi, M., Elhusseini, M., Musalek, M., et al. 2018. Growth and social environment. Pediatric Endocrinology Reviews Per, vol. 15, iss. 4, p. 319鈥�329, doi: 10.17458/per.vol15.2018.ksh.mr.GrowthSocialEnvironment.

National Research Projects

Granted by Research Council of Lithuania. Osteological Material as the Source for Lithuanistic Research: Knowledge, Systemization and Access. (No. S-LIP-18-50 / LSS-150000-1175). Assoc. Prof. 沤. Miliauskien臈 (leading scientist), Dr. J. Kozakait臈 (researcher) 2018鈥�2020.

Preliminary account of human osteological collection was performed. All cremated remains in the collection were reanalized and reinventorized. Trial version of digital osteological data base was created.

Granted by National Museum of Lithuania, and the Genocide and Resistance Research Centre of Lithuania: Anthropological Investigation of Skeletal Remains of the January Uprising (1863鈥�1864) at the Gediminas Hill in Vilnius. Prof. R. Jankauskas (leading scientist); Assoc. Prof. 沤. Miliauskien臈 (researcher), Dr. J. Kozakait臈 (researcher) 2017鈥�2018.

Skeletal remains of 20 participants of The January Uprising (1863鈥�1864) were discovered on the Gediminas Hill. Identity of several individuals was confirmed by anthropological, forensic and genetic analysis, archeological findings. Investigation is proceeded.

Granted by The Genocide and Resistance Research Centre of Lithuania: Anthropological Investigations of Orphans鈥� Cemetery of the 19th c. in Vilnius. Prof. R. Jankauskas (leading scientist); Assoc. Prof. 沤. Miliauskien臈 (researcher), Dr. J. Kozakait臈 (researcher) 2017鈥�2018.

Historical, archaeological and anthropological investigations of Orphan鈥檚 Cemetery of the 19th c. in Vilnius lead to the discovery of 16 remains of victims of Soviet repressions (1956鈥�1969). Remains of one of the prominent leaders of the Lithuanian partisans鈥� movement Adolfas Ramanauskas-Vanagas (1918鈥�1957) and some other individuals were identified by complex anthropological and forensic analysis. Investigation is continued.

International Research Projects

International projected (44 countries) coordinated by Prof. Viren Swami (Anglia Ruskin University and Perdana University). The Breast Size Satisfaction Survey (BSSS). Prof. J. Tutkuvien臈 (leading scientists of Lithuanian partner). 2017-2019.

In total 135 females from Lithuania (aged 18鈥�38 years) were investigated with respect to their actual body size, body image and breast satisfaction, the statistical analysis of interrelationship between real body dimensions, self-perception and attractiveness soring was performed on Lithuanian sample.

HORIZON-2020 project coordinated by CEITEC Masaryk University in Brno, Czech Republic: EU-13 countries 鈥淎lliance for Life: Closing Research and Innovation Divide in the European Union鈥�. Prof. J. Tutkuvien臈 (Strategy Board member from Lithuanian partner 鈥� 91桃色, Faculty of Medicine). 2017-2019.

Three meetings were organized; the materials with regard to organisation and management of research activities, research evaluation criterions and research infrastructure were cumulated from 13 EU countries (all partners of the project). Declarations with respect to research policy development in EU, closer collaboration, sharing experience, supporting creative and most novel research for an overall increase in scientific developments in Central and Eastern Europe were conducted. It was concluded that one of the main weakness is underdevelopment of career system in Central and Eastern Europe for investigators, and it is necessary to examine human resources policies and practices at the partner institutions of the project.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Institute of Anthropology, University of Vienna (Austria)
Max-Planck-Institute, Starnberg-Seewiesen (Germany)
Institute of Evolutionary Medicine, University of Z眉rich (Switzerland)
Institute for Anthropological Research, Zagreb (Croatia)
Loughborough University, Leicestershire (UK)
The Institute for Mummy Studies, Bolzano (Italy)
Institute of Forensic Medicine, Heinrich-Heine University of D眉sseldorf (Germany)
Department of Anatomy, University of G枚ttingen (Germany)
University of Central Florida, Orlando, Florida (USA)
Medical University of Lodz (Poland)
University of Torun (Poland)
Institute of Anatomy and Anthropology, Riga Stradins University (Latvia)
Cranfield University (UK)
University of Tartu (Estonia)
McMaster University (Canada)
University of Catania (Italy)
State Forensic Medicine Service (Lithuania)

OTHER SCIENTIFIC ACTIVITIES

Prof. J. Tutkuvien臈 鈥�

member of the Council of the Faculty of Medicine;
chairperson of the Scientific Committee of the Faculty of Medicine;
chairperson of the Doctoral Committee of the Faculty of Medicine;
member of the European Anthropological Association;
member of the Council of the European Anthropological Association;
member of the Commission for Human Ecology of International Union of Anthropological and Ethnological Sciences (IUAES);
member of the International Association of Human Biologists;
member of the Society for Studies of Human Biology;
member of the International Auxollogical Society;
member of the Lithuanian Morphological Society;
member of the Lithuanian Society of Obstetricians and Gynaecologists (Section of Gynaecology of Children and Adolescents);
editorial board member of the Journal of Human Ecology;
editorial board member of the journal Acta Medica Lituanica;
editorial board member of the journal Visuomenes Sveikata (Public health);
editorial board member of the journal Anthropologischer Anzeiger;
editorial board member of the journal 袙械褋褌薪懈泻袦芯褋泻芯胁褋泻芯谐芯褍薪懈胁械褉褋懈褌械褌邪. 小械褉懈褟 23. 袗薪褌褉芯锌芯谢芯谐懈褟.

Prof. R. Jankauskas 鈥�

editorial boards member of the journals: Papers on Anthropology (Tartu University, Estonia); Anthropologischer Anzeiger; Lietuvos archeologija; Archaeologia Baltica;
member of the Board of the European Anthropological Association;
member of the Scientific Council of the Lithuanian Institute of History;
member of the Scientific Council of the Nature Research Center;
member of Lithuanian Academy of Sciences ();
member of Paleopathology Association.

Prof. R. 艩imk奴nait臈-Rizgelien臈 鈥�

member of the European Anthropological Association;
board member of the Lithuanian Morphological Society.

Prof. V. 沤algevi膷ien臈 鈥�

vice-chairperson of the Commision of Appeal at the Faculty of Medicine;
member of the Lithuanian Morphological Society;
member of Baltic Laboratory Animal Association (Balt-LASA).

Senior Research Fellow D. Piombino-Mascali 鈥�

member of Paleopathology Association;
honorary membership at American Society of Embalmers.

Assoc. Prof. A. Barkus 鈥�

member of the Lithuanian Morphological Society;
member of the European Anthropological Association;
member of the Lithuanian Society of Archaeology.

Assoc. Prof. R. 膶epulien臈 鈥�

member of the Lithuanian Morphological Society;
member of the European Anthropological Association;
member of the World鈥檚 Poultry Science Association.

Assoc. Prof. E. M. Jakimavi膷ien臈 鈥�

member of the Lithuanian Morphological Society;
member of the European Anthropological Association;
member of the International Auxological Society.

Assoc. Prof. 沤. Miliauskien臈 鈥�

member of the Lithuanian Morphological Society;
member of Paleopathology Association;
member of the European Anthropological Association;
member of the Lithuanian Society of Archaeology.

Assoc. Prof. L. Nedzinskien臈 鈥�

member of the Lithuanian Morphological Society.

Assoc. Prof. A. Suchomlinov 鈥�

member of the European Anthropological Association;
member of the International Auxological Society;
member of the Lithuanian Morphological Society.

Assoc. Prof. V. Tutkus 鈥�

member of European Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA);
member of International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS);
member of Lithuanian Association of Arthroscopic Surgeons;
member of Lithuanian Society of Orthopaedics and Traumatology;
member of Lithuanian Society of Plastic and Reconstructive Surgery.

Junior Assist., PhD student V. Luko拧aitis 鈥�

member of Lithuanian Association of Neurologists;
member of Lithuanian Society for Epileptology;
member of Lithuanian Stroke Association.

Junior Assist. R. Mackevi膷ien臈 鈥�

member of the Lithuanian Morphological Society;
member of the Lithuanian Ornithological Society.

Junior Assist., PhD student R. Mork奴nien臈 鈥�

member of Lithuanian Pediatric Society;
member of European Anthropological Association;
member of the International Auxological Society.

Assist. D. Bandzevi膷ien臈, Lect. R. Jacevi膷i奴t臈 鈥�

members of the Lithuanian Morphological Society.

Assist., PhD student K. Kuolien臈 鈥�

member of the European Anthropological Association;
member of Lithuanian Ophthalmological Society;
member of the Association for Research in Vision and Ophthalmology.

Assist. Dr. M. Leonavi膷i奴t臈-Klimantavi膷ien臈 鈥�

member of Lithuanian Society of Children鈥檚 Pulmonology;
member of Lithuanian Society of Allergy and Clinical Immunology;
member of European Respiratory Society.

Lect. A. Audickait臈 鈥�

member of the Lithuanian Dermatovenereology Society;
member of the European Academy of Dermatology and Venereology.

Lect. V. Bartu拧kien臈 鈥�

member of the European Anthropological Association;
member of the Lithuanian Morphological Society.

Lect. J. Janavi膷ius 鈥�

president of Lithuanian Hand Surgery and Rehabilitation Society Manus Lithuanica;
member of Lithuanian Foot Surgery Society;
member of International Federation of Societies for Surgery of the Hand;
member of European Foot and Ankle Society.

Lect. J. Jara拧奴nas 鈥�

member of European Society of Radiology;
member of Lithuanian Association of Radiologists.

Lect. K. Popov 鈥�

member of Lithuanian Society of Orthopaedics and Traumatology.

PhD student G. Laurinavi膷i奴t臈 鈥�

member of Lithuanian Ophthalmological Society;
European Society of Cataract and Refractive Surgeons.

PhD student A. Vaitiekus 鈥�

member of Lithuanian Society of Orthopaedics and Traumatology;
member of Lithuanian Foot Surgery Society;
member of European Foot and Ankle Association (EFAS);
member of Lithuanian Association of Arthroscopic Surgeons.

MOST IMPORTANT PARTICIPATION CASES OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

R. Jankauskas. Working group on identification of remains of leaders of 1863鈥�1864 uprisal.
R. Jankauskas. Working group on identification of remains of Soviet regime victims inhumed in Antakalnis cemetery.

CONSULTATIONS PROVIDED BY THE UNIT TO THE PUBLIC OR ECONOMIC ENTITIES

J. Tutkuvien臈. Regular consultations provided to public with regard to growth and development of children.

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

Information about changes (trends, factors, consequences, perspectives) in body image (in the newspaper Lietuvos 啪inios, November 21, 2018):

Information about evolutionary factors of nutrition and food consumption (in the magazine Edita, November, 2018, p. 16鈥�21).

Information about bioarchaeology in largest information portal in Lithuania:

Information about investigations of prominent historical personalities in the largest information portal in Lithuania:

Information on paleogenetics in the largest information portal in Lithania:

Information on the study of the mummies in Ferentillo in Italian news:

DEPARTMENT OF HUMAN AND MEDICAL GENETICS

2 Santari拧ki懦, LT-08661 Vilnius
Tel.: 250 1798, 250 1794
E-mail:
www

Head 鈥� Prof. Dr. Algirdas Utkus

STAFF

Professors: Dr. L. Cimbalistien臈 (part-time), Dr. A. Jakaitien臈 (part-time), Habil. Dr. V. Ku膷inskas (emeritus), Dr. A. Utkus (part-time).
Associate professors: Dr. L. Ambrozaityt臈 (part-time), Dr. E. Benu拧ien臈 (part-time), Dr. J. Kasnauskien臈 (part-time), Dr. A. Molyt臈 (part-time).
Assistant professors: Dr. A. Bankauskien臈 (part-time), Dr. N. Brat膷ikovien臈 (part-time), Dr. V. 艩liu啪as (part-time), Dr. A. Mork奴nien臈 (part-time), Dr. A. Matulevi膷ien臈 (part-time), Dr. B. Tumien臈 (part-time).
Senior researchers: Dr. E. Pranckevi膷ien臈 (part-time), Dr. E. Preik拧aitien臈 (part-time).
Researchers: Dr. 沤. Mald啪ien臈 (part-time), Dr. I. Domarkien臈 (part-time), Dr. V. Ginevi膷ien臈 (part-time), Dr. J. Su拧inskas (part-time), Dr. I. Kavaliauskien臈 (part-time), Dr. V. Mik拧tien臈 (part-time).
Research assistants: Dr. J. Songailien臈 (part-time), Dr. T. Petr臈nas (part-time),
Dr. T. Ran膷elis (part-time), J. Arasimavi膷ius (part-time), I. Ba拧kirova (part-time), R. Me拧kien臈, E. Siavrien臈 (part-time), B. Aleksi奴nien臈 (part-time), A. Urnikyt臈.
Teaching assistant: B. Burnyt臈 (part-time).
Lecturers: K. Baronas, (part-time), G. 沤ukauskait臈 (part-time), N. Krasovskaja (part-time), D. Vansevi膷i奴t臈 (part-time).
Doctoral students: B. Aleksi奴nien臈, B. Burnyt臈, A. Urnikyt臈, L. Pranck臈nien臈, E. Siavrien臈, R. Laukien臈, E. Dagyt臈, G. 沤ukauskait臈.
Genetic scientific group of students: scientific leader 鈥� Dr. E. Preik拧aitien臈, coordinator 鈥� student Kamil臈艩iauryt臈; 18 members of students.

RESEARCH INTERESTS

Genetic variation inter- and intra- population of Lithuania
Genomics of intellectual disability
Genetic analysis of hereditary phenotypes 鈥� genetic characterization of human phenome, genome and regulome

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Diversity of Human Genome, Its Origin and Phenotypical Realization. Prof. Dr. A.Utkus. 2014鈥�2018.

The research of the specific genetic loci for neurodevelopmental disorders and intellectual disability, severe dysmorphic phenotypes, and other challenging hereditary phenotypes were performed investigating physical mapping and possible DNA variants function. Genetic variation analysis of the Lithuanian population considering genomic factors within the population groups was carried out and compared to the other European and world populations.

Main publications:

Pranck臈nien臈, L., Jakaitien臈, A., Ambrozaityt臈, L., Kavaliauskien臈, I., Ku膷inskas, V. 2018. Insights into de novo mutation variation in Lithuanian exome. Frontiers in Genetics, vol. 9, no 315, p. 1鈥�8, doi: 10.3389/fgene.2018.00315.

Aleksi奴nien臈, B., Preik拧aitiene, E., Mork奴nien臈, A., Ambrozaityt臈, L., Utkus, A. 2018. A de novo 1q22q23.1 interstitial microdeletion in a girl with intellectual disability and multiple congenital anomalies including congenital heart defect. Cytogenetic and Genome Research, vol. 154, no 1, 1鈥�6, doi: 10.1159/000486947.

Gueneau, L., Fish, R. J., Shamseldi, H. E., et al. [from VU Faculty of Medicine: Preiksaitiene, E., Ambrozaityte, L., Cimbalistien臈, L., Ku膷inskas, V.]. 2018. KIAA1109 variants are associated with a severe disorder of brain development and arthrogryposis. American Journal of Human Genetics, vol. 102, iss. 1, p. 116鈥�132, doi: 10.1016/j.ajhg.2017.12.002.

National Research Projects

Deciphering the Genetic Architecture of Intellectual Disability and Congenital Anomalies (INGENES). Dr. E. Preik拧aitien臈. 2017鈥�2020.

Clinical data of the project INGENES participants have been collected with focus to family history and pedigree, personal history, physical examination, imaging and laboratory diagnostics performed before enrolment. Venous blood samples have been be collected for DNA and RNA extraction. Samples of skin biopsy have been obtained and fibroblasts have been cultivated. Whole exome sequencing was performed for affected individuals and their I degree relatives in cases of unknown etiology ID/CA. Gene expression was evaluated using quantitative RT-PCR. Sanger sequencing was used for confirmation of pathogenicity of novel splicing variants. The obtained results have been disseminated during national and international conferences. Three articles have been submitted for publication.

Prevalence of Prenatal Alcohol Exposure in Lithuania and the Effect of Prenatal Alcohol Exposure to Metabolism of Newborns (ALKOMET LT). Prof. Dr. A. Utkus. 2017鈥�2018.

The aim of the project was to determine the total prevalence of alcohol consumption among pregnant women in Lithuania. The performed investigation has revealed that 3% of pregnant women consumed alcohol during last weeks of pregnancy, while 0.15% women consumed alcohol in large amounts, as PEth concentration in these newborn DBS was as high, as reported in adults after alcohol abuse. It was found that 92% of abstinent pregnant woman and 72% of non-abstinent gave birth to full-term babies. In the non-abstinent group more babies (14%) having body mass less than 2500 g were born compared to abstinent group (2%).

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Thermo Fisher Scientific Baltics (Lithuania)
Lithuanian Olympic Sports Center (Lithuania)
University of Lausanne (Swiss Confederation)
Department of Medical Research Kaohsiung Chang-Gung Memorial Hospital, Taiwan (China)
Division of Medical Genetics Department of Pediatrics, Keio University School of Medicine, Tokyo (Japan)
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX (USA)

OTHER SCIENTIFIC ACTIVITIES

Prof. Dr. A. Utkus 鈥�

member of the Executive Committee of The Association of Medical Schools in Europe (AMSE);
member of the National Health Council;
editorial board member of the journal Laboratorin臈 medicina (Laboratory Medicine);
member of the Lithuanian Society of Human Genetics,
President of the Lithuanian Society of Human Genetics,
editorial board member of the journal Sveikatos mokslai (Lietuva);
member of the European Society of Human Genetics, www.eshg.org;
member of the American Society of Human Genetics, www.ashg.org;
board member of Ministry of Health of the Republic of Lithuania;
coordinator of ERN-RND (European Reference Network on Rare Neurological Diseases).

Prof. Habil. Dr. V. Ku膷inskas 鈥�

council member of the Federation of European Academies of Medicine,
chairperson of the division of Biology, Medicine and Geosciences of the Lithuanian, Academy of Sciences,
member of the Presidium of the Lithuanian Academy of Sciences,
member of the Lithuanian Academy of Sciences,
editorial board member of the journal Laboratorin臈 medicina (Laboratory Medicine),
editorial board member of the Journal of Applied Genetics (Poland),
editorial board member of the journal Medicina (Medicine);
editorial board member of the Journal Medical Genetics (Russia);
editorial council member of the Journal Acta Medica Lituanica;
editorial board member of the Balkan Journal of Medical Genetisc (Makedonija);
consultant on medical genetics, Ministry of Health of the Republic of Lithuania;
board member of the Lithuanian Society of Human Genetics,
member of the European Society of Human Genetics, www.eshg.org;
member of the American Society of Human Genetics, www.ashg.org;
member of Human Genome Organization (HUGO);
chairman of the committee of Master study programme Medical Genetics at 91桃色.

Prof. Dr. L. Cimbalistien臈 鈥�

member of the Society for the Study of Inborn Errors of Metabolism (SSIEM),
member of the Lithuanian Society of Human Genetics (chairperson of Committee of Financial Supervisory Commission),
member of the Lithuanian Doctors鈥� Union,

Prof. Dr. A. Jakaitien臈 鈥�

member of Lithuanian Mathematical Society,
board member of Lithuanian Statistics Society,
member of International Biometric Association,
country representative of International Biometric Association in Nord Baltic Region,
member of International Epidemiological Association.

Dr. E. Benu拧ien臈 鈥�

member of the Lithuanian Society of Human Genetics (chairperson of Committee of Professional Competenc eand Ethics),
member of the European Society of Human Genetics, www.eshg.org;
member of the Lithuanian Society of Doctors.

Dr. J. Kasnauskien臈 鈥�

member of the Lithuanian Society of Human Genetics,
member of the European Society of Human Genetics, www.eshg.org;
board member of Lithuanian Society of Laboratory Medicine.

Dr. E. Pranckevi膷ien臈 鈥�

member of Canadian Society of Molecular Biosciences,
member of American Association of Advancement of Science,
member of International Neural Network Society,
member of the Lithuanian Society of Human Genetics;
member of the European Society of Human Genetics, www.eshg.org;

Dr. L. Ambrozaityt臈 鈥�

member of the Lithuanian Society of Human Genetics (board member),
member of the European Society of Human Genetics, ;
member of the American Society of Human Genetics, .

Dr. I. Domarkien臈 鈥�

member of the Lithuanian Society of Human Genetics,

Dr. V. Ginevi膷ien臈 鈥�

member of the Lithuanian Society of Human Genetics,
member of the European College of Sport Science,
member of the Baltic Sport Science Society, ;
member of the Lithuanian Federation of Sports Medicine,

Dr. I. Kavaliauskien臈 鈥�

member of the Lithuanian Society of Human Genetics,
member of the European Society of Human Genetics, .

Dr. 沤. Mald啪ien臈 鈥�

member of the Lithuanian Society of Human Genetics,
member of the European Society of Human Genetics, www.eshg.org;
National scholarship program of the World Federation of Scientists.

Dr. A. Matulevi膷ien臈 鈥�

member of the European Society of Human Genetics, www.eshg.org;
member of the Committee for Orphan Medicinal Products (COMP);
member of the Lithuanian Society of Human Genetics, (board member of the Committee of Financial Supervisory Commission),
member of the Lithuanian Society of Doctors;
coordinator of ERN-ITHACA (Network of Intellectual Disability and Congenital Malformations).

Dr. A. Mork奴nien臈 鈥�

member of the Lithuanian Society of Human Genetics,

Dr. A. Molyt臈 鈥�

member of the Lithuanian Computer Society.

Dr. J. Songailien臈 鈥�

member of the Lithuanian Society of Human Genetics,
member of the International Society for Neonatal Screening,
member of the Society for the Study of Inborn Errors of Metabolism (SSIEM),
president of the Baltic Metabolic Group,
National representative of Lithuania in ERNDIM/EuroGenTest (ERNDIM- European Research Network for Evaluation and Improvement of Screening, Diagnosis and Treatment of Inherited Disorders of Metabolism; EuroGentest - EU-funded Network of Excellence),

Dr. V. 艩liu啪as 鈥�

member of the Lithuanian Society of Human Genetics,
member of the European Society of Human Genetics, .

Dr. E. Preik拧aitien臈 鈥�

member of the Lithuanian Society of Human Genetics,

Dr. J. Su拧inskas, Dr. A. Bankauskien臈 鈥�

members of the Lithuanian Mathematical Society.

Dr. V. Mik拧tien臈 鈥�

member of the Lithuanian Society of Human; Genetics,
member of the European Society of Human Genetics, www.eshg.org.

Dr. B. Tumien臈 鈥�

board member of the European Society of Human Genetics,
European Reference Network Board of Member States, Lithuanian representative;
member of the Lithuanian Society of Human Genetics,
member of the Society for Studies of Inborn Errors of Metabolism, SSIEM;
board member of Baltic Metabolic Group;
member of Lithuanian Child Neurology Association;
member of Lithuanian Society of Epileptology;
member of Lithuanian Society of Neurosciences;
Orphanet Operating Committee member, Encyclopedia Editor.

B. Aleksi奴nien臈 鈥�

member of the Lithuanian Society of Human Genetics,
member of the European Society of Human Genetics, .

B. Burnyt臈 鈥�

member of the Lithuanian Society of Human Genetics,
member of the European Society of Human Genetics, ;
member of the American Society of Human Genetics, ;
member of the Society for Studies of Inborn Errors of Metabolism, SSIEM
Orphanet information scientist.

A. Urnikyt臈 鈥�

member of the European Society of Human Genetics, ;
member of the American Society of Human Genetics, .

R. Me拧kien臈 鈥�

member of the Lithuanian Society of Human Genetics,

E. Siavrien臈 鈥�

member of the Lithuanian Stem Cell Research Association;
member of the Lithuanian Society of Human Genetics,

L. Pranck臈nien臈 鈥�

member of the European Society of Human Genetics, .

J. Arasimavi膷ius 鈥�

member of European Academy of Dermatology and Venereology,
member of Lithuanian Society of Dermatovenereologists,
member of European Association of Dermato Oncology,
member of International Dermoscopy Society,
member of European Nail Society,

MOST IMPORTANT NATIONAL AND INTERNATIONAL AWARDS RECEIVED FOR R&D ACTIVITIES

Dr. E. Preik拧aitien臈鈥� scholarship of Lithuanian Academy of Sciences for young researchers, 2018鈥�2019.

MOST IMPORTANT PARTICIPATION CASES OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

Dr. L. Ambrozaityt臈鈥� nominated representative to the Working Group on the White Paper on good genomic practice Towards access to at least 1 million sequenced genomes in the European Union by 2022.

CONSULTATIONS PROVIDED BY THE UNIT TO THE PUBLIC OR ECONOMIC ENTITIES

Dr. I. Domarkien臈鈥� consultation to the publisher BALTO leidybos namai UAB on the interpretation of the book Naturalist by Andrew Mayne.

LIST OF THE MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

Project Prevalence of prenatal alcohol exposure in Lithuania and the effect of prenatal alcohol exposure on metabolism of newborns (ALKOMET LT) popularisation activities:

91桃色 science promotion journal Spectrum: Tyrimas atskleid臈鈥� savo k奴dikio sveikata Lietuvoje rizikuoja 3 proc. n臈拧膷i懦j懦 (The research study determined that 3% of pregnant women risk the health of their child in Lithuania). Spectrum 2(28), 2018.
Monthly journal for young families Mamos 啪urnalas: N臈拧tumas+alkoholis =nesuderinama (Pregnancy+alcohol=incompatible). Mamos 啪urnalas, no. 12, 2018.
Monthly journal for young parents Tavo vaikas: La拧as po la拧o (Drop by drop). Tavo vaikas, no.1, 2019.

DEPARTMENT OF PATHOLOGY, FORENSIC MEDICINE AND PHARMACOLOGY

21 M. K. 膶iurlionio, LT-03101Vilnius
Tel. 239 8727
E-mails:

Head 鈥� Prof. Dr. Arvydas Laurinavicius

STAFF

Professors: Dr. D. Characiejus, Dr. V. Grabauskien臈, Dr. J. Gulbinovi膷, Dr. A. Laurinavi膷ius, Dr. A. 沤virblien臈.
Associate professors: Dr. A. Barakauskien臈, Dr. E. Kaz臈nait臈, Dr. V. Kvedarien臈, Dr. A. Laurinavi膷ien臈, Dr. J. Stasi奴nien臈, Dr. E. 沤urauskas.
Junior assistants: T. Baltr奴nas, V. Baltr奴nien臈, Dr. J. Besusparis, J. Bublevi膷, S. Chmieliauskas, E. Jurevi膷ien臈, D. Stravinskien臈, R. 艩imakauskas.
Lecturers: A. Barkus, A. Bau拧ys, S. Budrikien臈, I. Bunevi膷i奴t臈, A. 膶erkauskait臈, J. Drachneris, R. Dzetaveckien臈, A. Garnelyt臈, A. Gintautas, R. B. Grinevi膷i奴t臈, S. Jokubauskien臈, R. Katkus, D. Linkevi膷i奴t臈-Ulinskien臈, M. L臈ckien臈, E. Majauskien臈, J. Maneikyt臈, U. Mickys, V. Nari奴nait臈, D. Petro拧ka, I. Vencevi膷i奴t臈, D. Ramanauskait臈, S. Stankevi膷i奴t臈.
Assistants: Dr. S. Laima, Dr. I. Lisauskien臈.
Senior researcher: Dr. A. Rasmusson.
Researcher: Dr. D. Bironait臈.
Doctoral students: T. Baltr奴nas, V. Baltr奴nien臈, J. Bublevi膷, S. Chmieliauskas, A. 膶erkauskait臈, I. Drejerien臈, D. Dudutien臈, I. Ka啪ukauskien臈, D. Linkevi膷i奴t臈-Ulinskien臈, S. Ma啪eikien臈, R. 艩imakauskas, D. 沤il臈nait臈.

RESEARCH AREAS

Development of the new diagnostic and prognostic molecular markers and tools for their quantification in the tissues. Diagnostic value of pathology tests and efficiency of cancer prevention programs
Development of the predictive, preventive, personalized and prognostic biomarkers of the diseases
Genesis and gnoseology of violence
Changes in cardiovascular medicines utilization, morbidity, and mortality from cardiovascular disease in Lithuania

RESEARCH INTERESTS

Inflammatory cardiomyopathy: prognostic biomarkers of heart failure

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Development of the New Diagnostic and Prognostic Molecular Markers and Tools for their Quantification in the Tissues. Diagnostic Value of Pathology Tests and Efficiency of Cancer Prevention Programs. Prof. Dr. A. Laurinavi膷ius.

Digital image analysis-based evaluation of breast cancer proliferative activity was validated in the international Ki67 working group study. The results were published in the modern pathology and presented at San Antonio Breast Cancer symposium 2018 (the data is prepared for publication).

Main publications:

Rimm, D.L., Leung, S.C.Y., McShane, L.M., Bai, Y., Bane, A.L., Bartlett, J.M.S., Bayani, J., Chang, M.C., Dean, M., Denkert, C., Enwere, E.K., Galderisi, C., Gholap, A., Hugh, J.C., Jadhav, A., Kornaga, E.N., Laurinavicius, A., Levenson, R., Lima, J., Miller, K., Pantanowitz L., Piper T., Ruan, J., Srinivasan, M., Virk, S., Wu, Y., Yang, H., Hayes, D.F., Nielsen, T.O., Dowsett, M. 2018. An international multicenter study to evaluate reproducibility of automated scoring for assessment of Ki67 in breast cancer. Modern Pathology, vol. 32, no 1, 59鈥�69, doi: 10.1038/s41379-018-0109-4.

Balazs, A.C.S., Leung, S. C. Y., Pelekanou, V., Bai, Y., Martinez-Morilla, S., Toki, M., Chang, M.C., Gholap, A., Jadhav, A., Hugh, J.C., Bigras, G., Laurinavicius, A., Augulis, R., Levenson, R., Todd, A., Piper, T., Virk, S., Van der Vegt, B., Hayes D.F., Dowsett, M., Nielsen, T. O. and Rimm, D.L. 2018. Analytical validation of an automated digital scoring protocol for Ki67: international multicenter collaboration study. San Antonio Breast Cancer symposium 2018.

New opportunities of cancer tissue segmentation and glomerular detection, enabled by deep learning techniques, were explored and published.

Morkunas, M., Treigys, P., Bernataviciene, J., Laurinavicius, A., Korvel, G. 2018. Machine learning based classification of colorectal cancer tumour tissue in whole-slide images. Informatica, vol. 29, no 1, 75鈥�90 4.

Gallego, J., Pedraza, A., Lopez, S., Steiner, G., Gonzalez, L., Laurinavicius, A., Bueno, G. 2018. Glomerulus classification and detection based on convolutional neural networks. Journal of Imaging, vol. 4, iss 1, doi: 10.3390/jimaging4010020.

Development of the Predictive, Preventive, Personalized and Prognostic Biomarkers of the Diseases. Prof. V. Grabauskien臈.

We evaluated whether circulating adiponectin (APN) level can be an independent predictors of composite outcome: death, left ventricle assist device implantation and heart transplantation in patients with non-ischemic dilated cardiomyophathy (DCM). We found that an increased level of circulating APN was associated with higher mortality and may be prognostic marker in the DCM with advanced heart failure (HF) patients. Combination of several sera (APN, BNP) and echocardiographic (average global strain) markers may increase the HF predicting power for the DCM patients.

Genesis and Gnoseology of Violence. Assoc. Prof. Dr. J. Stasi奴nien臈. 2014鈥�2018.

Even though the majority of preventative programs are intended to decrease homicide rate, in dynamics, the numbers decrease insignificantly and remain high. It is clear that several preventative programs are needed aiming at diminishing alcohol consumption and population groups regarding their social background.

Main publications:

Chmieliauskas, S., Laima, S., Andriu拧kevi膷i奴t臈, G., Jurolaic, E., Jasulaitis, A. 2018. Homicide rates in Lithuania. Journal of Forensic Sciences, vol. 63, no 3, p. 724鈥�727, doi: 10.1111/1556-4029.13618

Chmieliauskas, S., Anu啪yt臈 Jogint臈, S., Liucvaikyt臈, J., Laima, S., Jurolaic, E., Ro膷ka, S., Fomin, D., Stasi奴nien臈, J., Jasulaitis, A. 2018. Importance of effusion of blood under the dura mater in forensic medicine: A STROBE 鈥� compliant retrospective study. Medicine, vol. 97, no 39, e12567, 1鈥�7, doi: 10.1097/md.0000000000012567.

Fomin, D., Baranauskait臈, V., Usavi膷ien臈, E., 艩umkovskaja, A., Laima, S., Jasulaitis, A., Minkuvien臈, Z.N., Chmieliauskas, S., Stasi奴nien臈, J. 2018. Human deaths from drug overdoses with carfentanyl involvement鈥攏ew rising problem in forensic medicine A STROBE-compliant retrospective study. Medicine, vol. 97, no 48, art. no e13449, p. 1鈥�4, doi: 10.1097/md.0000000000013449.

National Research Projects

Research Council of Lithuania. Novel Biomarkers for Individualized Therapy of Colon Cancer: Proteomics, Micrornomics and Clinics. Prof. Dr. A. Laurinavi膷ius, Dr. J. Besusparis.

Focused studies on potential chemotherapy resistance factors in colorectal cancer patients with carried out based on previously identified candidate biomarkers. In particular, significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells was explored and published. Clinical validation studies in the patient cohort collected are being performed and prepared for publication.

Main publication:

Kukcinaviciute, E., Jonusiene, V., Sasnauskiene, A., Dabkeviciene, D., Eidenaite, E., Laurinavicius, A. 2018. Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells hct116. Journal of Cellular Biochemistry, vol.119, no7, p. 5913鈥�5920, doi: 10.1002/jcb.26783.

Research Council of Lithuania (submitted). Simultaneous In Vivo Imaging of Lymphocytes and Tumor Cells. Prof. Dr. D. Characiejus.

Using in vivo bioluminescence imaging, the interaction between T lymphocytes and tumor cells will be analyzed. In particular, research is aimed at elucidating the role of T lymphocytes in control of tumor cell kinetics.

Main publication:

Jur拧臈nait臈, J., Girkontait臈, I., 艩iaurys, A., Mauricas, M., Characiejus, D. 2018. Intratumoral accumulation and clonal expansion may not be decisive for rejection of allogeneic tumors by CD8+ T-lymphocytes. Anticancer Res, vol. 38, no. 8, 4481鈥�4484, doi: 10.21873/anticanres.12751.

International Research Projects

EU SF Development of competences of scientists through world class level scientific research. Deep-Context Tissue Analytics for Integrated Pathology Modeling in Tumors and Kidney Allografts. Prof. dr. A. Laurinavi膷ius, Dr. A. Laurinavi膷ien臈, Dr. A. Rasmusson, Dr. B. Plancoulaine, Dr. R. Levenson, Dr. M. Shribak, Dr. KY. Jen.

The aim of the study is to develop novel tissue-based analytical assays for integrated modelling of tumor and kidney allograft pathology. Objective 1 is to explore tissue processing/data extraction approaches to discover unique digital signatures of tissue components and integrated pathology indicators. Objective 2 is to design and validate the 鈥渄eep-context鈥� tissue assays for selected analytical and clinical tasks to enable robust and affordable multidimensional modeling of tissue pathology.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Universit茅 de Caen Basse-Normandie (France)
Cancer Pathology Nottingham University (GB)
Brigham and Women鈥檚 Hospital, Harvard Medical School, Boston, MA (USA)
Ruprecht-Karls-universitat Heidelberg, EMBL (Germany)
University Hospital Gie脽en and Marburg (Germany)
Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University (Sweden)

OTHER SCIENTIFIC ACTIVITIES

Prof. Dr. A. Laurinavi膷ius 鈥�

member of the Clinical Nephrology Committee, Lithuanian Association of Nephrology, Dialysis, and Transplantation;
member of the European Society of Pathology;
vice-chairman of the board of the Lithuanian Society of Pathology;
editorial board member of the journal Medicina (Medicine);
editorial board member of the journal Diagnostic Pathology;
editorial board member of the journal Pathology Informatics;
management board chairman of Lithuanian Association of Health Informatics and Bioinformatics.

Prof. Dr. V. Grabauskien臈 鈥�

fellow of the European Society of Cardiology (FESC);
member of the European Association of Echocardiography (EAE) of the ESC;
member of the Heart Failure Association (HFA) of the ESC;
member of the American Society of Echocardiography;
UEMS (European Union of Medical Specialist) Diploma of European Cardiologist Nr.52546;
member of the European Association for Predictive, Preventive and Personalized Medicine (EPMA).

Prof. Dr. J. Gulbinovi膷 鈥�

member of Executive Committee of the European Association of Clinical; Pharmacology and Therapeutics (EACPT);
member of Cauncil of European Drug Utilisation Group (EuroDurg);
board member of Lithuanian Association of Clinical Pharmacology;
member of Pharmacovigilance Risk Assessment Committee of the European medicines Agency.

Prof. Dr. D. Characiejus 鈥�

National Representative of the European Association for Predictive, Preventive and Personalized Medicine (EPMA) in Lithuania;
editorial board member of the EPMA Journal;
member of the European Association for Cancer Research (EACR);
member of the European Society of Cancer Immunology and Immunotherapy (ESCII);
member of the Council of the Lithuanian Society of Immunology;
member of International Scientific Advisory Board.

Assoc. Prof. Dr. E. 沤urauskas, U. Mickys, D. Petro拧ka 鈥�

members of the Lithuanian Society of Pathology.

Assoc. Prof. Dr. A. Laurinavi膷ien臈 鈥�

president of Lithuanian Association of Pathology Technologists.

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

Jonusiene, V, Kukcinaviciute, E. 2018. Vaistams atsparios v臈啪in臈s l膮stel臈s 鈥� galvos奴kis mokslininkams. Literat奴ra ir menas, no. 19.

DEPARTMENT OF PHYSIOLOGY, BIOCHEMISTRY, MICROBIOLOGY AND LABORATORY MEDICINE

21 M. K. 膶iurlionio, LT-03101Vilnius
Tel. 239 8720
E-mail:

Head 鈥� Assoc. Prof. Dr. Dovil臈 Kar膷iauskait臈

STAFF

Professors: Dr. Z. A. Ku膷inskien臈, Dr. A. Abaravi膷ius, Dr. A. Kaminskas, Dr. V. Hendrixson.
Associate professors: Dr. D. Kar膷iauskait臈, Dr. V. Jablonskien臈, Dr. T. Ka膷ergius, Dr. R. Matuzevi膷ien臈, Dr, L. Bagdonait臈, Dr. D. Vitkus, Dr. S. Meidut臈鈥揂baravi膷ien臈.
Assistant professors: Dr. A. Ma啪eikien臈, Dr. A. Kirkliauskien臈, Dr. P. Kalesinskas, Dr. M. Baranauskas, Dr. V. Banys.
Junior assistants: M. Radzevi膷ius, 沤. Chomanskis, V. 沤臈kas, E. Mazgelyt臈.
Lecturers: Dr. D. Pa拧kevi膷ien臈, I. Bikul膷ien臈, R. Petraitis, L. Vasiliauskait臈, E. Ostanevi膷i奴t臈.
Researchers: Dr. M. Brat膷ikoc, Dr. A. Linkevi膷i奴t臈, Dr. 沤. Daunoravi膷ius.
Doctoral students: M. Radzevi膷ius, V. 沤臈kas, E. Mazgelyt臈.

RESEARCH AREAS

Research and investigation of ethiopathogenetic mechanisms of atherosclerosis
Research and investigation of new methods in laboratory diagnostics of diseases
Investigation of nutrition and evaluation of new high quality food products with increased biological value to human health
Development of new antimicrobials for control of the medically important bacterial biofilms
Design of new molecular biology techniques for identification of the pathogenic and commensal microorganisms, genotyping, antimicrobial resistance and epidemiology

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Investigation of Environmental and Metabolic Factors in the Pathogenesis of Atherosclerosis. Prof. Z. A. Ku膷inskien臈. 2014鈥�2018.

The aim was to evaluate the etiopathogenetic relationship between different clinical manifestations of atherosclerosis: coronary heart disease and metabolic syndrome. Different diagnostic biomarkers in healthy individuals and patients with coronary heart disease and metabolic syndrome were investigated, including routine and new parameters.

Main publications:

Sakalauskait臈-Juodeikien臈, E., Armalien臈, G., Kizlaitien臈, R., Bagdonait臈, L., Giedraitien臈, N., Mickevi膷ien臈, D., Rastenyt臈, D., Kaubrys, G. F., Jatu啪is, D.2018. Detection of aquaporin鈥�4 antibodies for patients with CNS inflammatory demyelinating diseases other than typical MS in Lithuania. Brain and Behavior, vol. 8, no. 11, e01129, p. 1鈥�7, doi: 10.1002/brb3.1129.

Jassam N., Lake J., Dambrowska M., Queralto J., Rizos D., Vitkus D., et al. 2018. The European Federation of Clinical Chemistry and Laboratory Medicine syllabus for postgraduate education and training for Specialists in Laboratory Medicine: version 5 鈥� 2018. Clin Chem Lab Med, vol. 56(11), p. 1846鈥�1863.

Simundic A.M., Filipi P., Vratric A., Miler M., Gabal N.N., Vitkus D., et al. 2018. Patient鈥檚 knowledge and awareness about the effect of the over-the-counter (OTC) drugs and dietary supplements on laboratory test results: a survey in 18 European countries. Clin Chem Lab Med,

Human Cytomics: Research opf Diagnostic, Predictive and Treatment Monitoring Markers and Analysis Methods for Cellular Diseases. Prof. Z. A. Ku膷inskien臈, Assoc. Prof. R. Matuzevi膷ien臈. 2014鈥�2018.

Optimisation of flow cytometry for the diagnostics and minimal residual disease detection of haematological disorders and research of the new methods for leukemic cell phenotyping.

Main publications:

Tesi, B., Rascon, J., Chiang, S.C.C., Burnyte, B., L枚fstedt, A., Fasth, A., Heizmann, M., Juozapaite, S., Kiudeliene, R., Kvedaraite, E., Miseviciene, V., Muleviciene, A., M眉ller, M.L., Nordenskj枚ld, M., Matuzeviciene, R., Samaitiene, R., Speckmann, C., Stankeviciene, S., Zekas, V., Voss, M., Ehl S., Vaiciene-Magistris, N., Henter, J.I., Meeths, M., Bryceson, Y.T. 2018. A RAB27A 5'UTR structural variant associated with late-onset hemophagocytic lymphohistiocytosis and normal pigmentation. J Allergy Clin Immunol, vol. 142, no. 1, p. 317鈥�321, doi: 10.1016/j.jaci.2018.02.031.

Janeli奴nien臈, M., Janiulionien臈, A., Barzinskien臈, A., Ta拧k奴nait臈, D., Radzevi膷ius, M., Montrimait臈, M., Matuzevi膷ien臈, R., Kar膷iauskait臈, D. 2018. Applicability of flow cytometry for the diagnostics of myelodysplastic syndromes. Laboratorin臈 medicina, vol. 20, nr. 3, p. 183鈥�188.

Fundamental, Clinical and Epidemiological Studies on Pathogenic and Opportunistic Microorganisms Involved in the Pathogenesis of Human Diseases. Assoc. Prof. Dr. T. Ka膷ergius, Dr. S. Kiveryt臈. 2014鈥�2018.

Aim of this study was to investigate whether influenza neuraminidase inhibitor 鈥� zanamivir reduces pulmonary inflammation through inhibition of nitric oxide (NO) production in mice infected with influenza A virus. Results revealed that mice undergoing zanamivir treatment had less weight loss, viral replication, and lung damage, as well as significant reductions of local NO and inducible nitric oxide synthase mRNA synthesis (p<0.05). Thus, zanamivir is associated with an anti-inflammatory effect.

Main publications:

Zablockien臈, B., Ka膷ergius, T., Ambrozaitis, A., 沤urauskas E., Bratchikov M., Jurgauskien臈 L., Zablockis R., Gravenstein S. 2018. Zanamivir diminishes lung damage in influenza A virus-infected mice by inhibiting nitric oxide production. In Vivo, vol. 32, no 3, p. 473鈥�478, doi: 10.21873/invivo.11263.

V. Mathys, E. Roycroft, P. Raftery, R. Groenheit, D. B. Folksvardsen, D. Homorodean, E. Vasiliauskiene, L. Vasiliauskaite, C. Kodmon, M. J. van der Werf, F. Drobniewski, V. Nikolayevskyy. 2018. Time-and-motion tool for the assessment of working time in tuberculosis laboratories: a multicentre study. The International Journal of Tuberculosis and Lung Disease, vol. 22, iss. 4, p. 444鈥�451, doi: 10.5588/ijtld.17.0564.

Jagielski, T., Baku艂a, Z., Brzostek, A., Minias, A., Stachowiak, R., Kalita, J., Napi贸rkowska, A., Augustynowicz-Kope膰, E., 呕aczek, A., Vasiliauskiene, E., Bielecki, J., Dziadek, J. 2018. Characterization of mutations conferring resistance to rifampin in mycobacterium tuberculosis clinical strains. Antimicrob Agents Chemother, vol. 62, no 10, art. no e01093-18, [p. 1鈥�18], doi: 10.1128/AAC.01093-18.

National Research Projects:

Research Council of Lithuania. Impact of Chronic Stress on Atherosclerosis Process: Search and Investigation of New Biomarkers (No. MIP-050/2015). Prof. Z. Ku膷inskien臈, 2015鈥�2018.

Atherosclerotic cardiovascular diseases remain the major cause of deaths worldwide. In our work we are planning a complex investigation of effects of chronic psychological stress that are associated with atherosclerosis pathogenesis 鈥� dysfunction of hypothalamus-pituitary-adrenal (HPA) axis, activation of platelets, oxidative stress and inflammation. The evaluation of chronic stress will be evaluated not only using specific questionnaires, but also by accumulated amount of cortisol in hair and compared with the baseline secretion of cortisol determined by its concentration in saliva in the morning.

Diagnostic and Prognostic Value of Biomarkers for Patients Hospitalised Due to Acute Heart Failure: Prospective Observational Multicenter Cohort Study (MIP 049/2015). 2015鈥�2018. Leader 鈥� Prof. Dr. J. 膶elutkien臈, Investigator 鈥� Assoc. Prof. Dr. L. Bagdonait臈.

Project is carried out in conjunction with a research protocol of international GREAT consortium (Global Research on Acute Conditions Team). The aim was to evaluate the diagnostic and regional differences of novel biomarkers, their predictive value for risk of death and rehospitalisation in acute heart failure (AHF) patients. The first aggregated larger scale observational and biomarkers database of AHF patients in Lithuania will provide demographic data and trends of morbidity and mortality, as well as analysis of diagnostic and prognostic value of novel biomarkers in our region.

International Research Projects

Treatment Protocol for Children (1.0鈥�17.9 years of age) and Young Adults (18鈥�45 years of age) with Acute Lymphoblastic Leukemia NOPHO (Nordic Pediatric Hemato-Oncology) group, Flow Cytometry Coordinator of the Project in Lithuania: Assoc. Prof. R. Matuzevi膷ien臈.

91桃色 Children鈥檚 Hospital, Organizer of the Project 鈥� Nordic Society of Paediatric Haematology and Oncology (NOPHO), . Countries involved in the Project: Denmark, Sweden, Finland, Iceland, Norway, Lithuania, Estonia, Latvia. 6-year accrual period.

International Joint Project with AL-Qasemi Research Center, Israel: Effect of Rhus Plant Extract and Its Active Fractions on Biofilm Formation in Bacterial Systems. Assoc. Prof. Dr. T. Ka膷ergius, Prof. Dr. A. Rayan (Israel).

The aim of this study was to investigate whether the methanolic extract of Rhus coriaria L. fruits and its active fraction 鈥� methyl gallate inhibit Streptococcus mutans biofilm formation and acidogenicity. Results revealed that both 鈥� the extract of Rhus coriaria L. and the isolated methyl gallate significantly suppressed S. mutans biofilm formation and acidogenicity in comparison with the untreated bacteria. It is noteworthy that the bioactivities of Rhus coriaria L. extract and the isolated methyl gallate occurred in a dose-dependent manner. These findings are important for the development of new antibacterial agents.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

NOPHO (Nordic Pediatric Hemato-Oncology) group ()
Malm枚 University, Malm枚 (Sweden)
Clinical Institute of Chemistry, Zagreb (Croatia)
AL-Qasemi Research Center (Israel)
Department of Human and Medical Genetics of Faculty of Medicine of 91桃色 (Lithuania)
Centre of Pediatrics, Faculty of Medicine, 91桃色 (Lithuania)

OTHER SCIENTIFIC ACTIVITIES

Prof. Z. A. Ku膷inskien臈 鈥�

member of the Lithuanian Academy of Sciences;
member of the European Atherosclerosis Society (EAS);
member of the Board of the Lithuanian Society of Laboratory Medicine;
member of the Lithuanian Society of Human Genetics;
editor-in-chief of the journal Laboratorin臈 medicina (Laboratory Medicine);
editorial board member of the journals: Acta Medica Lituanica, Medicina, Medicinos teorija ir praktika, Sveikatos mokslai, Seminars in Cardiology.

Prof. A. J. Abaravi膷ius 鈥�

member of the National Committee of New Food Products;
member of the Lithuanian Society of Laboratory Medicine;
member of Lithuanian Physiological Society.

Prof. A. Kaminskas 鈥�

member of the Lithuanian Society of Laboratory Medicine.

Prof. V. Hendrixson 鈥�

member of the Lithuanian Society of Laboratory Medicine;
member of open Medical Institute Lithuanian Association of Neuroscience;
member of Federation of European Neuroscience Societies (FENS);
Honorary Professor of the Karaganda State Medical University.

Assoc. Prof. L. Bagdonait臈 鈥�&苍产蝉辫;

member of the Lithuanian Society of Laboratory Medicine;
member of the Lithuanian Society of Allergology and Clinical Immunology;

Assoc. Prof. V. Jablonskien臈 鈥�&苍产蝉辫;

editorial board member of the journal Laboratorin臈 medicina (Laboratory Medicine);
executive editor of the journal Laboratorin臈 medicina (Laboratory Medicine);
member of the Lithuanian Society of Laboratory Medicine.

Assoc. Prof. T. Ka膷ergius 鈥�

member of the Lithuanian Society of Medical Microbiologists.

Assoc. Prof. R. Matuzevi膷ien臈 鈥�

editorial board member of the journal Laboratorin臈 medicina (Laboratory Medicine);
member of the Lithuanian Society of Laboratory Medicine;
member of the Lithuanian Society of Haematology;
member of the Lithuanian Society of Allergology and Clinical Immunology;
member of the Lithuaninan Medical Association;
member of the European Society for Clinical Cell Analysis 鈥� ESCCA.

Assoc. Prof. D. Vitkus 鈥�

president of the Lithuanian Society of Laboratory Medicine;
National Representative at the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC);
National Representative at the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM);
National Representative at the Registration Commission of the European Society of Clinical Chemistry and Laboratory Medicine (EFLM);
member at large of the Board of Baltic Association of Laboratory Medicine;
member of the American Association for Clinical Chemistry;
corresponding Member of the Committee of Nomenclature for Properties and Units of Scientific Division of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC);
corresponding Member of the Committee of Reference Systems of Enzymes of Scientific Division of the IFCC;
corresponding Member of the Committee of Traceability in Laboratory Medicine of Scientific Division of the IFCC;
member of the ISTH;
corresponding member of the IFCC Task Force on Proficiency Testing;
corresponding member of the IFCC EMD Clinical Laboratory Management; Committee, Analytical Quality Committee;
corresponding member of the EFLM Working Group on Congresses and Postgraduate Education;
editorial board member of the journal Laboratory Medicine.

Assoc. Prof. D. Kar膷iauskait臈 鈥�

board member of Baltic Atherosclerosis Society;
board member of Lithuanian Laboratory Medicine Society;
member of European Atherosclerosis Society.

Assit. Prof. A. Kirkliauskien臈 鈥�

member of the Lithuanian Society of Laboratory Medicine;
member of the Lithuanian Society of Infectious Diseases.

Assit. Prof. S. Kiveryt臈 鈥�

member of the European Society of Clinical Virology;
member of the Lithuanian Society of Laboratory Medicine.

Assist. Prof. V. Banys 鈥�

board member and treasurer of the Lithuanian Society of Laboratory Medicine;
AACC (American Association for Clinical Chemistry);
ISTH (International Society on Thrombosis and Haemostasis);
CLSI (Clinical and Laboratory Standards Institute);
IFCC (International Federation of Clinical Chemistry and Laboratory Medicine) corresponding member of):
IFCC EMD Evidence-Based Laboratory Medicine Committee (C-EBLM);
IFCC EMD Harmonization of Interpretive Comments EQA Working Group (WG-ICQA);
IFCC EMD Laboratory Errors and Patient Safety Working Group (WG-LEPS);
IFCC SD Reference Intervals and Decision Limits Committee (C-RIDL);
IFCC Task Force on Ethics (TF-E);
IFCC Task Force for Young Scientists (TF-YS).

Assist. Prof. A. Ma啪eikien臈 鈥�

member of European Atherosclerosis Society (EAS);
member of the Lithuanian Society of Laboratory Medicine.

DEPARTMENT OF RADIOLOGY, NUCLEAR MEDICINE AND MEDICAL PHYSICS

2 Santari拧ki懦, LT-08661 Vilnius
Tel. 236 5177
E-mail:

Head 鈥� Prof. Dr. Algirdas Edvardas Tamo拧i奴nas

STAFF

Professors: Dr. A. E. Tamo拧i奴nas, Dr. N. R. Valevi膷ien臈.
Associate professors: Dr. J. Dementavi膷ien臈, Dr. S. Letautien臈.
Asisstants: Dr. A. Samuilis, Dr. B. Gricien臈, Dr. M. Mata膷i奴nas Dr. R. Briedien臈, Dr. R. Grigien臈, D. Valan膷ien臈.
Lecturer: J. Vai膷iulien臈.
Doctoral students: A. Neverauskien臈, K. Kristinaityt臈, A. Bajorinait臈, D. Jocius.
Students鈥� scientific groups of Radiology: scientific leader 鈥� Assist. Prof. N. R. Valevi膷ien臈, Student D啪. Jagminas; 33 members of the group.

RESEARCH AREAS

Creation of new functional and anatomical imaging techniques and evaluation of effectiveness for diagnostics of cardiovascular and oncological diseases
Estimation of iron overload in liver and heart on 3T MRI
Physical properties in vitro of metabolites using high resolution 9.4T NMR spectrometer
AI and deep learning applicaions in diagnostic imaging

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

New Functional and Anatomical Imaging Techniques in Cardiovascular and Oncology Diagnostics. Dr. A. E. Tamo拧i奴nas, Dr. N. R. Valevi膷ien臈.Dr. J. Dementavi膷ien臈, Dr. R. Briedien臈, Dr. S. Letautien臈, Dr. A. Samuilis, Dr. B. Gricien臈, Dr. M. Mata膷i奴nas. Prof. G. Kalinauskas, Dr. J. Valaikein臈, Dr. J. Dementavi膷ien臈. 2014鈥�2018.

The aim is to develop and evaluate new functional and anatomical imaging techniques in cardiovascular and oncology cancer diagnostics. Evaluation of the role of intracranial arterial stenosis and general atherosclerosis process for the patients undergoing surgery for coronary artery disease. The patients, who are undergoing surgery for coronary artery disease, are investigated before and after the surgery. The project includes questionnaire for the patients, general clinical, ultrasound examination of the brachiocephalic arteries and MRI/MRA without and with i/v contrast material of the brain, extracranial and intracranial arteries.

Main publications:

Cekauskas, A., Jakubauskas, M., Bielinis, A., Vajauskas, D., Zelvys, A. 2018. Prognostic factors of laparoscopic Anderson-Hynes pyeloplasty in treatment of ureteropelvic junction obstruction: A pilot study. European Urology Supplements, vol. 17, Iss. 5, e2206.

Neverauskiene, A., Maciusovic, M., Burkanas, M., Griciene, B., Petkevicius, L., Zaleckas, L., Tamosiunas, A., Venius, J. 2018. Image based simulation of the low dose computed tomography images suggests 13鈥痬As 120鈥痥V suitability for non-syndromic craniosynostosis diagnosis without iterative reconstruction algorithms. Eur J Radiol, vol. 105, p. 168鈥�174. doi: 10.1016/j.ejrad.2018.06.005.

Glaveckaite S., Uzdavinyte-Gateliene E., Petrulioniene Z., Palionis D., Valeviciene N., Kalinauskas G., Serpytis P., Laucevicius A. 2018. Predictors of ischaemic mitral regurgitation recurrence in patients undergoing combined surgery: additional value of cardiovascular magnetic resonance imaging. Interact Cardiovasc Thorac Surg., vol. 27(2), p. 222鈥�228, doi: 10.1093/icvts/ivy054. PubMed PMID: 29534177

Kristinaityt臈, K., Mar拧alka, A.N., Dagys, L., Aidas, K., Doroshenko, I., Vaskivskyi, Y., Chernolevska, Y., Pogorelov, V., Valevi膷ien臈, N.R., Balevicius, V. 2018. NMR, Raman, and DFT study of lyotropic chromonic liquid crystals of biomedical interest: tautomeric equilibrium and slow self-assembling in sunset yellow aqueous solutions. Journal of Physical Chemistry B. Washington, vol. 122, iss. 12, p. 3047鈥�3055, doi: 10.1021/acs.jpcb.8b00350.

National Research Projects

Research project Multi-Parametric MRI For Glial and Metastatic Brain Tumors. Assoc. Prof. S. Letautien臈. 2013鈥�2019.

Value of multi-parametric MRI biomarkers for glial brain tumors morphology and physiology. Assessment of glial brain tumors morphology and physiology by multi-parametric MRI biomarkers. The purpose of this study is to compare MRI perfusion, spectroscopy and tractography findings with tumour histological and molecular biology examination. We want to find if there are any specific MRI markers which can help determine histological tumor type and grade and predict its behaviour. Trial aim is to evaluate accuracy and applicability of multiparametric MRI biomarkers for diagnosis of brain tumours histological type, differential grade and neovascularisation assessment.

International Research Project. Euro CMR Registry Project. Prof. N.R. Valevi膷ien臈.

The European Cardiovascular Magnetic Resonance (EuroCMR) Registry is an initiative of the ESC Working Group Cardiovascular Magnetic Resonance. Enrolment of patients on a European level started in March 2009, resulting in the largest database on the clinical use, the impact on patient management, image quality and safety of cardiovascular MR (CMR) available so far. Including the German pilot phase (2007鈥�2009) 31.500 patients from 58 centers in 15 countries all over Europe have been collected. In addition to the questionnaire of the pilot phase, dedicated scientific issues will be addressed by individual additional protocols.

Joint 91桃色 and CERN cooperation project: Optimization of Ionizing Radiation Exposure in Radiology and Nuclear Medicine. Prof. A. E. Tamo拧i奴nas. 2016鈥�2018.

Objectives of the project are to create new diagnostic guidelines and optimize CT and Nuclear mecine imaging techniques. In 2017, we collected ionizing radiation exposure data fro one CT scanner, analysed exposure profiles, preliminary data were presented in Baltic Congress of Radiology 2016. At the end of 2017鈥�18 collected data should be published.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

SATT LUTECH & Universit茅 Pierre et Marie Curie (France)

OTHER SCIENTIFIC ACTIVITIES

Prof. A. E. Tamosiunas 鈥�

board member of Lithuanian Radiologists鈥� Association;
board member of Lithuanian Ultrasound Assocation;
member of European Society of Radiology.

Assoc. Prof. J. Dementavi膷ien臈 鈥�

editorial board member of the journal Theory and Practice in Medicine;
vicepresident of Lithuanian Radiologists鈥� Association;
member of European Society of Radiology;
member of European Society of Neuroradiology;
member of International Society of Magnetic Resonance in Medicine;
member of Radiology Society of North America;
social Advicer to Health Care Minister of Lithuania;
lecturer at continuing and advanced education courses at 91桃色 in Neuroradiology, Chest, Abdominal, Musculosceletal Imaging;
member of Research Committee at European Society of Radiology.

Assist. Prof. Dr. R. Briedien臈 鈥�

managing editor of the journal Acta Medica Lituanica.

Assist. Prof. R. Grigien臈 鈥�

editorial board member of the journal World Journal of Surgical Oncology.

INSTITUTE OF CLINICAL MEDICINE

CLINIC OF OBSTETRICS AND GYNECOLOGY

2 Santari拧ki懦, 08661 Vilnius
Tel.: 2501484; 2501487
E-mail

Head 鈥� Prof. Dr. Diana Rama拧auskait臈

STAFF

Professors: Dr. D. Rama拧auskait臈, Dr. G. S. Dr膮sutien臈, Dr. N. Drazdien臈, Dr. 沤. Bumbulien臈, K. Ma膷iulien臈 (prof. of partnership).
Associate professors: Dr. A. Arlauskien臈, Dr. D. Bartkevi膷ien臈, Dr. D. Lau啪ikien臈, Dr. M. 艩ilk奴nas, Dr. J. Zakarevi膷ien臈 .
Assistants: Dr. D. Bu啪inskien臈, Dr. V. Rudaitis, A. Am拧iejien臈, V. Paliulyt臈.
Junior assistant: K. Norvilait臈.
Lecturers: I. Daunoravi膷ien臈, Dr. G. Dom啪a.
Doctoral students: 沤. Sabonyt臈-Bal拧aitien臈, G. Bal膷i奴nien臈, K. Norvilait臈.

RESEARCH INTERESTS

Health of mother and fetus: physiology and pathology.

RESEARCH PROJECTS CARRIED OUT IN 2018

Project Supported by University Budget

Health of Mother and Fetus: Physiology and Pathology. Prof. Dr. G. S. Dr膮sutien臈. 2014鈥�2018.

Female age is the main and most important predictor of IVF outcome. Increasing female age decreases pregnancy and delivery rates after ART. The best results are achieved in women under 36 years of age. Obesity, especially central type, has a negative impact on pregnancy and delivery rates after ART. Increasing BMI and WHR increases miscarriage rate after ART. Increasing female height increases pregnancy and delivery rates after ART. Physiological indices of the uterine size over a period of two months after childbirth vary according to the number of childbirths in the past and last for more than six weeks.

Main publications:

Einikyt臈, R., Dapkevi膷i奴t臈, A., D啪enkevi膷i奴t臈, V., Kasnauskien臈 S., 艩apoka, V., Rama拧auskait臈, D. 2018. The importance of angiogenic and antiangiogenic biomarkers in pathogenesis and early diagnosis of preeclampsia. Clinical and Experimental Obstetrics & Gynecology, vol. 45, iss. 4, p. 485鈥�492.

Tutkuvien臈, J., Ju拧kait臈, A., Katinait臈, J., 艩ilov臈, S., Dr膮sutis, J., Sargautyt臈, R., Rama拧auskait臈, D., Dr膮sutien臈, G.S. 2018. Body image issues in Lithuanian females before and during pregnancy. Anthropologischer Anzeiger, vol. 75, no. 1, p. 9鈥�17, doi: 10.1127/anthranz/2018/0779.

沤ulpait臈, R., Bumbulien臈沤. 2018. Reproductive health of female childhood cancer survivors. Ginekologia Polska, vol. 89, iss. 5, p. 280鈥�286, doi: 10.5603/GP.a2018.0048.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Zurich University (Switzerland)
University of Gdansk (Poland)
Warshaw Medical University (Poland)

OTHER SCIENTIFIC ACTIVITIES

Prof. G. S. Dr膮sutien臈 鈥�

editorial board member of the journal Lietuvos chirurgija (Lithuanian Surgery).

Prof. N. Drazdien臈 鈥�

editorial board member of the journal Lietuvos aku拧erija ir ginekologija (Lithuanian Obstetrics & Gynecology);
board member of Lithuanian Pediatric Society and Vilnius Pediatric Society;
head of Lithuanian section of German-Baltic Physician Society.

Prof. D. Rama拧auskait臈 鈥�

president of Lithuanian Society of Obstetricians Gynecologists, ();
editorial board member of the journal Lietuvos aku拧erija ir ginekologija (Lithuanian Obstetrics & Gynecology;
organizing committee board member of the national conference Aesthetic and reconstructive gynecology: the present and perspective, March 08, 2018,
organizing committee board member of the international conference and workshops Tendency of caesarian section in XXI century, April 30, 2018,
organizing committee board member of the international conference and workshops Hysteroscopy and actual problems of infertility, June 07鈥�08, 2018,
organizing committee board member of the national conference Diagnostic and treatment of hyperandrogenism leading diseases, August 21, 2018,
organizing committee board member of the national conference Diagnostic and treatment of deep endometriosis, October 25, 2018, .

Prof. 沤. Bumbulien臈 鈥�

head of section of Lithuanian Society of Obstetricians Gynecologists;
board member of Vilnius Medical Society;
president-elect of EURAPAG, European Association of Paediatric and Adolescent Gynaecology,
organizing committee board member of the international conference 11th Athens Congress on Women鈥檚 Health & Disease Preconception to Menopause, Athens, Greece, September 06鈥�08, 2018;
international editorial board member of the journal Wiadomo艣ci Lekarskie;
international advisory board member of the journal Pediatric and Adolescent Reproductive Health,
editorial board member of the journal Lietuvos aku拧erija ir ginekologija (Lithuanian Obstetrics & Gynecology);
head of editorial board of the journal Ginekologijos aktualijos.

Assoc. Prof. A. Arlauskien臈 鈥�

board member and treasurer of Lithuanian Society of Obstetricians Gynecologists;
editorial board member of the journal Lietuvos aku拧erija ir ginekologija (Lithuanian Obstetrics & Gynecology;
member of International Society of Ultrasound in Obstetrics and Gynecology, www.isuog.com;
director of Ian Donald School of Medical Ultrasound branch for Lithuania, www.iandonaldschools.com.

Assoc. Prof. M. 艩ilk奴nas 鈥�

head of Vilnius region Society of Obstetrics and Gynecology;
board member of Lithuanian Society of Obstetricians Gynecologists;
organizing committee board member of the national conference European week of cervical cancer prophylaxis, January 25, 2018,
organizing committee board member of the national conference Infections in obstetrics and gynecology: news and rare clinical cases, March 16, 2018,
organizing committee board member of the international conference and workshops Hysteroscopy and actual problems of infertility, June 07鈥�08, 2018,
Assoc. Prof. D. Bartkevi膷ien臈鈥�
organizing committee board member of the international conference and workshops Hysteroscopy and actual problems of infertility,

Dr. V. Paliulyt臈 鈥�

board member of Vilnius region Society of Obstetricians Gynecologists.

MOST IMPORTANT NATIONAL AND INTERNATIONAL AWARDS RECEIVED FOR R&D ACTIVITIES

Prof. N. Drazdien臈. St. Christopher鈥檚 statuette for Merits in Health Care.

Assoc. Prof. A. Arlauskien臈. FIGO (International Federation of Gynecology and Obstetrics) Award in recognition of Women Obstetrician/Gynecologists. www.figo.org

Dr. V. Paliulyt臈. 1st place in contest The best scientific work introduced in clinical practice in 2018 organized by Vilnius Medical Society.

MOST IMPORTANT PARTICIPATION CASES OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

Prof. D. Rama拧auskait臈 - expert obstetrician gynecologist of the Ministry of Health, Republic of Lithuania;

Prof. D. Rama拧auskait臈 - member of Integrated Health Care Management Committee of Perinatology, Ministry of Health, Republic of Lithuania;

Prof. D. Rama拧auskait臈 - member of Lithuania Bioethical Committee, biomedical research experts group;

Prof. D. Rama拧auskait臈鈥� 2017鈥�2018 鈥� member of work group of the Ministry of Health, Republic of Lithuania, for revision of order Health care management of pregnant women, parturients and newborns;

Prof. D. Rama拧auskait臈鈥� 2017鈥�2018 鈥� member of work group of the Ministry of Health, Republic of Lithuania, for the project Provision of obstetrical daily in-patient services and payment of these services from the budget of the compulsory health insurance fund.

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

Prof. 沤. Bumbulien臈. LITEXPO 23-24 November 2018, exhibition 鈥濻chool 2018鈥�. Lecture Peculiarities and challenges of the adolescence period. Organizer: Ministry of Education and Science.

Asist. D. Bu啪inskien臈. Publication in Endometriosis, its causes, prevalence, progress, diagnostic and treatment tactics. December 2018.

Prof. Nijol臈 Drazdien臈. Prevention of premature newborns respiratory syncope virus infection. Recommendations for Prevention of Premature Newborns Respiratory Syncytial Virus Infection for Parents, p. 15. Vilnius.

Publication in : Assoc. prof. D. Lau啪ikien臈, 2018-08-30 Carrying and delivering a baby was never easy; August 30, Ovarian cancer; Assoc. prof. A. Arlauskien臈, March 30, Possibilities of fetal surgery.

Prof. D. Rama拧auskait臈. Article 鈥淰aginal dryness鈥� Lietuvos sveikata (journal Lithuanian Health), March 08.

CLINIC OF ANAESTHESIOLOGY AND REANIMATOLOGY

2 Santari拧ki懦, LT-08661, Vilnius
Tel. 236 5235
E-mail:

Head 鈥� Prof. Dr. J奴rat臈艩ipylait臈

STAFF

Professors: Dr. J. 艩ipylait臈, Dr. S. Vosylius,
Senior researcher: Dr. A. Andrijauskas.
Associate professors: Dr. E. Kontrimavi膷i奴t臈, Dr. M. 艩erpytis, Dr. D. 膶in膷ikas, Dr. A. Klima拧auskas, Dr. I. Norkien臈.
Assistant professors: Dr. S. 艩vedien臈, Dr. R. Badaras (part-time), Dr. D. Ringaitien臈 (part-time),
Lecturers: A. Vaitkus (part-time), E. Gai啪auskas (part-time), 艩. Judickas (part-time), V. Kuzminskait臈 (part-time), L. Bal膷i奴nas (part-time), D. 艩ileikis (part-time).
Doctoral students: A. Vaitkus, M. Svetikien臈, 艩. Judickas, D. Gai啪auskait臈.
Students鈥� scientific group of Anaesthesiology and Reanimatology: scientific leader 鈥� Prof. S. Vosylius, coordinator 鈥� student G. Sakalauskait臈, 39 members of the group.

RESEARCH INTERESTS

Etiopathogenesis, diagnostics, treatment of diseases: fundamental and clinical research, innovative technologies
Influence of malnutrition on rate of complications and duration of hospital stay in patients after cardiac surgery
Optimization of low back pain diagnosis and treatment
Early changes in cognitive functioning in patients undergoing general anesthesia
Optimal cerebral perfusion pressure target treatment for traumatic brain injury patients

RESEARCH PROJECTS CARRIED OUT IN 2018

Project Supported by University Budget

Perioperative Patient Optimization and Management of Critical States. Prof. Dr. J. 艩ipylait臈. 2014鈥�2018.

Retrospective analysis of prospectively gathered data in scietific study The relationship between malnutrition, rate of complications and duration of hospital stay in patients after cardiac surgery was perfomed. In order to determine the relationship between the pre-operative bioelectric impedance phase angle (malnutrition criteria) and late mortality and blood transfusions after cardiac surgery. The effect of blood transfusions during the perioperative period on late mortality was also studied.

Main publications:

Ringaitiene, D, Puodziukaite, L, Vicka, V, Gineityte, D, Serpytis, M, Sipylaite, J. 2018. Bioelectrical impedance phase angle-predictor of blood transfusion in cardiac surgery. Journal of Cardiothoracic and Vascular Anesthesia, first on line, p. 1鈥�7, doi: 10.1053/j.jvca.2018.07.007.

Petkus, V., Preiksaitis, A., Krakauskaite, S., Bartusis, L., Chomskis, R., Hamarat, Y., Zubaviciute, E., Vosylius, S., Rocka, S., Ragauskas, A. 2018. Non-invasive cerebrovascular autoregulation assessment using the volumetric pressure reactivity index: prospective study. Neurocritical Care, vol. 30(1), p. 42鈥�50, p. 1鈥�9,

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Research and Education, Department of Clinical Science and Education, Karolinska Institutet/S枚dersjukhuset Section of Anaesthesiology and Intensive Care (Sweden).

OTHER SCIENTIFIC ACTIVITIES

Prof. J. 艩ipylait臈 鈥�

counsil member of Lithuanian Society of of Anaesthesiology and Intensive Care,
member of the European Society of Anaesthesiology,
member of the Board of Anaesthesiology of Medical Specialists of the European Union,
editorial board member of the journal Acta medica Lituanica,
chairman of Committee of Medical Studies Programme Vilniaus University Faculty of Medicine (until June), .

Prof. S. Vosylius 鈥�

council member of Lithuanian Society of of Anaesthesiology and Intensive Care,
member of the European Society of Intensive Care Medicine,
editorial board member of the Journal Lietuvos chirurgija,
member of Vilnius Regional Biomedical Ethics Committee,

Senior researcher A. Andrijauskas 鈥�

member of the Lithuanian Society of Anaesthesiology and Intensive Care,
member of the European Society of Anaesthesiology,
member of Western Anaesthesia Society of Ireland.

Assoc. Prof. M. 艩erpytis 鈥�

treasurer of the Lithuanian Society of Anaesthesiology and Intensive Care, .

Assoc. Prof. I. Norkien臈 鈥�

member of the Lithuanian Society of Anaesthesiology and Intensive Care,
member of the European Society of Anaesthesiology,
Representative Council member of European Association of Cardiothoracic Anaesthesiology,

Assoc. Prof. D. 膶in膷ikas, Assoc. Prof. E. Kontrimavi膷i奴t臈 鈥�

members of the Lithuanian Society of Anaesthesiology and Intensive Care, .

Assoc. Prof. A. Klima拧auskas 鈥�

vicepresident of the Lithuanian Society for Parenteral and Enteral Nutrition, www.lpemd.org;
council member of the Lithuanian Society of Anaesthesiology and Intensive Care, .

Assist. Prof. S. 艩vedien臈 鈥�

member of Lithuanian Society of Anaesthesiology and Intensive Care,
ESRA member and Baltic ESRA Counsil member,

Asisst. Prof. D. Ringaitien臈 鈥�

member of congress committee of the 9th International Baltic Congress of Anaesthesiology, Intensive Care and Pain Management,
member of Lithuanian Society of Anaesthesiology and Intensive Care,
member of European Society of Intensive Care Medicine,
member of European Society for Clinical Nutrition and Metabolism, .

Lect. 艩. Judickas, Lect. E. Gai啪auskas, lect. L. Bal膷i奴nas 鈥�

members of the Lithuanian Society of Anaesthesiology and Intensive Care,
members of European Society of Intensive Care Medicine, .

CLINIC OF EAR, NOSE, THROAT AND EYE DISEASES

2 Santari拧ki懦, LT-08661 Vilnius
Tel.: 236 52 70, 250 1867
E-mail:

Head 鈥� Prof. Dr. Eugenijus Lesinskas

STAFF

Professor: Dr. E. Lesinskas.
Associate profesors: Dr. M. Petrulionis, Dr. R. A拧oklis, Dr. A. Cimbalas, Dr. S. Galgauskas.
Assistants: Dr. D. Auk拧tikalnis, Dr. V. Bele拧kien臈, Dr. D. Rauba, Dr. J. Iva拧ka.
Lecturers: A. Morozas, A. Matulevi膷ius, K. Maly拧ko.
Students鈥� scientific groups of:
Ophtolmology: scientific leader 鈥� assoc. prof. S. Galgauskas, coordinator 鈥� student A. Rak拧tyt臈; 61 members of the group.
Otorhinolaryngology: scientific leader 鈥� prof. E. Lesinskas, coordinator 鈥� student R. Kernagyt臈; 20 members of the group.

RESEARCH INTERESTS

Estimation of the influence of morphology and clinical peculiarities of otorhinolaryngological and ophtalmological diseases to results of application of novel diagnostic methods and treatment

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Influence of Morphology and Clinical Peculiarities of Otorhinolaryngological and Ophtalmological Diseases to Results of Application of Novel Diagnostic Methods and Treatment. Prof. E. Lesinskas. 2014鈥�2018.

Clinical assessment and evaluation of the functional results developing of etiologic profile. Cochlear implantation for children, analysis of radiologic, genetic, systemic prognostic factors. Evaluation of peripheral vestibular system in diagnostic and treatment of Meniere鈥檚 disease: correlation of the data of videonystagmometry, posturography and temporal bone radiology, analysis of the results.

Ocular posterior pole changes in glaucomatous eyes. Prevalence of retinal dystrophies and degenerations in Lithuania. Evaluation of intraocular pressure, choroidal and retinal thickness measurements using optical coherence tomography in non-diabetic haemodialysis patients. Evaluation of lamina cribrosa changes in glaucoma patients. Choroidal thickness mesurements in diabetic patients with macular edema treated with VEGF innhibitors. Correlation of macular degeneration autofluorescence findings with functional impairment. The use of autofluorescence findings for differential diagnosis of uveal melanomas. Evaluation of the anterior chamber changes after laser iridotomies by optical coherence tomography and the retinal nerve fiber layer thickness and its relation to visual evoked potentials in multiple sclerosis.

Main publication:

Kadziauskien臈, A., Ja拧inskien臈, E., A拧oklis, R., Lesinskas, E., Reka拧ius, T., Chua, J., Cheng, C.Y., Mari, J.M., Girard, M.J.A., Schmetterer, L. 2018. Long-term shape, curvature, and depth changes of the Lamina Cribrosa after trabeculectomy. Ophthalmology, vol. 125, no. 11, p. 1729鈥�1740, doi: 10.1016/j.ophtha.2018.05.011.

National Research Projects

Social Integration Challenges of Children with Cochlear Implants in Lithuania. Prof. E. Lesinskas.

The main goal of this project is to evaluate macro- and micro-level determinants of social integration of children with cochlear implants in Lithuania. As the result of this study recommendations for the social integration program of children with cochlear implants are being prepared. Methods of sociology, social policy and public health are used in this project. The social integration problems of children with cochlear implants is being analysed by using bio-psycho-social theoretical approach and combining different research methods. These new and comprehensive findings of interdisciplinary project expand scientific knowledge of social and health sciences. Furthermore the results of the projects will create preconditions to optimize social integration of children with hearing loss. The empirical part of the project is based on few databases: public health statistics, health policy documents and legislation, children鈥檚 with cochlear implants audiological research data, survey and semi-structured interview data.

OTHER SCIENTIFIC ACTIVITIES

Prof. E. Lesinskas 鈥�

senior otorhynolaryngologist of the Ministry of Health Care of the Republic of Lithuania;
president of the Lithuanian Society of Otorhinolaryngologists;
member of the Council of the Faculty of Medicine;
editorial board member of the journals Medicinos teorija ir praktika (Theory and Practice in Medicine), Journal of Hearing Science.

Assoc. Prof. Dr. R. A拧oklis 鈥�

board member of Lithuanian Society of Ophthalmologists;
board member of Vilnius County Ophthalmologists Association;
member of European Board of Ophthalmology;
national delegate in European Union of Medical Specialists.

Assoc. Prof. Dr. A. Cimbalas 鈥�

board member of Lithuanian Society of Ophthalmologists;
board member of Vilnius County Ophthalmologists Association;
member of Lithuanian Glaucoma Society;
international member of American Academy of Ophthalmology.

Assoc. Prof. Dr. S. Galgauskas 鈥�

board member of Vilnius County Ophthalmologists Association;
member of Lithuanian Society of Ophthalmologists;
member of Lithuanian Glaucoma Society;
member of European Association for Vision and Eye Research;
member of Association for Research in Vision and Ophthalmology.

Assist. Dr. D. Rauba 鈥�

board member of Lithuanian Society of Otorhinolaryngologists.

CLINIC OF GASTROENTEROLOGY, NEPHROUROLOGY AND SURGERY

2 Santari拧ki懦, LT-08661 Vilnius
Tel. 236 5250
E-mail:

Head 鈥� Prof. Habil. Dr. K臋stutis Strupas

STAFF

Professors: Habil. Dr. K. Strupas, Dr. V. Bei拧a, Dr. E. Po拧kus, Dr. T. Po拧kus, Dr. G. Simutis, Dr. A. 艩ileikis, Dr. G. Brimas, Dr. F. Jankevi膷ius, Dr. M. Miglinas, Habil. Dr. J. Valantinas.
Associate professor: Dr. V. Jotautas, Dr. V. Sokolovas, Dr. K. Saniukas, Dr. G. Verkauskas, Dr. A. 沤elvys, Dr. A. 膶erniauskien臈, Dr. G. Denapien臈, Dr. A. Sta拧inskas,. Dr. S. Mikalauskas, Dr. H. Ramonas (till September 2018).
Assistant professor: Dr. E. Gavelien臈, Dr. R. Adomaitis, A. 膶ekauskas, Dr. A. Gradauskas, D. Kubilius, Dr. I. Savlan, Dr. 沤. Juodeikis, Dr. K. Trainavi膷ius, Dr. I. Stundien臈, Dr. L. Rim拧evi膷ius.
Teaching assistants: B. Buckus, A. Bakavi膷ius, E. Ma膷ionien臈.
Lecturers: P. Gradauskas, G. Po拧i奴nas, Dr. L. Ma拧alait臈, R. Vaicekauskas.
Research fellows: Dr. V. Liakina, M. Petrulionis
Doctoral students: B. Buckus, A. Rybakovas, A. Mickevi膷ius, E. Ma膷ionien臈, M. Barisien臈, A. Bakavi膷ius, J. Tumas, D. Danys, A. Aleknait臈, J. Makevi膷ius, G. Tauginien臈鈥� Valeikait臈, B. Vincel, Aist臈 Gulla, B. Kurlinkus, R. Vaicekauskas, D. Sukackien臈, P. Bosas, R. Bau拧ys, R. Luk拧ait臈, R. Ra膷kauskas, M. Kry啪auskas, V. Kazlauskasa, M. Snicorius.

RESEARCH INTERESTS

Minimally invasive surgery of abdominal organs, development and improvement of new procedures and devices for the performance of minimally invasive procedures, especially of abdominal malignancies
Research of liver and pancreas transplantation techniques (listing and preparing of patients for liver, pancreas, kidney transplantation)
Research of liver and pancreas transplantation techniques
Study of dietary treatment of enteropathies
Minimal hepatic encephalopathy
Diagnostic/prognostic markers for prediction of HCC
Novel treatment for the GI bleeding
Contemporary diagnostic analysis of ascite liquid
Epidemiology and novel treatment of viral hepatitis
Patients with chronic hepatitis C quality of life study during DAA therapy
Urological cancer
Kidney stone disease
Urinary incontinence

Primary glomerular diseases
Resistant hypertension
Peritoneal dialysis
Medical kidney transplant management

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Investigation Efficiency of Traumatic鈥揜estorative, Minimally Invasive Surgeries and Transplantation Methods in Visceral Surgery. Prof. K. Strupas, Prof. G. Brimas. 2014鈥�2018.

Possibilities and results of minimally invasive surgery in patients with liver, adrenal gland, thyroid and parathyroid glands, pancreas and colorectal pathology were collected and evaluated. Results of the research were presented in international meetings. The successful organ-tissues transplantations-program in 91桃色 Hospital Santaros klinikos is the best fact to make 91桃色 Hospital the leader Transplantation Center in the Baltic States.

Influence of Pancreatic and Periampullary Cancer, Immunomodulation and Surgery on Patient Metabolism and Treatment Outcomes. Prof. A. 艩ileikis, Prof. K. Strupas, J. Tumas. 2016鈥�2019.

Research was started in 2016, the time schedule for our research is 2016鈥�2019, number of subjects is 95. The research focuses on effects of pancreatic cancer and immunonutrition on the metabolism and immune system and the use of metabolomic analyses for stratification of patients for nutritional management with the aim to improve postoperative outcomes. Amino acids comprise a small, but significant part of metabolome. Amino acid analyses improve evaluation of nutritional status and treatment of malnutrition in cancer. Besides, these analyses can be of high importance for metabolic cancer phenotyping, differential diagnostics and prognostication. We introduced supplementary radiological methods for lumbar skeletal muscle index measurements, bioelectrical impedance analysis in our patients for better evaluation of nutritional status.

The prospective clinical study. BRAFV600E Mutation and Other Molecular Markers for Diagnosis of Thyroid Malignancies. Prof. V. Bei拧a, Dr. A. Bei拧a. 2018.

The research was ended in June 2018. This clinical study contained the data collected of 288 patients. Unique PTC risc calculator based on the BRAF V600 mutation testing combined with the analysis of the cytomorphological features was created. An online version of the calculator for clinical applications was deweloped and can be found at In total, three papers were published in journals indexed by Clarivate Analytics Web of Science, the data was presented at eight international conferences, and the dissertation entitled The significance of the BRAF V600E mutation and the cytomorphological features for the optimization of papillary thyroid cancer diagnostics was deffended.

Main publication:

Bei拧a, A., Kvietkauskas, M., Bei拧a, V., Sto拧kus, M., Ostanevi膷i奴t臈, E., Jasi奴nas, E., Gri拧kevi膷ius, L., 艩einin, D., 艩ileikyt臈, A., Strupas, K. 2018. Significance of BRAF V600E mutation and cytomorphological features for the optimization of papillary thyroid cancer diagnostics in cytologically indeterminate thyroid nodules. Experimental and Clinical Endocrinology & Diabetes, 1鈥�8, doi: 10.1055/a-0588-4885.

The Role of Intraoperative Neurostimulation with Laryngeal Palpation and Intraoperative Laryngeal Ultrasound in Optimizing the Safety of a Thyroidectomy. Prof. K. Strupas, A. Rybakovas, Prof. V. Bei拧a. 2014鈥�2018.

The study was finished in 2018. The objective of the prospective cohort study was to determine the reliability of LP and intraoperative LU methods for evaluating the RLN functional status during thyroid surgery

Main publications:

Rybakovas, A., Bausys, A., Matulevicius A., Zaldokas, G., Kvietkauskas, M., Tamulevicius, G., Beisa V., Strupas K. 2018. Recurrent laryngeal nerve injury assessment by intraoperative laryngeal ultrasonography: a prospective diagnostic test accuracy study. Wideochir Inne Tech Maloinwazyjne, vol. 14, no. 1, 38鈥�45, doi: 10.5114/wiitm.2018.80066.

Rybakovas, A., Matulevi膷ius, A., Belogorceva, V., Bei拧a, V., Strupas, K. 2018. Laringin臈 palpacija skydliauk臈s chirurgijoje: praktin臈s rekomendacijos, remiantis i拧samia literat奴ros ap啪valga ir perspektyviojo kohortinio tyrimo rezultatais (Laryngeal palpation in thyroid surgery: practical recommendations for method integration into daily clinical practice according to comprehensive literature review and prospective cohort study results). Lietuvos chirurgija, vol. 17, no 3-4, p. 238鈥�250, doi: 10.15388/LietChirur.2018.3-4.12048.

Choledocholithiasis Management Based on Individual Risk and Multidisciplinary Approach for Patients with Cholecystolithiasis and Scheduled Cholecystectomy. Prof. G. Simutis, A. Aleknaite. 2016鈥�2018.

Based on the results of retrospective study performed in 2017, a randomized prospective trial protocol on the best management strategy for patients before laparoscopic cholecystectomy with intermediate risk of choledocholithiasis was prepared. It was approved by Vilnius Regional Bioethics Committee. The trial protocol was registered at an international registry of clinical studies ClinicalTrials.gov (Identifier: NCT03658863). Patients for the randomized prospective trial are being recruited and managed according to the study protocol. The results of the study were presented at three scientific conferences.

Main publication:

Aleknaite, A., Simutis, G., Stanaitis, J., Valantinas, J., Strupas, K. 2018. Risk assessment of choledocholithiasis prior to laparoscopic cholecystectomy and its management options. United European Gastroenterology Journal, vol. 6, no 3, p. 428鈥�438, doi: 10.1177/2050640617731262.

Laser Hemorrhoidoplasty, Hemorrhoidopexy and Hemorrhoidectomy. D. Danys, Prof. T. Po拧kus. 2015鈥�2019.

Randomized prospective trial was finished, and analysis is being performed and publications prepared. The aim of the study is to compare early and one-year outcomes of two new surgical techniques of treatment of haemorrhoids with traditional excisional hemorrhoidectomy. The study is finished including patients, completed 6 weeks follow-up (early results), by including 120 patients. Initial results were presented at the World Congress of Phlebology in Melbourne, Australia, Korean Society of Coloproctology research meeting in Seoul, Korea, European Society of Coloproctology meeting in Nice, France.

Distant Results of the Quality of Life of Patients Operated on for Colorectal Cancer. G.Valeikaite Tauginiene, Prof. T. Po拧kus.

The Study was started in 2016. Distant results of the quality of life of patients, operated on for colorectal cancer is a continuation of the prospective study, which was started in 2012 as part of the National Science Foundation grant Colorectal cancer in Lithuania: study of mortality, morbidity and quality of life, LIG01/11. It will try to identify the factors, reducing long-term quality of life in colorectal cancer patients. The study is performed in collaboration with National Cancer Institute and Lithuanian University of Health Sciences. The patients, operated on with the curative intent for colorectal cancer are currently being followed-up 5 years after initial operation the final follow-up will be available by late December, 2017. Final publication is planned for 2019.

Main publications:

Jakubauskas, M., Jotautas, V., Poskus, E., Mikalauskas, S., Valeikaite-Tauginiene, G., Strupas, K., Poskus, T. 2018. Fecal incontinence after transanal endoscopic microsurgery. International Journal of Colorectal Disease, vol. 33, no., p. 467鈥�472, doi: 10.1007/s00384-018-2983-0.

Jakubauskas, M., Jotautas, V., Poskus, E., Mikalauskas, S., Valeikaite-Tauginiene G., Strupas K., Poskus, T. 2018. Management of colorectal anastomotic stricture with transanal endoscopic microsurgery (TEM). Techniques in Coloproctology, vol. 22, iss. 9, p. 727鈥�729, doi: 10.1007/s10151-018-1858-2.

Diagnosis of Acute Appendicitis.

The study was started in 2019. It is a randomized trial within prospective cohort of patients with suspected acute appendicitis, randomized for CT or observation in cases when ultrasound examination is inconclusive. 250 patients are set to be included in the trial. Inculsion is planned for two years. Publication of the results is expected in 2022.

The Value of Spectroscopy and Molecular Markers in Diagnosis and Prognosis of Urological Cancer. Prof. F. Jankevi膷ius. 2014鈥�2018.

The rates of PCa upgrading and upstaging were analyzed in 1056 PCa patients, where upgrading was observed in 27.2% and upstaging in 20.3% of patients. Combination of PSA with our 3-gene test (RARB, RASSF1, and GSTP1) in urine was predictive for PCa upstaging and upgrading, so resulted in an accurate predicting model.A novel technique to analyze air-dried kidney tissue impression smears by means of attenuated total reflection infrared (ATR-IR) spectroscopy was developed. Combination of this method with optical fiber ATR probes may be already transformed to the clinics for rapid real-time intra-operative tissue analysis. Accuracy of classification is 92% for the normal tissues and 94% for the cancerous ones.

Main publication:

Pucetaite, M., Velicka, M., Urboniene, V., Ceponkus, J., Bandzeviciute, R., Jankevicius, F., Zelvys, A., Sablinskas, V., Steiner, G. 2018. Rapid intra-operative diagnosis of kidney cancer by attenuated total reflection infrared spectroscopy of tissue smears. Journal of Biophotonics, vol. 11, iss. 5, art. no. e201700260, [23], doi: 10.1002/jbio.

The Value of Clinical and Molecular Markers in Preoperative Diagnosis of Prostate Cancer. A. Bakavi膷ius, Prof. F. Jankevi膷ius.

The study was started in 2015. In total, 1056 patients included in the study entitled The value of clinical and molecular markers in preoperative diagnosis of prostate cancer with 514 urine samples available for molecular analysis. During 2018, the data of the study was presented at conferences: The COINS 2018; 28 February, 2018, Vilnius, Lithuania; 15^th International Conference of the Lithuanian Biochemical Society, June 26, 2018, Dubingiai, Lithuania; 5^th EAU Baltic meeting 2018, May 25, 2018, Riga, Latvia; and 38th Congress of the Soci茅t茅 Internationale d'Urologie (SIU), October, 2018, Seoul, Korea.

Pathogenetic Relationships of Chronic Liver Disease with Disorders of Other Abdominal Organs, Improvement of Therapeutic and Surgical Treatment. Prof. J. Valantinas. 2014鈥�2018.

We have found that UCKL-1 expression in combination with IL28B rs8099917 TT and rs12979860 CC SNPs is strongly associated with increased chances of hepatocellular carcinoma (HCC) development in HCV-positive cirrhotic patients. The presence of rs8099917 TT single-nucleotide polymorphism (SNP) elevated the chances of HCC manifestation more than sevenfold (OR=7.3, p=0.0273). The presence of rs12979860 CC SNP also heightened HCC chances more than sevenfold (OR=7.5, p=0.0765). Moreover, in the HCC group, a combination of IL28B rs12979860 non-TT and rs8099917 TT genotypes was observed more often, compared with the non-HCC group. Other combinations of IL28B rs12979860 and rs8099917 SNIPs were associated with a reduced risk of HCC development, approximately at the same extent.

Main publication:

Buivydiene, A., Liakina, V., Kashuba, E., Norkuniene, J., Jokubauskiene, S., Gineikiene, E., Valantinas, J. 2018. Impact of the uridine cytidine kinase like-1 protein and IL28B rs12979860 and rs8099917 SNPs on the development of hepatocellular carcinoma in cirrhotic chronic hepatitis C patients - a pilot study. Medicina, vol. 54, iss. 5, doi: 10.3390/medicina54050067.

National Research Projects

Research project New Multifunctional Nanobiosensor for Early Pancreatic Cancer Diagnostics, (SEN-16041), started in 2016, is a consistent continuity of previous project, entitled Identification of early diagnostic and prognostic biomarkers of pancreatic intraductal adenocarcinoma using protein mass spectrometry analysis.

Project leader: Prof. K. Strupas. Project group: Prof. A. 艩ileikis, M. Valius, A. Kaupinis, M. Ger, M. Petrulionis, B. Kurlinkus.

In 2018, the biobank was extended up to 175 samples of histological material, 112 samples of blood serum and more than 50 samples of urine. Additional deep proteomic analysis of 20 samples was performed. Totally 9 potencial pancreatic cancer biomarkers were identified in tumor tissues. Evaluation of 2 years patients鈥� survival has identified prognostic value of FLT3 and PCBP3 after radical surgery for pancreatic cancer. Prototype system for concentration and visualisation of biomarkers was created. With this system presence of CEACAM6 marker was confirmed in blood serum. 1 manuscript was published (web of science), 4 presentations were presented at international conferences.

Main publication:

Ger, M., Kaupinis, A., Petrulionis, M., Kurlinkus, B., Cicenas, J., Sileikis, A., Valius, M., Strupas, K. 2018. Proteomic identification of FLT3 and PCBP3 as potential prognostic biomarkers for cancreatic Cancer. Anticancer Research, vol. 38, iss. 10, p. 5759鈥�5765, doi: 10.21873/anticanres.12914.

Non-Invasive Approach to Early Diagnosis and Prognosis of Acute Severe Pancreatitis. (01.2.2-LMT-K-718-01-0025). Project leader: J. Razumien臈. Project group: Prof. K. Strupas; Prof. A. 艩ileikis; Assoc. Prof. D.V itkus; Assoc. Prof. M. 艩erpytis, Assoc. Prof. A. Klima拧auskas, A. Karpavi膷ius; A. Samuilis; A. Kielait臈-Gulla; R. Budvytyt臈; T. Ragaliauskas; M. Jankunec; T. Penkauskas; I. 艩akinyt臈; M. Dagys; A. Lauryn臈nas; V. Gurevi膷ien臈; D. Ratautas.

The project started in January 2018. The biomedical ethics approval was received and clinical database was initiated of acute pancreatitis. We started our first experiments with construction and characterization of immobilized membranes on the surface. The use of the effect of dielectric damage of membranes by the EIS, will also be applied for investigation of specific proteins (HSP and CRP) in acute pancreatitis disease. In order to use these proteins as biomarkers for the development of non-invasive methods for acute pancreatitis diagnosis;

Parallel design and optimization of non-invasive sensors for detection of urea, glucose, creatinine, bilirubine, cortisol and calcium ions was initiated. Creation of electrochemical sensor for lipase activity assessment. Performing of tasks on sensors surfaces functionalisation and selectivity achievement.

Patent application (investigators: Prof. K. Strupas, PhD candidate A. Gulla) Non-invasive approach to early diagnosis and prognosis of acute severe pancreatitis based on heat shock proteins mechanism of action.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

University of Heidelberg (Germany)
Renal Services at Westmead Hospital, Sydney (Australia)
Academy of Science of Ukraine (Ukraine)
Karolinska Institute (Sweden)
University of Warsaw (Poland)
University of Latvia (Latvia)
University of Tallinn (Estonia)

OTHER SCIENTIFIC ACTIVITIES

Prof. Habil. Dr. K. Strupas 鈥�

past President of Lithuanian Surgical Oncology society;
board member of the European Academy of Surgical Scienses (EAcSS);
member of International Hepato-Pancreato-Biliary Association;
member of the Scientific Committee of 91桃色;
elected president of the Association of Lithuanian Surgeons;
member of European Association for Endoscopic Surgery (EAES);
editorial board member of the international journal Viszeralmedizin,
editorial board member of the journal Medicinos teorija ir praktika (Theory and Practice in Medicine),
editorial board member of the journal Lietuvos chirurgija (Lithuanian Surgery)
editorial board member of the journal Medicina (Lithuania, ISI),

Prof. Dr. V. Bei拧a 鈥�

chairman of Vilnius Association of Surgeons;
member of the European Society of Endocrine Surgeons (ESES);
member of the International Society of Surgery (ISS).

Prof. G. Simutis 鈥�

board member of the Lithuanian Minimally Invasive Surgery Society;
member of Vilnius Association of Surgeons;
member of Lithuanian Surgical Oncology society;
member of European Association for Endoscopic Surgery (EAES).

Prof. E. Po拧kus 鈥�

chairman of the Lithuanian Minimally Invasive Surgery Society;
member of Lithuanian Surgical Oncology society;
member of the Lithuanian Society of Coloproctologists;
member of the European Society of Coloproctology;
member of the International Society of University Colon and Rectal Surgeons;
member of European Association for Endoscopic Surgery (EAES).

Prof. A. 艩ileikis 鈥�

chairman of Vilnius Association of Surgeons;
chairman of Lithuanian Surgical Oncology society;
member of the International HepatoPancreato Biliary Association (IHPB);
member of the American Society of Clinical Oncology (ASCO);
member of the Lithuanian Minimally Invasive Surgery Society.

Prof. T. Po拧kus 鈥�

Vice-president of the Lithuanian Society of Coloproctologists;
member of Lithuanian Surgical Oncology society;
member of Vilnius Association of Surgeons.

Assoc. Prof. Dr. V. Sokolovas 鈥�

president Lithuanian Association of Transplantology;
member of the Lithuanian Minimally Invasive Surgery Society;
member of Vilnius Association of Surgeons;
member of Lithuanian Surgical Oncology Society;
member of the Lithuanian Enteral and Parenteral Nutrition Society;
member of the Lithuanian Society of Gastroenterology.

Assoc. Prof. Dr. V. Jotautas 鈥�

member of the Lithuanian Minimally Invasive Surgery Society;
member of Vilnius Association of Surgeons;
member of the Lithuanian Society of Coloproctologists;
member of European Association for Endoscopic Surgery (EAES).

Assoc. Prof. S. Mikalauskas-

board member of the Lithuanian Minimally Invasive Surgery Society;
member of Vilnius Association of Surgeons;
member of the Lithuanian Society of Coloproctologists;
member of European Association for Endoscopic Surgery (EAES);
member of Lithuanian Surgical Oncology Society.

Prof. Habil. Dr. J. Valantinas 鈥�

editor of the journal Internistas supplement Gastroenterology;
editorial board member of the journal World Journal of Gastroenterology;
editor board member of the journal Medicinos teorija ir praktika;
member of the international Pancreas-2000 scientists group;
member of the European Association for the Study of the Liver (EASL);
member of the World Organization of Gastroenterology (OMGE);
president of the Lithuanian Society of Gastroenterology.

Assoc. Prof. E. Gavelien臈 鈥�

member of the Lithuanian Society of Gastroenterology;
member of the European Association of Enteral and Parenteral Nutrition.

Assoc. Prof. G. Denapien臈, Assistant Prof. I. Stundien臈, Lect. L. Ma拧alait臈, Assist. Prof. I. Savlan, Lect. R. Vaicekauskas 鈥�

members of the Lithuanian Society of Gastroenterology.

Research Prof. V. Liakina 鈥�

member of the European Association for the Study of the Liver (EASL);
member of the Lithuanian Society of Gastroenterology;
member of the Lithuanian Society of Immunology.

Prof. Dr. G. Brimas 鈥�

deputy editor-in-Chief of the journal Lietuvos chirurgija;
editorial board member of the journal Videosurgery and miniinvasive techniques.

Assoc. Prof. A. Sta拧inskas 鈥�

editorial board member of the journal Lietuvos chirurgija;
board number of the Association of Lithuanian Surgeons.

Teach. Assist. B. Buckus 鈥�

member of Vilnius Society of Surgeons.

Assoc. Prof. K. Saniukas 鈥�

president of the Baltic Spinal Cord Injury Scientific Society;
president of Lithuanian Scientific Society of Paediatric Orthopaedics and Traumatology.

Assist. Prof. K. Trainavi膷ius 鈥�

member of the Baltic Association of Pediatric Surgeons (BAOPS);
member of the Council of Lithuanian Society of Pediatric Surgery;
editorial board member of the journal Pediatrija (Paediatrics), ;
member of the European Paediatric Surgeons Association.

Assoc. Prof. G. Verkauskas鈥�

member of the European Paediatric Surgeons鈥� Association;
member of the European Society for Paediatric Urology.

Prof. Dr. F. Jankevi膷ius 鈥�

chairman of the Lithuanian Early Prostate Cancer Detection Programme;
member of the European Association of Urology (EAU);
corresponding Memebr of Deutschen Gesellschaft fur Urologie;
member of Lithuanian Urological Association;
chairman of Lithuanian Society of Oncologists.

Assoc. Prof. A. 沤elvys 鈥�

member of the Lithuanian Urology (LUD) Society;
member of the European Association of Urology (EAU);
member of the Lithuanian Nephrology Dialysis Transplantation Association (LNDTA);
member of the Lithuanian Society for Sexual Medicine (LSSM).

Assoc. Prof. A. 膶erniauskien臈 鈥�

member of the Lithuanian Urology (LUD) Society;
member of the Lithuanian Society for Sexual Medicine (LSSM).

Assist. Prof. A. 膶ekauskas 鈥�

member of the Lithuanian Urology (LUD) Society;
member of the Lithuanian Nephrology Dialysis Transplantation Association (LNDTA);
member of th European Association of Urology (EAU).

Assist. Prof. R. Adomaitis 鈥�

member of the Lithuanian Urology (LUD) Society;
member of the Lithuanian Society for Sexual Medicine (LSSM);
member of the European Society for Sexual Medicine (LSSM).

Teach. Assist. A. Bakavi膷ius 鈥�

member of the Lithuanian Urology (LUD) Society;
member of th European Association of Urology (EAU).

Prof. M. Miglinas 鈥�

member of the European Dialysis Transplanatation Association 鈥� European Renal Association(EDTA-ERA);
member of the European Society of Hypertension (ESH);
member of the International Society of Nephrology (ISN);
member of the International Society of Hypertension (ISH);
president of Lithuanian Kidney Foundation;
president of the Lithuanian Hypertension Society.

Assist. Prof. L. Rim拧evi膷ius 鈥�

member of the European Dialysis Transplanatation Association 鈥� European Renal Association (EDTA-ERA);
member of Lithuanian Nephrology, Dialysis and Transplantation Association (LNDTA);
member of Lithuanian Kidney Foundation (LKF).

Teach. Assist. Prof. E. Ma膷ionien臈 鈥�

member of the European Dialysis Transplanatation Association 鈥� European Renal Association (EDTA-ERA);
member of Lithuanian Nephrology, Dialysis and Transplantation Association (LNDTA);
member of Lithuanian Kidney Foundation (LKF).

MOST IMPORTANT NATIONAL AND INTERNATIONAL AWARDS RECEIVED FOR R&D ACTIVITIES

Prof. Habil. Dr. K臋stutis Strupas. 91桃色 Rector鈥檚 Research award.

Prof. Dr. Feliksas Jankevicius for his research on new generation of cancer markers was awarded with medal of SAPIENTI SAT of the J臋drzej 艢niadecki, Karol Olszewski and Zygmunt Wr贸blewski Association.

Prof. M. Miglinas. Cross of the Knight of the Order of the Lithuanian Grand Duke Gediminas.

MOST IMPORTANT PARTICIPATION CASES OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

L. Rim拧evi膷ius. Peritoneal dialysis reimbursement, working group (State Patient Fund).

L. Rim拧evi膷ius. Predialysis education, educational seminars (National Patients鈥� Organization 鈥楪yvastis鈥�).

Prof. A. 艩ileikis. Member of the Health Care Council of Vilnius City Municipality.

CONSULTATIONS PROVIDED BY THE UNIT TO THE PUBLIC OR ECONOMIC ENTITIES

Consultations to R&D and Innovation Priority Execution Working Group of Ministry of Economy have been provided by prof. Feliksas Jankevi膷ius.

Laurynas Rim拧evi膷ius. Consultation on kidney health. TV project.

Laurynas Rim拧evi膷ius. Painkillers and kidneys. TV project.

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

Feliksas Jankevi膷ius. To raise the awareness of science and its role in the evelopment of the society, four guided tours in VU Life Science Centre and National Cancer Centre were conducted in 2018 for students of Vilnius 沤irm奴n懦 gymnasium.

Laurynas Rim拧evi膷ius. Renal replacement therapy modalities. Popularisation in national wide media.
Prof. K. Strupas, Aiste Kielaite-Gulla. Signed Academic Excellence Exchange agreement with Kansai Medical University, Osaka, Japan.

CLINIC OF INFECTIOUS DISEASES AND DERMATOVENEREOLOGY

1 Birut臈s, LT-08117 Vilnius
Tel. 272 4657
E-mail: ;

Head 鈥� Prof. Dr. Ligita Jan膷orien臈

Centre of Infectious Diseases

1 Birut臈s, LT-08117 Vilnius
Tel: 272 4657
E-mail: ;

Head 鈥� Prof. Dr. Ligita Jan膷orien臈

Centre of Dermatovenereology

2 J. Kairi奴k拧膷io, LT-08411 Vilnius
Tel. 272 0385
E-mail:

Head 鈥� Dr. J奴rat臈 Grigaitien臈

STAFF

Professors: Dr. L. Jan膷orien臈 (part-time), Dr. R. Matulionyt臈, Habil. Dr. A. Ambrozaitis (part-time), Dr. M. Bylait臈-Bu膷inskien臈 (part-time).
Associate professor: Dr. R. Gancevi膷ien臈 (part-time).
Assistants: Dr. J. Grigaitien臈 (part-time), Dr. D. Radzi拧auskien臈 (part-time), B. Zablockien臈 (part-time).
Lecturers: A. Marcinkut臈 (part-time), E. Matulyt臈 (part-time), K. 沤virblyt臈 Skrebut臈nien臈 (part-time), T. Karmazien臈 (part-time), I. Kisielien臈 (part-time), T. Raudonis (part-time).
Research fellow: A. Stikleryt臈.
Doctoral students: R. Jur膷iukonyt臈, B. Zablockien臈, E. Matulyt臈, I. Kisielien臈.
Sudents鈥� scientific groups of:
Infectious diseases: scientific leader 鈥� Prof. L. Jan膷orien臈, coordinator 鈥� student R. Vaikutyt臈; 38 members of the group.
Dermatovenerology: scientific leader 鈥� Assoc. Prof. R. Gancevi膷ien臈, coordinator 鈥� student A. Timinskait臈; 58 members of the group.

RESEARCH INTERESTS

Pathogenesis, diagnostics, treatment and prevention of infectious diseases: assessment of the current diagnostics, treatment and prevention methods; search of a new diagnostics, treatment and prevention methods; study of the mechanisms of infectious diseases pathogenesis; study of a safety and efficacy of a new vaccines and drugs for the treatment and prevention of infectious diseases.

Effectiveness, feasibility and impact of latent tuberculosis treatment for the prevention of active tuberculosis among HIV-positive individuals

Incidence, etiology and pathogenesis of inflammatory chronic dermatosis (acne, rosacea, psoriasis, dermatitis, eczema, vitiligo): basic and clinical research, implementation of innovative technologies.

Dermatooncology in Lithuania: epidemiology, pathogenesis, diagnostics, treatment and prevention of epithelial skin cancers and melanoma.

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Pathogenesis, Diagnostics, Treatment and Prevention of Infectious Diseases. Prof. A. Ambrozaitis, Prof. L. Jan膷orien臈, Prof. R. Matulionyt臈, Prof. K. 沤agminas, Dr. D. Radzi拧auskien臈, B. Zablockien臈, A. Marcinkut臈, A. Stikleryt臈. 2014鈥�2018.

Tick-borne encephalitis in Lithuania in 2005鈥�2018: epidemiology and clinical features. The aim of this retrospective study was to describe the epidemiological patterns and clinical features of tick-borne encephalitis (TBE) in Lithuania during 2005鈥�2014. The retrospective study included 712 patients hospitalized with TBE in Vilnius district. Study will be continued adding data from the years 2018.

Main publication:

Radzi拧auskien臈 D., 沤agminas K., A拧oklien臈 L., Jasionis A., Mameni拧kien臈 R., Ambrozaitis A., Jan膷orien臈 L., Jatu啪is D., Petraityt臈 I., Mockien臈 E. 2018. Epidemiological patterns of tick-borne encephalitis in Lithuania and clinical features in adults in the light of the high incidence in recent years: a retrospective study. European Journal of Neurology, vol. 25, iss. 2, p. 268鈥�274, doi: 10.1111/ene.13486.

Prevalence of Viral Hepatitis A, B and C Serological Markers in the First Time Non-Remunerated Blood Donor鈥檚 Population in Lithuania. 2012鈥�2019.

The objective of this cross-sectional study was to estimate the prevalence viral hepatitis serologic and virologic markers, such as anti-HAV, HBsAg, HBV-DNR, anti-HBc, anti-HBs, anti-HCV, HCV-RNA among the first-time non-remunerated blood donors in Lithuania. The study is in progress.

Prevention of Influenza Viral Pneumonia Using Zanamivir and Antisense Oligonucleotide against Inducible Nitric Oxide Synthase. 2013鈥�2019.

The aim of the study was to evaluate how zanamivir and iNOS antisense suppress the pulmonary inflammation during influenza infection using mouse model. The weight variations and means of lung histologic scores were compared between the mouse groups. The levels of iNOS RNR, IFN-纬, TNF-伪 and influenza virus were determined using reverse transcriptase - polymerase chain reaction.

Main publication:

Zablockien臈 B., Ka膷ergius T., Ambrozaitis A., 沤urauskas E., Bratchikov M., Jurgauskien臈 L., Zablockis R., Gravenstein S. 2018. Zanamivir diminishes lung damage in influenza A virus-infected mice by inhibiting nitric oxide production. In Vivo, vol. 32, iss. 3, p. 473鈥�478, doi: 10.21873/invivo.11263.

Implication of routine HIV testing program in Infectious diseases centre of 91桃色 Hospital Santaros Klinikos.

The goal of the study was to evaluate the feasibility and clinical effectiveness of fully integrated nontargeted opt-out rapid HIV screening program. Obtained results showed that routine HIV testing in infectious disease admissions as a policy is acceptable, feasible, and sustainable, also can be cost-effective. The study is in progress.

Direct-acting antivirals Ombitasvir/Paritaprevir/Ritonavir plus Dasabuvir with or without Ribavirin in HCV genotype 1-infected treatment-na茂ve or treatment-experienced patients: real-life experience in Lithuania and Latvia.

The aim of the study was to evaluate the efficacy and safety of OBV/PTV/r+DSV卤RBV therapy in treatment-na茂ve and treatment-experienced GT1-infected patients. The sustained virologic response at 12 weeks following the end of treatment was achieved in 96.8% non-transplanted and in all transplanted patients. This real-life study demonstrated the effectiveness and safety of OBV/PTV/r+DSV卤RBV in HCV GT1 patients, including patients with cirrhosis, liver transplants and those who failed previous antiviral therapy.

Main publication:

Jancoriene L., Polubenko K., Kazenaite E., Buivydiene A., Jakutiene J., Tolmane I., Jeruma A., Radzisauskiene D., Mockiene E., Ambrozaitis A. 2018. Direct-acting antivirals Ombitasvir/Paritaprevir/Ritonavir + Dasabuvir with or without Ribavirin in HCV genotype 1-infected treatment-na茂ve or treatment experienced patients with or without cirrhosis: real-life experience in Lithuania and Latvia. Hepatitis Monthly, vol. 18, no 1, Art. no e62105, Art no e62105 [1-10], doi: 10.5812/hepatmon.62105.

Ethiopathogenesis, Diagnosis and Treatment of Infectious, Inflammatory and Autoimmune Skin Diseases, as Well as Cutaneous Cancerous Lesions: Basic and Clinical Investigations, Implementation of Innovative Technologies. Prof. Dr. M. Bylait臈-Bu膷inskien臈. 2014鈥�2018.

We aim to evaluate the incidence, epidemiological and clinical correlation of basal cell carcinomas (BCC) in Lithuania, to compare the most common clinical-morphological forms in different localization of the body with the immunohistochemical data, and to analize the correlation of biomarkers with the subtypes of BCC. The study in the field of dermatooncology is suspended, as the PhD student is on academical leave.

Main publications:

Kandolf Sekulovic L., Guo J., Agarwala S., Hauschild A., McArthur G., Cinat G., Wainstein A., Caglevic C., Lorigan P., Gogas H., Alvarez M., Duncombe R., Lebbe C., Peris K., Rutkowski P., Stratigos A., Forsea A.M., De La Cruz Merino L., Kukushkina M., Dummer R., Hoeller C., Gorry C., Bastholt L., Herceg D., Neyns B., Vieira R., Arenberger P., Bylaite-Bucinskiene M., Babovic N., Banjin M., Putnik K., Todorovic V., Kirov K., Ocvirk J., Zhukavets A., Ymeri A., Stojkovski I., Garbe C. 2018. Access to innovative medicines for metastatic melanoma worldwide: Melanoma World Society and European Association of Dermato-oncology survey in 34 countries. Eur J Cancer, vol. 104, p. 201鈥�209, doi: 10.1016/j.ejca.2018.09.013.

Staseviciene D., Chomiciene A., Malinauskiene L., Grigaitiene J. 2018. Allergic contact dermatitis caused by laurel fruit oil. Journal of the European Academy of Dermatology and Venereology, vol. 32, iss. 11, e428-e429, doi: 10.1111/jdv.15031.

Tamulyte G., Lauraitis J., Ganceviciene R., Grigaitiene J., Zouboulis C.C. 2018. Cowpox virus infection in two brothers with possible human-to-human transmission. Journal of the European Academy of Dermatology and Venereology, vol. 33, no 1, e8-e10, doi: 10.1111/jdv.15103.

National Research Projects

Research Council of Lithuania. Seasonal Influenza Vaccine Effectiveness in Preventing from Hospitalization due to Influenza: Case-control Study (No. SEN-03/2015). Prof. A. Ambrozaitis, Prof. L. Jan膷orien臈, B. Zablockien臈. 2015鈥�2018.

The objective was to measure seasonal influenza vaccine effectiveness (SIVE) against influenza illness in patients admitted to hospital during the 2015鈥�2018 influenza seasons. A test-negative case-control study was performed in two university hospitals of Lithuania. Influenza and other respiratory pathogens were confirmed by multiplex RT-PCR. In collaboration with the European hospital influenza vaccine effectiveness network a multicentre test negative case control study was initiated in the hospitals of 11 European countries to measure influenza vaccine effectiveness against laboratory confirmed hospitalised influenza among people aged 鈮�65 years.
Poster presentation was presented at ECCMID conference 2018.

International Research Projects

Patch Testing With Propolis of Different Origin in Different Countries (since 2017). In collaboration with Gothenburg University, Sahlgrenska University Hospital, Department of Dermatology, Gothenburg, Sweden. Assoc. Prof. Dr. L. Malinauskien臈, Dr. J. Grigaitien臈.

The aim is to compare the frequencies of contact allergy to propolis in the participating countries, and to investigate if there is a difference in frequencies of contact allergy to propolis of different origins.

International Network on Hepatitis in Substance Users (INHSU).

The objective of INHSU is to create a global network that works with local partners to support health care workers, policy makers, researchers and people who use drugs to increase hepatitis C prevention and care. All-oral direct-acting antiviral drugs (DAAs) for hepatitis C virus, which have response rates of 95% or more, represent a major clinical advance. However, the high list price of DAAs has led many governments to restrict their reimbursement. We reviewed the availability of, and national criteria for, interferon-free DAA reimbursement among countries in the European Union and European Economic Area, and Switzerland. Reimbursement documentation was reviewed between Nov 18, 2016, and Aug 1, 2017.

Main publication:

Marshall A.D., Cunningham E.B., Nielsen S., Aghemo A., Alho H., et al. [From VU Faculty of Medicine Jancorien臈, L.]. 2018. International Network on Hepatitis in Substance Users (INHSU). Restrictions for reimbursement of interferon-free direct-acting antiviral drugs for HCV infection in Europe. Lancet Gastroenterol Hepatol., vol. 3, no 2, p. 125鈥�133, doi: 10.1016/S2468-1253(17)30284-4.

Contractual Research

Clinical and Virological Outcome of European Patients Infected With HIV. Prof. R. Matulionyt臈.

This multi-national, multi-center study aims to determine and evaluate the clinical virological outcomes of European patients infected with HIV within the frame of Copenhagen HIV Programme, initiated by University of Copenhagen, Faculty of Health Sciences. In total 120 patients were enrolled into the novel EuroSIDA cohort of HIV and HCV co-infected patients. The study is in process.

Main publications:

Peters L., Laut K., Resnati C., Leen C., Falconer K., Trofimova T., Paduta D., Gatell J., Rauch A., Lacombe K., Domingo P., Chkhartishvili N., Zangerle R., Matulionyte R., Mitsura, V., Benfield T., Khromova I., Lundgren J., Rockstroh J., Mocroft A. 2018. Uptake of hepatitis C virus treatment in HIV/hepatitis C virus-coinfected patients across Europe in the era of direct-acting antivirals. AIDS, doi: 10.1097/QAD.0000000000001928.

Shepherd L., Borges 脕.H., Harvey R., Bower M., Grulich A., Silverberg M., et al.; EuroSIDA in EuroCOORD (From VU Faculty of Medicine R. Matulionyte). 2018. The extent of B-cell activation and dysfunction preceding lymphoma development in HIV-positive people. HIV Med., vol. 19, iss. 2, p. 90鈥�101, doi: 10.1111/hiv.12546.

Cozzi-Lepri A., Zangerle R., Machala L., Zilmer K., Ristola M., Pradier C., et al.; EuroSIDA Study Group (From VU Faculty of Medicine R. Matulionyte). 2018. Incidence of cancer and overall risk of mortality in individuals treated with raltegravir-based and non-raltegravir-based combination antiretroviral therapy regimens. HIV Med., vol. 19, iss. 2, p. 102鈥�117, doi: 10.1111/hiv.12557.

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Investigating the Efficacy and Safety of Multiple Dupilumab Dose Regimens Administered as Monotherapy for Maintaining Treatment Response in Patients with Atopic Dermatitis. Prof. M. Bylait臈-Bu膷inskien臈, Dr. J. Grigaitien臈, Dr. E. Auk拧tuolien臈. 2015鈥�2019.

The aim of this phase 3 study was to evaluate the safety and efficacy of multiple dupilumab dose regimens administered as monotherapy for maintaining treatment response in patients with atopic dermatitis patients. In total 4 patients are in continuation phase. No adverse events or serious drug-related adverse events, and no treatment discontinuations. The study is in process.

Long Term Clear Skin Maintenance Treatment Optimization in Patients with Moderate to Severe Chronic Plaque Psoriasis: A Randomized, Multicenter, Open-Label with Blinded-Assessment, Comparative, 52 Weaks Study to Evaluate the Efficacy, Safety and Tolerability of Secukinumab 300 Mg. Prof. M. Bylait臈-Bu膷inskien臈, T. Karmazien臈, M. Krivickait臈. 2016鈥�2019.

The aim of the study was to evaluate the safety, efficacy and tolerability of secukinumab 300 mg in patients with moderate to severe chronic plaque psoriasis. Two patients are already involved. No adverse events or serious drug-related adverse events, and no treatment discontinuations.

A Multicenter, Double-Blind, Randomized Parallel, Vehicle-Controlled Study to Evaluate the Efficacy and Safety of P-3058 10% Nail Solution in the Treatment of Onychomycosis. Prof. M. Bylait臈-Bu膷inskien臈, Assoc. Prof. I. Mar膷iukaitien臈, Dr. J. Grigaitien臈, Dr. E. Auk拧tuolien臈, J. Barauskien臈, M. Krivickait臈. 2016鈥�2018.

The aim of this multicentre observational study was to evaluate the safety and effectiveness of P-3058 10% nail solution in the treatment of onychomycosis. All patients who met study inclusion criteria were included into study.

A Long Term Follow-up Study to Evaluate the Durability of Virologic Response and/or Viral Resistance of Subjects with Chronic Hepatitis C Who Have Been Previously Treated with Investigational Drugs. Prof. L. Jan膷orien臈.

The aim of this multicentre observational study was to evaluate the long-term durability of virologic response and/or viral resistance of subjects with CHC, who have been previously treated with investigational drugs. Study is in progress.

RESPOND C Study. Retrospective Cross Sectional Epidemiological Study on Chronic HCV Infection in the Baltic States and Ukraine: Basic Virus, Patient and Disease Characteristics in Diagnosed HCV Patients under Care. Prof. L. Jan膷orien臈.

The aim of the study was to assess the current patterns of hepatitis C virus (HCV) genotype (GT) and subtype distribution in CHC patients. This study included 1451 CHC patients. Distribution of HCV GT among patients with chronic HCV infection was as follows: GT1, 66.4%; GT3, 28.1; and GT2, 4.1%. The GT1b subtype was the most prevalent (79.4%) among GT1 patients. There were 69.6% treatment-na茂ve and 30.4% treatment-experienced patients. The majority of patients (85.9%) underwent treatment with a PEG-IFN regimen. The study is completed.

RELY study. Multi-center cross-sectional study to evaluate basic demographic, disease characteristics and referral pathway pattern in patients with chronic HCV infection and either HIV co-infection, CKD or status post-transplant in routine clinical settings in the Baltic States. Prof. A. Ambrozaitis, Prof. R. Matulionyt臈, Prof. L. Jan膷orien臈. 2017-2018.

A total of 396 patients with chronic HCV infection were enrolled into the study. Of them, 296 (74.7%) subjects had HIV co-infection, 68 (17.2%) subjects had CKD, and 46 (11.6%) subjects had transplanted liver and/or kidney.

Of 396 enrolled patients with chronic HCV infection, 296 (74.7%) subjects had HIV co-infection, 68 (17.2%) subjects had CKD, and 46 (11.6%) subjects had transplanted liver and/or kidney. All 396 subjects were diagnosed with CHC (mean time since the diagnosis of CHC - 6.5 years). The predominant HCV genotypes were genotype 1 (GT1a, 21.0%; GT1b, 39.6%) followed by genotype 3 (30.3%). There were 254 (64.2%) subjects with liver fibrosis stages F0-F2, 58 (14.6%) subjects with fibrosis stage F3, and 40 (10.1%) subjects with fibrosis stage F4 (cirrhosis). The most common reasons for HCV testing included HIV infection and intravenous drug use. Injecting drug use was the most common assumed HCV transmission route.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Warren Alpert Medical School at Brown University, Providence, RI (USA)
Ludwig 鈥� Maximilians University, Munich (Germany)
Sk氓ne university hospital, Lund University, Department of occupational and environmental dermatology (Sweden)
Malmo University (Sweden)

OTHER SCIENTIFIC ACTIVITIES

Prof. L. Jan膷orien臈 鈥�

member of the European Association of the Study of the Liver, ;
member of the International Society of Travel Medicine, ;
member of the Central European Vaccination Awareness Group;
member of the European Society of Clinical Microbiology and Infectious Diseases, ;
board member of the Lithuanian Society of Infectious Diseases, ;
member of the Lithuanian Society of Gastroenterology, t.

Prof. A. Ambrozaitis 鈥�

board member of the Lithuanian Society of Infectious Diseases, ;
country representative and member of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), ;
national representative and board member of the Infectious Diseases Section of European Union of Medical Specialists (UEMS), t;
editor-in-chief of the journal Infekcin臈s ligos (Infectious Diseases), ;
editorial board member of the journals HIV&AIDS Review: International Journal of HIV-related Problems, ; Sveikatos mokslai (Health Sciences),; Internistas (Internist), ; Acta medica Lituanica, ;

Prof. R. Matulionyt臈 鈥�

chair of the Vilnius Society of Infectious Diseases, ;
board member of the Lithuanian Society of Infectious Diseases, ;
member of the European Society of Clinical Microbiology and Infectious Diseases, ;
ESCMID Study Group for Antimicrobial Stewardship (ESGAP). A European consensus: ESCMID generic competencies in antimicrobial prescribing and stewardship. Panel member, country coordinator; ;
member of the European AIDS Clinical Society, ;
steering committee member for 2017鈥�2022 of the multi-centre study group EuroSIDA;
coordinator in the partnership of 91桃色 Hospital Santaros Klinikos in the EU project 761319 鈥� Joint Action on integrating prevention, testing and link to care strategies across HIV, viral hepatitis, TB and STIs in Europe (INTEGRATE);
member of the Action plan for HIV/AIDS and STI Prevention and Control 2018鈥�2020, Lithuania.

Prof. M. Bylait臈-Bu膷inskien臈 鈥�

president of the Lithuanian Society of Dermatovenereology, ;
board member of the European Association of Dermato Oncology, ;
board member of the Baltic association of Dermatovenereologists, ;
member of the European Academy of Dermatology and Venereology (EADV), ;
member of the European Dermatology Forum, ;
member of the European Society for Pediatric Dermatology (ESPD), ;
member of the International Society of Dermatology, ;
editorial board of the Journal of Health Sciences;
editorial board of the Journal of Lithianian鈥檚 Obstetrics and Gynecology;
editorial board member of the journal Sveikatos mokslai (Health Sciences), .

Assoc. Prof. R. Gancevi膷ien臈 鈥�

board member of the Lithuanian Society of Dermatovenereology, ;
member of the European Academy of Dermatology and Venereology,;
member and board member of the local Euromelanoma Committee;
editorial board member of the Journal of Dermato-Endocrinology, Landes Biosciences Member of the Scientific Technical Committee Cosmetics of Lithuanian Department for Standardization.

A. Stikleryt臈 鈥�

member of the European Society of Clinical Virology, ;
member of the Lithuanian Society of Infectious Diseases, .

Assist. Dr. J. Grigaitien臈 鈥�

member of the Lithuanian Society of Dermatovenereology,;
member of Lithuanian society of Allergology and clinical immunology, ;
member of the Lithuanian Society of Lasers:
national representative and board member of the Dermato-Venerology Section of European Union of Medical Specialists (UEMS), .

Assist. and doctoral stud. B. Zablockien臈 鈥�

member of the Lithuanian Society of Infectious Diseases, ;
member of the European Society of Clinical Microbiology and Infectious Diseases, ;
member of Lithuanian Society of Pulmonologists, .

Lect. T. Karmazien臈 鈥�

member of the Lithuanian Society of Dermatovenereology, ;
member of the European Academy of Dermatology and Venereology, .

Lect. and doctoral stud. I. Kisielien臈 鈥�

member of the Lithuanian Society of Dermatovenereology, .

Lect. T. Raudonis 鈥�

member of the Lithuanian Society of Dermatovenereology, ;
member of the European Academy of Dermatology and Venereology, .

Lect. A. Marcinkut臈 鈥�

member of the Lithuanian Society of Infectious Diseases, ;
member of the European Society of Clinical Microbiology and Infectious Diseases, .

Lect. and doctoral stud. 贰.&苍产蝉辫;惭补迟耻濒测迟臈 鈥�

member of the Lithuanian Society of Infectious Diseases, ;
member of the European Society of Clinical Microbiology and Infectious Diseases, ;
member of the European AIDS Clinical Society, ;
specialist in the EU project 761319 (partner 鈥� 91桃色 Hospital Santaros Klinikos) 鈥� Joint Action on integrating prevention, testing and link to care strategies across HIV, viral hepatitis, TB and STIs in Europe (INTEGRATE);
national representative Trainee Association the European Society of Clinical Microbiology and Infectious Diseases.

Lect. K. 沤virblyt臈-Skrebut臈nien臈 鈥�

member of the Lithuanian Society of Infectious Diseases, .

MOST IMPORTANT PARTICIPATION CASES OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

Raimonda Matulionyt臈, Arvydas Ambrozaitis, Ligita Jan膷orien臈, from 2016 till 2018, appointed as working group members by the order of Ministry of Health of the Republic of Lithuania in relation with amendment of Order No V-384 by the Minister of Health of the Republic of Lithuania of 3 May 2010 Regarding approval of arrangements for diagnostics and treatment of the human immunodeficiency virus disease compensated from the resources of the compulsory health insurance fund budget.

Arvydas Ambrozaitis, Ligita Jan膷orien臈, Raimonda Matulionyt臈, from 2015 till now, National Immunoprophylaxis programe 2014鈥�2018 and Programme for 2019鈥�2023, Members of Independent Experts (advisors, consultants) group.

Raimonda Matulionyt臈 during periods 2015鈥�2017 and 2018鈥�2020. Member of Coordinating Board for National Action Plan (AP) on HIV/AIDS and STI Prevention and Control, (SAM 寞sakymas / Order of Ministry of Health of the Republic of Lithuania Nr./No V-1191, 2015-10-26; Nr. V-451, 2017-04-19).

Raimonda Matulionyt臈, member of Experts group under Lithuanian Ministry of Health Expert group on addressing the issues related with the emergence and spread of antimicrobial resistant micro-organisms.

Ligita Jan膷orien臈, Raimonda Matulionyt臈, members of Expert group under Lithuanian Ministry of Health for the preparation of National guidelines for the rational use of antimicrobials and for the preparation of draft version of guidelines for the selection of the recommended first-line and reserve antimicrobials.

Raimonda Matulionyt臈, El啪bieta Matulyt臈, scientific members of EU project 761319 (partner 鈥� 91桃色 Hospital Santaros Klinikos) 鈥� Joint Action on integrating prevention, testing and link to care strategies across HIV, viral hepatitis, TB and STIs in Europe (INTEGRATE).

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

School of Eczema

CLINIC OF CHEST DISEASES, IMMUNOLOGY AND ALLERGOLOGY

2 Santari拧ki懦, LT-08661 Vilnius
Tel. 2501871
E-mail: ;

Head 鈥� Prof. Dr. Edvardas Danila

Department of Thoracic surgery of Center of Heart and Thoracic surgery

2 Santari拧ki懦, LT鈥�08661 Vilnius
Tel. 2 611 636
E-mail:

Head 鈥� Vytautas Jovai拧as

STAFF

Professor: Dr. E. Danila (part-time).
Associate professors: Habil.Dr. R. Janilionis (part-time), Dr. A. Bla啪ien臈 (part-time), Dr. R. Zablockis (part-time), Dr. V. Gruslys (part-time), Dr. L. Malinauskien臈 (part-time).
Assistants: Dr. V. 艩ileikien臈 (part-time), Dr. 沤. Jagelavi膷ius (part-time), Dr. A.Chomi膷ien臈 (part-time).
Lecturers: G. Cincelevi膷i奴t臈 (part-time), R. Gauronskait臈 (part-time), I. Pocien臈 (part-time), K. Lau啪ikait臈 (part-time).
Research fellows: Habil. Dr. R. Dubakien臈 (part-time), Dr. V. Kvedarien臈 (part-time), Dr. L. Malinauskien臈 (part-time), J. Ra膷kauskien臈 (part-time).
Doctoral students: R. Aleksonien臈, E. Jurevi膷ien臈, R. Stankevi膷i奴t臈, K. Linauskien臈.
Sudents鈥� scientific groups of:Pulmonology: scientific leader 鈥� Prof. E. Danila, coordinator 鈥� student J. Kogan; 18 members of the group. Allergy and clinic immunology: scientific leader 鈥� Dr. V. Kvedarien臈, coordinator 鈥� student G. Rudzikait臈; 15 members of the group.
Thoracic surgery: scientific leader 鈥� Dr. 沤. Jagelavi膷ius, coordinator 鈥� student A. Pi拧膷ikait臈; 38 members of the group.

RESEARCH INTERESTS

Evaluation of the efficacy of the diagnostic and treatment methods in obstructive, interstitial, neoplastic and allergic lung diseases: diagnosis and management of intersticial lung diseases
Diagnosis and management of COPD and bronchial asthma; sensitivity to various kinds of desinfectants among the medical staff
Development of new technologies, methods of early cancer detection and treatment interventions
Improvement of the quality of life of cancer patients
Pleural disease, diagnostic procedures, pleural biopsy; diagnosis, epidemiological and clinical research of drug hypersensitivity
Allergen immunotherapy: selection of patients, efficacy of different methods and long term treatment results
Strategy and approaches of the surgical management of patients with different thoracic pathology

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Evaluation of Epidemiology and Efficacy of the Diagnostic and Treatment Methods in Lung and Allergic Diseases and Disorders. Prof. E. Danila, Prof. R. Dubakien臈, Assoc. Prof. Habil. Dr. R. Janilionis, Assoc. Prof. A. Bla啪ien臈, Assoc. Prof. R. Zablockis, Assoc. Prof. V. Gruslys, Assoc. Prof. L. Malinauskien臈, Dr. V. Kvedarien臈, Dr. V. 艩ileikien臈, Dr. 沤. Jagelavi膷ius, J. Ra膷kauskien臈, G. Cincilevi膷i奴t臈, R. Gauronskait臈, I. Pocien臈, K. Lau啪ikait臈, R. Aleksonien臈, E. Jurevi膷ien臈, R. Stankevi膷i奴t臈, K. Linauskien臈. 2014鈥�2018.

Main publications:

Ka膷臈nien臈 A., Danila E., Cic臈nas S., Smailyt臈 G. 2018. Suicide risk among lung cancer patients in Lithuania. Clin Respir J, no 12, 2455鈥�2456.

Diktanas S., Vasiliauskien臈 E., Polubenko K., Danila E., 膶eledinait臈 I., Boreikait臈 E., Misi奴nas K. 2018. Factors associated with persistent sputum positivity at the end of the second month of tuberculosis treatment in Lithuania. Tuberc Respir Dis, no 81, p. 233鈥�240.

Rich A., Baldwin D., Alfageme I., Beckett P., Berghmans T, Brincat S., Burghuber O., Corlateanu A., Cufer T., Damhuis R., Danila E., Domagala-Kulawik J., Elia S., Gaga M., Goksel T., Grigoriu B., Hillerdal G., Huber R.M., Jakobsen E., Jonsson S., Jovanovic D., Kavcova E., Konsoulova A., Laisaar T., Makitaro R., Mehic B., Milroy R., Moldvay J., Morgan R., Nanushi M., Paesmans M., Putora P.M., Samarzija M., Scherpereel A., Schlesser M., Sculier J.-P., Skrickova J., Sotto-Mayor R., Strand T.-E., Schil P.V., Blum T.-G. 2018. Achieving thoracic oncology data collection in Europe: a precursor study in 35 countries. BMC Cancer, no 18, 1144 (1鈥�12).

Diagnosis and treatment of interstitial lung diseases.
The aim of the study was to evaluate the significance of bronchoalveolar lavage fluid examination in sarcoid patients and patients with rare interstitial disorders (eosinophilic pneumonia, hypersensitivity pneumonitis). Clinical symptoms, cell differentials and distribution of lymphocyte subgroups in BALF, chest X-ray, spirometric indices, blood gases were evaluated.

Assessment of pulmonary function of patients with lung diseases.
Comparison of different methods for evaluation of bronchial obstruction. Evaluation of lung ventilation reserve with different methods of lung ventilation reserve evaluation.

Main publication:

Ariel A., Altraja A., Belevskiy A., Boros P.W., Danila E., Fle啪ar M., Koblizek V., Fridlender Z.G., Kostov K., Krams A., Milenkovic B., Somfay A., Tkacova R., Tudoric N., Ulmeanu R., Valipour A. 2018. Inhaled therapies in patients with moderate COPD in clinical practice: current thinking. Int J COPD, no 13, p. 45鈥�56.

D鈥揹imer levels in pleural fluid.
Significance of pleural fluid D-dimer concentration is evaluated in patients with pleural effusion. Pleural D-dimer levels are measured and compared with D-dimer concentrations in plasma. Pleural fluid LDH, protein, pH, and glucose levels are assessed as well. The study is in process.

Main publications:

Zablockis R., 沤urauskas E., Danila E., Gruslys V. 2018. Prognostic value of thyroid transcription factor-1 expression in patients with advanced lung adenocarcinoma. In Vivo, no 32, p. 1571鈥�1579.

Evaluation of pulmonary embolism risk in lung cancer patients.
The aim of the study was to assess the prevalence and risk factors of pulmonary embolism in advanced lung cancer patients. The study is in process.

Evaluation of hypersensitivity reactions to cytostatic drugs in patients with lung cancer.
The aim of the study was to evaluate type of adverse reactions to different type of cytostatic drugs in patients with lung cancer.

Differences between self-reported drug hypersensitivity reactions in Lithuanian adults and children.
The aim of study was to assess the prevalence of self-reported DHRs in adults and in children and to analyze the risk factors in both groups. Cross-sectional survey of a population was made.

Main publication:

Courbis A.L., Murray R.B., Arnavielhe S., Caimmi D. Bedbrook A., et al. [From VU Faculty of Medicine V. Kvedarien臈, A. Valiulis]. 2018. Electronic clinical decision support system for allergic rhinitis management: MASK e-CDSS. Clin Exp Allergy, vol. 48, iss. 12, p. 1640鈥�1653, doi: 10.1111/cea.13230.

Allergen immunotherapy: patients鈥� selection, efficacy of different methods and treatment results.
The aim of the study was to evaluate the clinical efficacy and adverse reactions in adults with allergic rhinoconjuctivitis with or without asthma. We conclude that treatment with ASIT (allergen-specific immunotherapy) is effective and safe.

Main publications:

Bousquet J., Agache I., Aliberti M.R., Angles R., Annesi-Maesano I., et al. [From VU Faculty of Medicine R. Dubakien臈, R. 臇mu啪yt臈, V. Kvedarien臈, R. Stukas, A. Valiulis]. 2018. Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - EIP on AHA Twinning Reference Site (GARD research demonstration project). Allergy, vol. 73, iss. 1, p. 77鈥�92.

Bousquet J., Devillier P., Arnavielhe S., Bedbrook A., Alexis-Alexandre G., et al. [From VU Faculty of Medicine V. Kvedarien臈, A. Valiulis]. 2018. Treatment of allergic rhinitis using mobile technology with real-world data: The MASK observational pilot study. Allergy, vol. 73, iss. 9, p. 1763鈥�1774.
Bousquet J., Devillier P., Anto J.M., et al. [From VU Faculty of Medicine V. Kvedarien臈, A. Valiulis]. 2018. Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study. Allergy, vol.73, no 8, p. 1622鈥�1631.

Metal contact allergy.
The aims of the study are to detect the most common contact allergens in the metal workers, to detect the depth of the penetration of the metals鈥� (nickel, cobalt and chrome) ions in the skin using pig skin as a human skin model and to evaluate pathophysiological reactions occurring during acute contact reaction to these metals by investigating various inflammatory cytokines. Data was obtained and analyzed from questionnaires of 185 metal workers. Results were presented as a poster in the annual Congress of the European society of Contact dermatitis in Manchester, UK.

Main publication:

Malinauskiene L. Contact allergy to a meteorite: An interesting consequence of nickel allergy. Contact Derm, vol. 79, iss. 1, p. 36鈥�37.

Strategy and tactics of the surgical management of patients with different thoracic pathology.
New surgical methods using ultrasound intraoperatively and VATS were elaborated for the surgical management of the patients with pleuropulmonary suppurations. The value of videomediastinoscopy and videoassisted thoracoscopic surgery in diagnostics and management of the patients was assessed.

National Research Projects

Improvement of tuberculosis prevention, diagnostics, treatment and improvement of practical skills (J02-CPVA-V-04-0002). Prof. E. Danila, Assoc. Prof. R. Zablockis, Assoc. Prof. V. Gruslys. 2018鈥�2021.

The goal of the project is to increase the qualifications of healthcare professionals in improving the epidemiological surveillance, prevention and control of tuberculosis, to improve knowledge of tuberculosis diagnostics, treatment management and to improve practical skills.

International Research Projects

Main publication:

Grabenhenrich L.B., Reich A., McBride D., Sprikkelman A., Roberts G. et al. [From VU Faculty of Medicine R. Dubakien臈]. 2018. Physician鈥檚 appraisal vs documented signs and symptoms in the interpretation of food challenge tests: The EuroPrevall birth cohort. Pediatr Allergy Immunol, vol. 29, p. 58鈥�65.

Presence of Unlabeled Formaldehyde in Cosmetic and Medications (Since 2016) In collaboration with Lund University, Sk氓ne university hospital, Department of occupational and environmental dermatology (Sweden), Assoc. prof. Dr. L. Malinauskien臈.

The aim of the study to analyse various topical medicines and cosmetic products for the presence of free formaldehyde especially if it is not labelled. We already analysed around 30 products using chomotropic acid and HPLC. The study is in process.

Main publications:

Linauskiene K., Isaksson M. 2018. Allergic contact dermatitis from formaldehyde mimicking impetigo and initiating rosacea. Contact Derm, vol. 78, no 5, p. 359鈥�361.

Tiplica G.S., Boralevi F., Konno P., Malinauskiene L., Kaszuba A., Laurens C., Saint-Aroman M., Delarue A. 2018. The regular use of an emollient improves symptoms of atopic dermatitis in children: a randomized controlled study. J Eur Acad Dermatol Venereol, vol. 32, no 7, p. 1180鈥�1187.

Textile Dye Allergy and Allergic Contact Dermatitis. Since 2012. In collaboration with Lund University, Sk氓ne university hospital, Department of occupational and environmental dermatology (Sweden). Assoc. Prof. Dr. L. Malinauskien臈.

The aim of the study is to detect which dyes used today for textile dyeing can be inducers of the contact allergy and contact allergic dermatitis. Extracts from over 100 textile items are made to test patients already shown to be allergic to the textile dye mix allergen. Another aim is to detect which method of extraction from the textile items is the best retrieving the highest concentration of the dye. We compared three methods (extraction in ultrasonic bath, in acetone, in ethanol and artificial sweat) and analysed the samples with HPLC. The study is in process.

Main publications:

Linauskien臈 K., Zimerson E., Antelmi A., Bruze M., Hagvall L., Hamnerius N., Hauksson I., Ryberg K., Isaksson M. 2018. Solvent Orange 60 is a potent contact sensitizer in occupational and everyday life. Contact Dermatitis, vol. 79, no 3, 13022, p. 123鈥�126.

Stasevi膷ien臈 D., Chomi膷ien臈 A., Malinauskien臈 L., Grigaitien臈 J. 2018. Allergic contact dermatitis caused by laurel fruit oil. J Eur Acad Dermatol Venereol, vol. 32, iss. 11, p. e428鈥揺429.

Selby A., Munro A., Grimshaw K.E., Cornelius V., Keil T. et al. [From VU Faculty of Medicine R. Dubakien臈]. 2018. Prevalence estimates and risk factors for early childhood wheeze across Europe: the EuroPrevall birth cohort. Thorax, vol. 73, no 11, p. 1049鈥�1061.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Sk氓ne university hospital, Lund University, Department of occupational and environmental dermatology (Sweden), Gothenburg University, Sahlgrenska University Hospital, Department of Dermatology, Gothenburg (Sweden).

OTHER SCIENTIFIC ACTIVITIES

Prof. E. Danila 鈥�

member of European Respiratory Society (ERS);
member of Lithuanian Society of Pulmonologists;
editorial board member of the journal Vaik懦 pulmonologija ir alergologija (Children鈥檚 Pulmonology and Allergology).

Prof. R. Dubakien臈 鈥�

member of the Lithuanian Academy of Sciences;
chairman of Allergology Commission of Lithuanian Academy of Sciences;
expert of the Research Council of Lithuania;
expert of MITA;
editor-in-chief of the journal Alergologija ir klinikin臈 imunologija (Allergology and Clinical Immunology);
editor-in-chief of the on-line journal Alergologija ir klinikin臈 imunologija (Allergology and Clinical Immunology);
editorial board member of the journals: Acta Medica Lithuania, Revue of Allergology and Clinical Immunology; Medicinos teorija ir praktika (Theory and Practice in Medicine);
member of the Lithuanian Immunology Society;
member of the European Academy of Allergy and Clinical Immunology;
head of online websites: , .

Assoc. Prof. A. Bla啪ien臈 鈥�

editorial board member of the journal Medicinos teorija ir praktika (Theory and Practice in Medicine),
editor-in-chief of the journal Alergija, astma, imunologija (Allergy Asthma Immunology);
member of the European Respiratory Society (ERS),
member of the European Academy of Allergy and Clinical Immunology,
member of the American Academy of Allergy, Asthma and Immunology,
member of American College of Allergy, Asthma and Immunology,
member of European Society of Immunodeficiency,
member of Lithuanian Society of Immunology, www.imcentras.lt/lid/;
member of Lithuanian Society of Pulmonologists,.

Assoc. Prof. L. Malinauskien臈 鈥�

member of the European Academy of Allergy and Clinical Immunology;
member of Lithuanian society of Allergology and clinical immunology;
member of European Society for Pigment research;
editorial board member of the journal Alergija, astma, imunologija (Allergy Asthma Immunology).

Assoc. Prof. R. Zablockis 鈥�

chairman of Lithuanian Society of Pulmonologists,
member of European Respiratory Society (ERS),
editor-in-chief of the journal Pulmonology News,
editorial board member of the journal Pulmonology and Allergology,

Assoc. Prof. Habil. Dr. R. Janilionis 鈥�

board member of the Lithuanian Society of Cardiothoracic Surgery, ;
board member of Vilnius Surgical Society;
member of European Respiratory Society (ERS), ;
member of the European Association for Cardio-Thoracic Surgery, ;
editorial board member of the journal Medicina, ;
editorial boad member of the journal Lithuanian Surgery,

Assoc. Prof. V. Gruslys 鈥�

member of Lithuanian Society of Thoracic and Cardiac Surgeons,;
member of European Respiratory Society (ERS), ;
board member of Lithuanian Society of Minimal Invasive Surgery,
member of Lithuanian Respiratory Society,

Research fellow V. Kvedarien臈 鈥�

editorial board member of the journal Pulmonologija, imunologija ir alergologija (Pulmonology, Immunology and Allergolgy);
vice-chairman of reviewer board of the journal Vaik懦 pulmonologija ir alergologija (Children鈥檚 Pulmonology and Allergology);
member of Allergology Commission of Lithuanian Academy of Sciences;
member of the European Academy of Allergy and Clinical Immunology;
member of UCB Institute of Allergy,
member of Lithuanian Society of Allergology and Clinical Immunology;
member of Allergic Rhinitis and its Impact on Asthma (ARIA);
member of European Network on Drug Allergy (ENDA);
member of Integrated Care Pathways for Airways Diseases (AIRWAYS-ICPs);
medical advisor of Lithuania Asthma Patient Association.

Assist. A. Chomi膷ien臈 鈥�

member of the European Academy of Allergy and Clinical Immunology,
member of Lithuanian Society of Allergology and Clinical Immunology,
editorial board member of the journal Alergija, astma, imunologija (Allergy Asthma Immunology).

Assist. V. 艩ileikien臈, Lect. Research fellow J. Ra膷kauskien臈, Lect. I. Pocien臈, Lect. G. Cincilevi膷i奴t臈, Doctoral stud. R. Aleksonien臈, Doctoral stud. E. Jurevi膷ien臈 鈥�

members of European Respiratory Society (ERS),
members of Lithuanian Society of Pulmonologists,

Assist. 沤. Jagelavi膷ius 鈥�

member of Lithuanian Society of Thoracic and Cardiac Surgeons, ;
member of European Society of Thoracic Surgeons (ESTS), ;
member of European Respiratory Society (ERS), .

Lect. K. Lau啪ikait臈 鈥�

member of European Respiratory Society (ERS);
member of Lithuanian Society of Pulmonologists.

Lect. R. Gauronskait臈 鈥�

member of European Respiratory Society (ERS),
member of Lithuanian Society of Pulmonologists,
member of World Sleep Society,

Doctoral stud. R. Stankevi膷i奴t臈 鈥�

member of the European Academy of Allergy and Clinical Immunology;
member of Lithuanian Society of Allergology and Clinical Immunology.

Doctoral stud. K. Linauskien臈 鈥�

member of Lithuanian society of Allergology and Clinical Immunology (LAKID);
member of the European Academy of Allergy and Clinical Immunology (EAACI);
member of European Society for Immunodeficiencies (ESID);
ESID junior country representative.

MOST IMPORTANT NATIONAL AND INTERNATIONAL AWARDS RECEIVED FOR R&D ACTIVITIES

Kotryna Linauskien臈鈥� Lithuanian Research Council award for academic achievements.
R奴ta Dubakien臈鈥� The State Commission of Lithuania Award (sculpture "Sraig臈") for the nurturance of the Lithuanian language.

MOST IMPORTANT PARTICIPATION CASES OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

R奴ta Dubakien臈鈥� prepared Lithuanian names of food allergens for the Bank of Terms of the Lithuanian State Commission.
Edvardas Danila 鈥� participation in the Lithuanian State Ministry of Health Tuberculosis Task Force.

consultations provided by the unit to the public or economic entities

Edvardas Danila 鈥� regular consultations for Lithuanian State Ministry of Health.
Edvardas Danila 鈥� advisory board for several pharmaceutical companies.
Rolandas Zablockis - regular consultations for Lithuanian State Ministry of Health.
Rolandas Zablockis 鈥� advisory board for several pharmaceutical companies.

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

R奴ta Dubakien臈鈥� lecture for students about allergies in Vilnius gymnasium "艩altin臈lis".
R奴ta Dubakien臈鈥� public lecture on the problems of allergy in M. Martinaitis鈥� Library of Raseiniai.
Edvardas Danila 鈥� lecture for students of Vilnius gymnasiums about interstitial lung diseases in 91桃色.
Edvardas Danila 鈥� seminar for students of Vilnius gymnasiums about lung diseases in 91桃色.

CLINIC OF NEUROLOGY AND NEUROSURGERY

2 Santari拧ki懦, LT-08661 Vilnius
Tel.: 236 5165, 8688 62744
E-mail:

Head 鈥� Prof. Dr. Dalius Jatu啪is

Centre of Neurology

2 Santari拧ki懦, LT-08661 Vilnius
Tel. 236 5095
E-mail: ;

Head 鈥� Prof. Dr. Gintaras Kaubrys

Centre of Neurosurgery

2 Santari拧ki懦, LT-08661 Vilnius
Tel. 869771394, 868743480
E-mail:

Head 鈥� Prof. Dr. Saulius Ro膷ka

STAFF

Professors: Dr. G. Kaubrys, Dr. R. Mameni拧kien臈, Dr. S. Ro膷ka.
Associate professors: Dr. R. Kizlaitien臈, Dr. J. Valaikien臈.
Assistants: E. Audronyt臈, Dr. N. Giedraitien臈, A. Jasionis, Dr. R. Kaladyt臈 Lokominien臈, Dr. A. Klima拧auskien臈, R. Masili奴nas, Dr. K. Ryli拧kien臈, Dr. A. Vaitkevi膷ius, Dr. A. Vilionskis , Dr. R. Kva拧膷evi膷ius
Lecturers: Dr. G. Terbetas, Dr. K. Laurik臈nas.
Junior research fellows: 沤. Chomanskis, A. Preik拧aitis.
Doctoral students: E. Audronyt臈, A. Jasionis, M. Kurminas, J. Kuzmickien臈, R. Masili奴nas, E. Sakalauskait臈-Juodeikien臈, D. Valadkevi膷ien臈, A. Gavrilova, 沤. Chomanskis.
Students鈥� scientific groups of:
Neurology: scientific leader 鈥� Dr. K. Ryli拧kien臈, coordinator 鈥� student A. Dapkut臈; 40 members of the group.
Neurosurgery: scientific leader 鈥� Dr. G. Terbetas, coordinator 鈥� L. 艩ala拧evi膷ius; 32 members of the group.

RESEARCH INTERESTS

Cognitive disorders in neurodegenerative, cerebrovascular, demyelinating diseases and epilepsy
Diagnostic evaluation and treatment of cerebrovascular disorders, headache, dizziness, traumatic brain injuries degenerative spinal diseases and cerebral neoplasms
Historical research: nervous system diseases in the first half of the nineteenth-century Vilnius

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Assessment of New Diagnostic and Treatment Methods in Neurology and Neurosurgery (Cerebrovascular, Neurodegenerative, Oncological, Demyelinating Diseases, Epilepsy, Traumatic Injury, Degenerative Spinal Diseases). Prof. D. Jatu啪is. 2014鈥�2018.

Center of Neurology continued clinical research focussed on clinical and cognitive characteristics of different neurological disorders (Alzheimer鈥檚 disease, multiple sclerosis, Parkinson鈥檚 disease, epilepsy); assessment and practical application of new diagnostic and treatment methods in cerebrovascular, demyelinating, neurodegenerative diseases, epilepsy, headache and dizziness; evaluation of neurophysiological and clinical peculiarities of patients with critical illness; description of artworks related to neurology and artists with neurological disorders.

Main publications:

Sakalauskait臈-Juodeikien臈 E., Armalien臈 G., Kizlaitien臈 R., Bagdonait臈 L., Giedraitien臈 N., Mickevi膷ien臈 D., Rastenyt臈 D., Kaubrys G., Jatu啪is D. 2018. Detection of aquaporin-4 antibodies for patients with CNS inflammatory demyelinating diseases other than typical MS in Lithuania. Brain Behav, vol 8, no 11, e01129.

Giedraitiene N., Kaubrys G., Kizlaitiene R. 2018. Cognition during and after multiple sclerosis relapse as assessed with the brief international cognitive assessment for multiple sclerosis. Sci Rep, vol. 8, no. 1, 8169.

Mameni拧kien臈 R., Wolf P. 2018. Precipitation and inhibition of seizures in focal epilepsies. Expert Rev Neurother, vol. 18, no. 4, p. 275鈥�287.

Diagnostic Evaluation and Treatment of Cerebrovascular Disorders, Traumatic Brain Injuries Degenerative Spinal Diseases and Cerebral Neoplasms. Prof. S. Ro膷ka. 2017鈥�2018.

Center of Neuroangiosurgery is establishing new methods of endovascular treatment of cerebrovascular disorders. Research in traumatic brain injury is concentrated to epidemiology and prognostic factors, as well as clinical evaluation of new monitoring devices. New modalities in minimally invasive degenerative spinal diseases management are being evaluated. Research in cerebral neoplasms is based on epidemiological studies and evaluation of new strategies of surgical treatment.

Main publications:

Kwon, C.S., Awar, O.A., Ripa, V., Said, G., Rocka, S. 2018. Basal cell carcinoma of the scalp with destruction and invasion into the calvarium and dura mater: Report of 7 cases and review of literature. J Clin Neurosci, vol. 47, p. 190鈥�197.

Chmieliauskas S., Anuzyte J.S., Liucvaikyte J., Laima S., Jurolaic E., Rocka S., Fomin D., Stasiuniene J., Jasulaitis A. 2018. Importance of effusion of blood under the dura mater in forensic medicine. Medicine, vol. 97, no 39, 97:39 (e12567),

Nervous System Diseases in the First Half of the Nineteenth-century Vilnius. Prof. D. Jatu啪is and E. Sakalauskait臈-Juodeikien臈. 2015鈥�2019.

The aim of this study is to reveal the origins of neurology in the first half of the 19th century in Vilnius: to show how the basic medical systems influenced the perception of nervous system diseases and treatment options, to evaluate the perception of aethiology, pathogenesis, symptoms, prophylaxis and treatment methods of nervous system diseases, to discover the origins of neurosurgery, to reveal the principles of the human cognition research.

Main publication:

Sakalauskait臈-Juodeikien臈, E., Jatu啪is, D., Kaubrys, S. 2018. Plica Polonica: from national plague to death of the disease in the nineteenth century Vilnius. Indian Journal of Dermatology, Venereology and Leprology: Wolters Kluwer, vol. 84, no 4, p. 510鈥�514, doi: 10.4103/ijdvl.IJDVL_673_17.

Projects Supported by the Research Council of Lithuania

Virtual Reality Technologies to Facilitate Epley Maneuver for Healthy Volunteers. Teaching assist. R. Masili奴nas. 2017鈥�2018.
Benign Paroxysmal Positional Vertigo (BPPV) is one of the most common vestibular pathologies. Correct application of positional maneuvers is an effective and inexpensive way to diagnose and treat BPPV. However, the particle-repositioning maneuvers are currently underused due to physicians鈥� lack of knowledge how to apply them and the lack of time in ambulatory setting. The primary goal of this project is to evaluate the therapeutic benefit of a virtual reality device and a mobile application developed speciffically to facilitate the performance of Epley maneuver for healthy volunteers.

National Research Projects

National Science Program Healthy Ageing. Project: SEN-05/2015 Research on Synthesis Regulation of Proteins, Associated with the Development of Alzheimer鈥檚 Disease in cooperation with the 91桃色 Institute of Biotechnology. Principal Investigator at 91桃色 IBT (VU Life Sciences Center) - Prof. K. Sasnauskas, Principal Investigator at VUH SK - Prof. G. Kaubrys. 01. Jan. 2016鈥�31. Dec. 2019.
In 2018, research and data analysis were continued. The goal of the project is to create an immunochemical ELISA-based method, which could allow testing of all potential polypeptides, encoded by the small open reading frames of the genes related to Alzheimer鈥檚 disease. These new methods may help to determine the role of synthesized small polypeptides in the fundamental changes of the protein synthesis in ageing and Alzheimer鈥檚 disease. The results of the project may provide new knowledge about the AD-related regulation of protein synthesis and new opportunities for the prevention and early diagnosis of Alzheimer鈥檚 disease.

Clinical research Impact of Modified Lindy-Hop Dance Therapy on Motor Condition and Quality of Life in Early Parkinson's Disease in collaboration with Vilnius Gediminas Technical University. Assist. R. Kaladyt臈 Lokominien臈. 2015鈥�2019.

In 2018, further analysis of data was performed. Quantitative assessment of dance therapy influence on upper limb biomechanics and gait for patients with Parkinson's disease was continued. Presentation at the international conference BIOMDLORE: Luk拧ys D, Jatu啪is D, Kaladyt臈-Lokominien臈 R, Bunevi膷i奴t臈 R, Sawicki A, Griskevi膷ius J. Differentiation of Gait Using Principal Component Analysis and Application for Parkinson鈥檚 Disease Monitoring.

Clinical research Ataxia and Gait Impairment in Multiple Sclerosis Patients in collaboration with Vilnius Gediminas Technical University. Assoc. prof. R. Kizlaitien臈. 2015-ongoing.

In 2018, data was collected and analysed. Objective quantitative parameters for more accurate evaluation of coordination in patients with multiple sclerosis were searched by instrumented biomechanical analysis of upper extremity movements.

Main publication:

Daunoravi膷ien臈 K., 沤i啪ien臈 J.,Gri拧kevi膷ius J., Pauk J., Ov膷inikova A., Kizlaitien臈 R., Kaubrys G.F. 2018. Quantitative assessment of upper extremities motor function in multiple sclerosis. Technology and Health Care, vol. 26, iss. S2, p. 647鈥�653, doi: 10.3233/THC-182511.

Analysis of Brain Tumors Prognostic Factors and Early Response with Visual Biomarkers in coperation with National Cancer Institute (No. MIP-015/2014; KT2014-27). Dr. E. Aleknavi膷ius. 2014鈥�2019.

In 2018, follow-up of the patients, research and data analysis were continued. The results of the project may provide new insights and knowledge about prognostic factors of brain tumors and response to treatment.

International Research Projects

Collaborative European NeuroTrauma Effectiveness research in TBI: a prospective longitudinal observational study (CENTER-TBI), funded by 7BP; . Participants: Prof. Dr. S. Ro膷ka, A. Preik拧aitis.

The aim of the project is to collect high quality clinical, epidemiological, radiological and genetic database of traumatic brain injured patients. CENTER-TBI aims to advance the care for apatients with traumatic brain injury by better characterization trauma as a disease and indentifying the most effective clinical interventions for managing TBI.

Main publication:

Chmieliauskas, S., Anuzyte, J.S., Liucvaikyte, J., Laima, S., Jurolaic E., Rocka, S., Fomin, D., Stasiuniene, J., Jasulaitis, A. 2018. Importance of effusion of blood under the dura mater in forensic medicine: A STROBE - compliant retrospective study. Medicine (Baltimore), vol. 97, no 39, e12567, [1-7], doi: 10.1097/MD.0000000000012567.

Safe Implementation of Treatment of Stroke (SITS) - EAST Project. Participants: Dr. A. Vilionskis, R. Masiliunas, Prof. Dr. D. Jatu啪is.

Collaborative project with other stroke centers from Eastern and Central Europe: prospective international database of all acute stroke patients treated with reperfusion treatment.

The aim of project to collect demographic, clinical, radiological, treatment details of all acute ischemic stroke patients, treated with reperfusion treatment as 3 months follow up as well.

Main publications:

Vaclavik D., Vilionskis A., Jatuzis D., Karlinski M.A., Gdovinova Z., K玫rv J., Tsivgoulis G., Mikulik R. 2018. Clinical outcome of cardioembolic stroke treated by intravenous thrombolysis. Acta Neurol Scand, vol. 137, no. 3, 347鈥�355, doi: 10.1111/ane.12880.

Tsivgoulis G., Katsanos A.H., Giannopoulos G., Panagopoulou V., Jatuzis D., Lemmens R., Deftereos S., Kelly P.J. 2018. The role of colchicine in the prevention of cerebrovascular ischemia. Curr Pharm Des, vol. 24, no 6, p. 668-674, doi: 10.2174/1381612824666180116100310.

The Standardized Computer-based Organized Reporting of EEG (SCORE) Leader (coordinator) 鈥� Prof. R. Mameni拧kien臈. Since 2009.

The aim of the project was to create a computer-based system for EEG assessment and reporting. It was approved by the Commission on European Affairs of the ILAE. The working group produced a consensus proposal that went through a pan-European review process, organized by the European Chapter of the International Federation of Clinical Neurophysiology. SCORE software was constructed based on the terms and features of the Consensus statement and it was tested in the clinical practice.

E-pilepsy is a Pan-European Project. Leader (coordinator) 鈥� Prof. R. Mameni拧kien臈. Since 2011. Finished.

The primary aim of the project is to improve awareness and accessibility of surgery for epilepsy across different countries. Epilepsy surgery is an established treatment in the management of individuals with drug-resistant focal epilepsy. Epilepsy has established a consortium of 13 centres as associate partners, with a further 15 collaborating centres to drive this project. The primary expected outcome of the project is to increase the number and proportion of European children and adults cured of their refractory epilepsy by improving delivery of optimal epilepsy surgery throughout Europe. Aspects of Eepilepsy include: improving accessibility of information; facilitation of referral for assessment;improving tools for assessment; improving analysis of investigations as well as the training across different sites of individuals to be involved in assessment for epilepsy surgery.

Main publication:

Baud, M.O., Perneger, T., R谩cz, A., Pensel, M.C., Elger, C., Rydenhag, B., Malmgren, K., Cross, J.H., McKenna, G., Tisdall, M., Lamberink, H.J., Rheims, S., Ryvlin, P., Isnard, J., Maugui猫re, F., Arzimanoglou, A., Akkol, S., Deniz, K., Ozkara, C., Lossius, M., Rektor, I., K盲lvi盲inen, R., Vanhatalo, L.M., Dimova, P., Minkin, K., Staack, A.M., Steinhoff, B.J., Kalina, A., Krsek, P., Marusic, P., Jordan, Z., Fabo, D., Carrette, E., Boon, P., Rocka, S., Mameni拧kien臈, R., Vulliemoz, S., Pittau, F., Braun, K.P.J., Seeck, M. 2018. European trends in epilepsy surgery. Neurology, vol. 91, iss. 2, p. E96鈥揈106, doi: 10.1212/WNL.0000000000005776.

Current Status of Epilepsy Health Care for Adult Patients from Central and Eastern European Union Countries. Leader (Coordinator) - Prof. R. Mameniskiene. Since 2015.

The aim of this survey was to review and compare the current approaches to epilepsy management in central and eastern EU countries. Experts from Bulgaria, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia, and Slovenia participated in the project, focused on the epilepsy treatment of adults. We concluded that the lack of unified procedures pertaining to the evaluation and therapy of epilepsy is reflected by marked differences in access to treatment modalities for patients from CEEU countries.

International Multicenter Register: European Register of Antileptic Drugs and Pregnancy (EURAP) - a prospective observational study of pregnancies with antiepileptic drugs. Lithuanian involved in the project. Leader 鈥� Prof. R. Mameniskiene. Since 2005.
The aim was to collect data on the risk of antiepileptic drugs during pregnancy and share it in an international registry. At present, physicians from 42 countries in Europe, Oceania, Asia, Latin America and Africa are actively collaborating, and more than 23,000 pregnancies were registered. The primary goal is to compare the risk of major congenital malformations following maternal intake of different antiepileptic drugs (AEDs) and their combinations. Secondary objectives include the evaluation of any specific pattern of foetal abnormalities, dose-effect relationships, and other risk factors.

International Project on the EEG Changes during the Olfactory Stimulation in Patients with Epilepsy. Participant 鈥� Prof. R. Mameniskiene, 2013-ongoing.

The project aimed to investigate modulation (provocation or inhibition) of epileptiform discharges in mesial temporal lobe epilepsy versus idiopathic generalized epilepsy by olfactory stimulation compared with standard provocation methods. The underlying hypothesis was that any response would be more likely to occur in mesiotemporal epilepsy, considering the anatomical connections of the temporal lobe to the olfactory system.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Kaunas University of Technology (Lithuania)
National Cancer Institute (Lithuania)
Vilnius Gediminas Technical University (Lithuania)

OTHER SCIENTIFIC ACTIVITIES

Prof. D. Jatu啪is 鈥�

president of Lithuanian Stroke Association and Lithuanian Neurological Association;
executive editor of the journal Neurologijos seminarai (Seminars in Neurology);
fellow member of European Stroke Organization (FESO);
national coordinator of projects ESO-EAST (Enhancing and Accelerating Stroke Treatment; 5-year collaboration with selected physicians from Eastern countries to optimise stroke care in Eastern Europe) and SITS (Safe Implementation of Treatments in Stroke) and member of SITS-EAST;
leading Investigator in EuroHYP-1 and TWIST acute stroke trials;
member of Subspecialty Scientific Panel Stroke of the European Academy of Neurology (EAN);
National educational co-ordinator and member of the World Federation of Neurology

Prof. S. Ro膷ka 鈥�

president of Lithuanian Neurosurgical Society;
member of Lithuanian Society for Epileptology;
member of European Association of Neurosurgical Societies;
member of World Federation of Neurosurgical Societies;
member of Lithuanian Neuroscience Association.

Prof. G. Kaubrys 鈥�

member of the Council of the Lithuanian Neurological Association.
member of Subspecialty Scientific Panel Dementia and Cognitive Disorders of the European Academy of Neurology (EAN);
voting member of the Association for the Scientific Study of Consciousness (ASSC);
editorial board member of the journal Neurologijos seminarai (Seminars in neurology);
member of the World Federation of Neurology.

Prof. R. Mameni拧kien臈 鈥�

president of Lithuanian Society for Epileptology;
member of Subspecialty Scientific Panel Epilepsy of the European Academy of Neurology (EAN);
member of the Council of the Lithuanian Neurological Association;
cover art editor of the journal Seizure - European Journal of Epilepsy;
editor-in-chief of the journals Neurologijos seminarai (Seminars in neurology) and Nerv懦 ir psichikos ligos;
national coordinator in European Register of Antileptic Drugs and Pregnancy (EURAP);
national coordinator in the international registry of the treatment of refractory status epilepticus;
member of the Lithuanian Stroke Association;
member of the World Federation of Neurology.

Assoc. Prof. J. Valaikien臈 鈥�

editorial board member of the journal Neurologijos seminarai (Seminars in neurology);
member of the Council of the Lithuanian Society of Clinical Neurophysiology and Neurosonology;
member of Subspecialty Scientific Panel Neurosonology of the European Academy of Neurology (EAN);
member of Subspecialty Scientific Panel Infectious Diseases of the European Academy of Neurology (EAN);
member of the Lithuanian Neurological Association;
member of the Lithuanian Stroke Association;
member of the World Federation of Neurology.

Assoc. Prof. R. Kizlaitien臈 鈥�

member of the Council of the Lithuanian Neurological Association;
member of Subspecialty Scientific Panel Multiple Sclerosis and Demyelinated Diseases of the European Academy of Neurology (EAN);
member of the Lithuanian Stroke Association;
head of the Medical Advisory Board of Lithuanian Multiple Sclerosis Association.

Assoc. Prof. K. Laurik臈nas 鈥�

editorial board member of the journal Chirurgija (Surgery);
member of the Lithuanian Society of Vascular Surgery.

Lect. R. Kva拧膷evi膷ius 鈥�

member of Lithuanian Neurosurgical Society;
member of Baltic Neurosurgical Association;
member of European Association of Neurosurgical Societies;
member of World Federation of Neurosurgical Societies;
member of Lithuanian Society of Vertebrology.

Lect. G. Terbetas 鈥�

member of Lithuanian Neurosurgical Society;
member of Lithuanian Society of Vertebrology;
AOSpine member.

Assist. A. Vilionskis 鈥�

member of Council of Lithuanian Stroke Association;
fellow member of European Stroke Organization;
member of Lithuanian Neurological Association;
member of World Stroke Organization;
member of World Federation of Neurology.

Assist. R. Kaladyt臈-Lokominien臈 鈥�

member of the Council of Lithuanian Neurological Association;
member of Subspecialty Scientific Panel Movement Disorders of the European Academy of Neurology (EAN);
member of International Parkinson鈥檚 Disease and Movement Disorders Society;
member of Cochrane Collaboration Neurological Network
coordinator of Huntington鈥檚 Disease Coordination Centre.

Assist. K. Ryli拧kien臈 鈥�

member of Subspecialty Scientific Panel Headache of the European Academy of Neurology (EAN);
member of Neuro-ophthalmology and Neuro-otology Scientific Panel of European Academy of Neurology (EAN);
member of European Board of Neurology in European Union of Medical Specialists;
head of Neurology Panel of Students鈥� Research Network of 91桃色 Faculty of Medical.

Assist. R. Masili奴nas 鈥�

executive board member of the Nordic Stroke Society.

MOST IMPORTANT PARTICIPATION CASES OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

Participation in working groups and committees set by Lithuanian Health Ministry:

Stroke Integrated Healthcare Management Committee (Prof. Dalius Jatu啪is; Dr. Aleksandras Vilionskis)
Working Group on Neurology Medicine Norm Update (Prof. Dalius Jatu啪is; Prof. R奴ta Mameni拧kien臈, Dr. Au拧ra Klima拧auskien臈)

CONSULTATIONS PROVIDED BY THE UNIT TO THE PUBLIC OR ECONOMIC ENTITIES

Prof. Dalius Jatu啪is:

expert of projects in Lithuanian Business Support Agency;
expertise for State Health Care Accreditation Agency under the Ministry of Health;
expertise for The State Forensic Medicine Service.

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

Scientific popularization of TV, radio and Internet broadcasts (prof. Dalius Jatu啪is; prof. R奴ta Mameni拧kien臈, dr. Kristina Ryli拧kien臈, dr. Aleksandras Vilionskis, asist. Rytis Masili奴nas).
Epilepsy, Parkinson 鈥檚 disease, Multiple Sclerosis, Stroke, Migraine, Alzheimer鈥檚 Day Informative Events for the Public.

CLINIC OF PSYCHIATRY

29a Gele啪inio vilko, LT-03101 Vilnius
Tel. 239 8754
E-mail:

Head 鈥� Prof. Dr. Sigita Lesinskien臈

STAFF

Professors: Dr. S. Lesinskien臈, Dr. D. P奴ras, Dr. A. Germanavi膷ius (part-time).
Associate professors: Dr. A. 艩iurkut臈, Dr. A. Navickas, Dr. R. Vili奴nien臈, Dr. B. Diom拧ina (part-time).
Assistants: G. Bulotien臈, Dr. A. Deksnyt臈, E. Dlugauskas (part-time).
Lecturers (part-time).: Dr. A. Dervinyt臈-Bongarzoni, V. Rutkauskas, R. Bal膷i奴nas, V. Andrejauskien臈, M. Misevi膷臈, L. Bukelskis, I. Treigien臈, A. 艩apranauskien臈, R. Samu拧yt臈, M. Karnickas, D. Natkevi膷ien臈, J. Ulevi膷ien臈, S. A拧vydien臈, E. Pau啪ien臈, E. Petkut臈, J. Da拧kevi膷ien臈, V. Mickut臈, B. Did啪iokait臈, L. Andrikien臈, R. 沤idonien臈, A. Nemanien臈 .
Doctoral students: E. Dlugauskas, A. 艩ileikait臈.
Students鈥� scientific groups of:
Child and adolescent psychiatry: scientific leader 鈥� Prof. S. Lesinskien臈, coordinator 鈥� student R. 艩ambaras; 9 members of the group.
Psychiatry: scientific leader 鈥� Assoc. Prof. A.Navickas, coordinator 鈥� student A.Valentukevi膷i奴t臈; 54 members of the group.
Psychotherapy: scientific leader 鈥� Assoc. Prof. R. Vili奴nien臈, coordinator 鈥� student D. Rago啪a; 50 members of the group.

RESEARCH INTERESTS

Evaluation of functioning and quality of life of patients with psychiatric disorders
Analysis of outcome variables of the treatment of psychotic, affective and neurotic disorders
Different approaches on psychosocial rehabilitation and assertive outreach for comprehensive integrated community care for people with mental disorders in the community settings
Evaluation of services for people with mental illness and their carers

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Prevalence, Clinical Peculiarities of Psychotic, Affective and Neurotic Disorders; Relation of Treatment and Preventive Methods with Functioning of Patients and Quality of Their Life. Project leader: Assoc. Prof. A. Navickas. 2014鈥�2018.

During 2018, the clinic of psychiatry concentrated its research on: psychopathological structure of depressions, the associations of its structure with the course and prognosis of the disease; pathological imitative behavior and response preparation in schizophrenia; delirium in the cardiac intensive care unit; autoimmune damage relation to treatment resistance psychoses and the effectiveness of the ECT; changes of event-related potential P300 after ECT in patients with treatment-resistant psychiatric disorders; influence of 10 Hz rTMS treatment site selection on physiological and clinical outcome; CYP450 enzymes genetic polymorphism influence on treatment of affective disorders; Active participation at international conferences.

Main publications:

Serpytis, P., Navickas, P., Lukaviciute, L., Navickas, A., Aranauskas, R., Serpytis, R., Deksnyte, A., Glaveckaite, S., Petrulioniene, Z., Samalavicius, R. 2018. Gender-based differences in anxiety and depression following acute myocardial infarction. Arquivos Brasileiros de cardiologia. Rio de Janeiro: Sociedad Brasileira De Cardiologia, vol. 111, iss. 5, p. 676鈥�682, doi: 10.5935/abc.20180161.

Gancevi膷ien臈, R., Lukavi膷i奴t臈, L., Navickas, P., Navickas, A., Grigaitien臈, J., Zouboulis, C.C. 2018. Akn臈s 寞taka emociniams sutrikimams. Sveikatos mokslai (Health Sciences in Eastern Europe), vol. 28, nr. 3, p. 30鈥�35, doi:

Research on Suicide Behaviour and Implementation of the Suicide Prevention Methods in Lithuania. Project leader: Assoc. Prof. A. Navickas. 2014鈥�2018.

Further research of suicidal behavior in Lithuanian population, comparative analysis of suicides among EU countries. Active participation in international conferences.

Main publication:

Kazlauskien臈, J., Kac臈nien臈, A., Smailyt臈, G., Zagminas, K., Navickas, A., Bulotien臈, G. 2018. The risk factors for depression in Lithuanian breast cancer patients. Psycho-Oncology, vol. 27, iss. 10, doi: 10.1002/pon.4820.

Complex Care for Children with Mental and Developmental Disorders: Implementation of the Model and Evaluation of Need for Services. Project Leader - Prof. D. P奴ras. 2014鈥�2018.

Research was carried out on the need of services for children and adolescents with mental, behavioral and developmental disorders. Results identified substantial gaps in the system of services and the need for increasing quantity and quality of mental health services for children and adolescents. It was identified that the priority is to invest in development in specialized outpatient and day care services with teams of professionals in regional centers which cover catchment area of 200.000 to 300.00 of population. Recommendations of this research are reflected in publications. These recommendations were used by the Ministry of Health in formulation of guidelines for further development of child and adolescent mental health serrvices in the Republic of Lithuania.

Main publications:

Lesinskien臈, S., Girdzijauskien臈, S., Gintilien臈, G., Butkien臈, D., P奴ras, D., Goodman, R., Heiervang, E. 2018. Epidemiological study of child and adolescent psychiatric disorders in Lithuania. BMC Public Health, vol. 18, no. 548, [8], doi: 10.1186/s12889-018-5436-3.

Sourander, A., Chudal, R., Skokauskas, N., Al-Ansari, Ah.M., Brunstein Klomek, A.,路Pornnoppadol, Ch., Kolaitis, G., Maezono, J., Steinhausen, H.-C., Slobodskaya, H., Kaneko, H., Regmee, J., Li, L., Nguyen, M.H., Grimland, M., Osokina, O., Ong, S.H., Praharaj, S.K., Lesinskien臈, S., Fossum, S., Wiguna, T., Makasheva, V.A., Lehti, V. 2018. Unmet needs of child and adolescent psychiatrists among Asian and European countries: does the Human Development Index (HDI) count? European Child and Adolescent Psychiatry, vol. 27, iss. 1, p. 5鈥�8, doi: 10.1007/s00787-017-1095-7.

Cheng S., Keyes K.M., Bitfoi A., Carta M.G., Koc C., Goelitz D., Otten R., Lesinskiene S., Mihova Z., Pez O., Kovess-Masfety V. 2018. Understanding parent-teacher agreement of the Strengths and Difficulties Questionaire (SDQ): Comaprison across seven European countries. International Journal of Methods in Psychiatric Research, vol. 27, iss. 1, e1589, p. 1鈥�10, doi: 10.1002/mpr.1589.

International Research Project

The Observation of Children in Lithuanian Care Homes in Preparation for their Trip and Stay in Italian Carers鈥� Families, Cultural Mediation and Psychological Support for Children and Carers.

The project of the visits is delivered by the not-for-profit organization 鈥淣uovo Cielo鈥� (president Sara Bianci), and is carried out in collaboration with Paolo Sesti (University of Calabria, Italy). The project is ongoing.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Institute of Psychiatry Kings College, London (UK)
Viena S. Freud Private University (Austria)
Department of Child and Adolescent Psychiatry of Heidelberg University (Germany)
91桃色, Faculty of Philosophy (Lithuania)
Lithuanian Academy of Music and Theatre, Faculty of Music (Lithuania)

OTHER SCIENTIFIC ACTIVITIES

Prof. S. Lesinskien臈 鈥�

vice-president of Lithuanian Psychiatric Association;
board Member of Lithuanian Society for Art Therapy Application;
vice president of IACAPAP: International Association for Child and Adolescent Psychiatry and Allied Professions;
board member of NBO: Nornic Baltic Organisation;
editorial board member of the journal Pediatrija (Paediatrics), .

Prof. D. P奴ras 鈥�

UN Special rapporteur on the right to physical and mental health;
Chair ofthe Coordination committee of the Special procedures of the United nations;
University of Essex (UK) visiting professor;
Georgetown University (USA) distinguished visitor;
editorial board member of the national journal Visuomen臈s sveikata (Public Health),
editorial board member of the national journal Medicina;
member of International Advisory Board of the Aarchives of Psychiatry and Psychotherapy,

Prof. A. Germanavi膷ius 鈥�

editorial board member of the journals: Nordic Journal of Psychiatry, Medicina (Medicine), Visuomen臈s sveikata (Public Health), Biologin臈 psichiatrija ir psichofarmakologija (Biological Psychiatry and Psychopharmacology);
scientific board member of the Neuroscience Institute at Lithuanian University of Health sciences (Kaunas);
Executive Board member of ENMESH (European Network for Mental Health Service Evaluation: );
Member of European network on Training, Evaluation and Research (ENTER: );
Representative for Lithuanian Association of Psychiatrist for Nordic Board of World Psychiatric association (WPA).

Assoc. Prof. A. Navickas 鈥�

president of the Lithuanian Association of Suicidology;
president of the Lithuanian Psychiatric Association;
member of International Association of Suicide Prevention;
member of the Committee of Nordic Psychiatric Associations;
member of the Steering Committee of the European Psychiatric Association;
editorial board member of the journal Biologin臈 psichiatrija ir psichofarmakologija (Biological Psychiatry and Psychopharmacology),
editor-in-chief of the journal Psichiatrijos 啪inios (News of Psychiatry);
chair of Organizing Committee of the WPA Inter Zonal Congress in Vilnius;
WPA Honorary Membership for excellence in service to the World Psychiatric Association.

Assoc. Prof. A. 艩iurkut臈 鈥�

editorial board member of the journal Psichiatrija. Mental Health Research Centre Russian Acad.of Med.Sci;
member of Lithuanian Psychiatric Association.

Assoc. Prof. R. Vili奴nien臈 鈥�

president of Lithuanian Society of Psychoanalysis (LPaD),
member of Lithuanian Psychiatric Association (LPA).

Research fellow A. Dervinyte-Bongarzoni 鈥�

member of Lithuanian Psychiatry Association;
member of Children and Adolescents Psychiatry Association.

MOST IMPORTANT RECEIVED NATIONAL AND INTERNATIONAL AWARDS FOR R&D ACTIVITIES

Prof. D. P奴ras - the Order for Merits to Lithuania.

MOST IMPORTANT CASES OF PARTICIPATION OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

S. Lesinskien臈鈥� Participation in the working group elaborating National suicide prevention strategy, set by Ministry of Health in Lithuania.
V. Karaliene 鈥� participation in working group inproving child and adolescent mental health services and regulations, set by Ministry of Health in Lithuania

CONSULTATIONS PROVIDED BY THE UNIT TO THE PUBLIC OR ECONOMIC ENTITIES

Clinic staff often participates in debates or opinion formation regarding mental health and psychiatry initiated by broad variety public media sorces

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

Presentation in the conference held in Lituanian Academy of Science and organized by Ministry of Education and Science and Ministry of Health, 91桃色 etc. made by S. Lesinskien臈 Mental health and related factors
Periodically prof. S. Lesinskien臈 participates with presentations on child adolescent and family mental health issues in scientific-practical conferences for family doctors and pediatricians, seminars for specialists and parents in preschool and school educational institutions.

CLINIC OF RHEUMATOLOGY, ORTHOPEDIC TRAUMA AND RECONSTRUCTIVE SURGERY

2 Santari拧ki懦, LT-08661 Vilnius-21
Tel. 236 5302
E-mail:

Head - Prof. Dr. Irena Butrimien臈

STAFF

Professors: Prof. Dr. I. Butrimien臈, Prof. Habil. Dr. A. Venalis, Prof. Habil. Dr. N. Porvaneckas, Prof. Habil. Dr. K. Vitkus, Prof. V. Uvarovas.
Associate professors: Dr. M. Kocius, Dr. I. 艩atkauskas, Dr. R. Rugien臈, Dr. S. Stropuvien臈, Dr. L. Zabulien臈.
Assistant professors: Dr. D. Miltinien臈, Dr. S. Ryli拧kis, Dr. I. Ar拧tikyt臈.
Lecturer: Dr. N. Jakutis.
Research fellows: Dr. R. Rugien臈, Dr. D. Miltinien臈, G.Stund啪ait臈鈥揃ar拧auskien臈, I.Sakalauskait臈.
Doctoral students: R. 艩akalyt臈, E. Puncevi膷ien臈, E. Tertelien臈, A. Makulavi膷ius, G.Stund啪ait臈-Bar拧auskien臈, A. Petrulionien臈, G. Petryla.
Students鈥� scientific groups of:

Rheumathology: scientific leader 鈥� Dr. D. Povil臈nait臈, coordinator 鈥� student J.Mironova, 15 members of the group.
Orthopaedics and traumatology: scientific leader 鈥� Dr. S. Prof. N. Porvaneckas, coordinator 鈥� student R. Brad奴nait臈; 57 members of the group.

RESEARCH AREAS

Randomized prospective comparison of Achilles tendon open and minimally invasive surgical treatment methods. Biomechanical and anatomical evaluation of tendon stitches
Assessment of quality of life and functional outcomes after pelvic bone trauma

RESEARCH INTERESTS

Peculiarities of applying biological therapy to rheumatic patients in Lithuania
Immunogenicity in rheumatic patients with anti-TNF treatment
Outcomes of early undifferentiated arthritis
Effects of light emitting diodes (LED) in systemic sclerosis patients
Associations between genetic, epigenetic factors, rheumatoid arthritis ethiopathogenesis and clinical course

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Phototherapy in the Animal Models of Systemic Sclerosis. Prof. A. Venalis, PhD student D. Karpec. 2014鈥�2018.

The special-purpose medical device 鈥淚MC-Light鈥� has been constructed during the doctoral studies. The equipment consists of ultraviolet (UVA1) light emitting diodes, which emit the ultraviolet rays with a peak wavelength of 365卤5 nm. Animal models are essential tools in investigating in-depth the search of new therapeutic modalities.
The main objective of the project is to define the efficacy and safety of narrowband ultraviolet (UVA1) for the treatment of dermal fibrosis in bleomycin-induced mouse scleroderma. The results of the study have revealed that narrowband UVA1 phototherapy reduces the dermal thickness, stops the progression of dermal fibrosis, induces the regression of already existing fibrotic changes in the established, bleomycin-induced mouse model of scleroderma. Further experiments concerning the mechanisms of action and safety of narrowband UVA1 phototherapy will be performed.

Main publication:

Karpec, D., Rudys R., Leonaviciene L., Mackiewicz Z., Bradunaite R., Kirdaite G., Venalis A. 2018. The safety and efficacy of light emitting diodes-based ultraviolet A1 phototherapy in bleomycin-induced scleroderma in mice. Advances in Medical Sciences, vol. 63, iss. 1, p. 152鈥�159, doi: 10.1016/j.advms.2017.09.001

Associations Between Genetic, Epigenetic Factors and Rheumatoid Arthritis Ethiopathogenesis and Clinical Course. Prof. I. Butrimien臈, Phd student E. Puncevi膷ien臈. Ongoing since 2015.

Aim of study is to investigate the association between genetic, epigenetic factors in pathogenesis of rheumatoid arthritis, disease activity and clinical course. Special attention will be kept on vitamin D concentration and oral health as external risk factors in higher susceptibility for rheumatic diseases and influence in ethiopathogenesis by causing changes in gene function. Accordingly, research of laboratory data of epigenetics (DNA methylation, ect.) and genetics (vitamin D receptor gene polymorphism) that potentially mediates genetic risk for rheumatoid arthritis will be done. This study is approved by Lithuanian Bioethics Committee.

Significanse of Sociodemographic, Clinical, and Laboratory Parameters Significance for Early Undifferentiated Arthritis Outcomes: Prof. A. Venalis, Phd student R. 艩akalyt臈. 2014鈥�2018.

The main objective of this project is to evaluate the significance of certain clinical, laboratory and sociodemographic parameters, alone or in combination, for the outcomes of early undifferentiated arthritis. The aim of the this study is to find a method that will diagnose chronic inflammatory joint disease as soon as possible, before irreversible joint damage is present and to determine when to start treatment with antirheumatic disease modifying drugs. With partner we plan to evaluate certain single nucleotide polymorphisms (SNPs) influence in pathogenesis of chronic inflammatory arthritis, to see if any of these SNPs are associated with early joint structural damage seen on ultrasound. We will also measure the activity of certain genes, which are responsible in development of autoimmune joint disease during the course of early undifferentiated arthritis.

Main publication:

Stropuvien臈, S., Baranauskait臈, A., Bukauskien臈, L., Zaikauskien臈, J. 2018. The impact of anti-cyclic citrullinated peptide antibody status on the management of patients with early rheumatoid arthritis: observational study results from Lithuania. Acta Med Litu, vol. 25, no 2, p. 112鈥�123, doi: 10.6001/actamedica.v25i2.3765

The Long Term Prognosis of Rheumatoid Arthritis Patients after Knee Arthroplasty in Lithuania. Prof. A. Venalis, PhD student E. Tertelien臈. Ongoing since 2015.

Aim of study is to identify factors that influence the patients functional outcome and quality of life after total knee arthroplasty in Lithuania.
The main objectives of this study are: to evaluate the results of total knee replacement in rheumatic patients 2 years after surgery; to identify factors that influence implant survival, complications rate and risk factors for revision surgery; to validate Lithuanian Arthroplasty database with respect to revisions recorded and to identify conservatively treated or untreated infected patients. This study is approved by Lithuanian Bioethics Committee.

Lyme Disease and Rheumatic Symptoms: Epidemiological and Clinical Interface with a Transmitter of Disease and Biological Characteristics of thePathogen. Prof. A. Venalis, PhD student A. Petrulionien臈. Since 2016, ongoing.

The main objective of the project is to determine correlations between infected ticks with different genotypes of Borrelia burgdorferi (B.b.) in different regions of Lithuania, Lyme鈥檚 disease, immunoglobulin and clinical course in order to forecast the clinical way of disease according to B.b. genotype. This study is approved by Vilnius Regional Bioethics Committee, and by State Data Protections Inspectorate. Co-working with Center for Communicable Diseases and AIDS the database of patients who had Lyme didsease in 2014鈥�2016 years in Lithuania was created A retrospective analysis of the data of patients who were treated in the Infectious disease center (91桃色, Santaros clinics) because of Lyme disease was performed.

Biologic Therapy in Patients with Autoimmune Arthritis in Lithuania. Prof. I. Butrimien臈, Dr. I. Ar拧tikyt臈. 2007鈥�2018.

By December 2018, information was collected and recorded from 947 patients with rheumatoid arthritis, ankylosing spondilitis, psoriatic arthritis and juvenile idiopathic arthritis treated with biologics; over 6600 questionnaires in total. The peculiarities of applying biological therapy to rheumatic patients in Lithuania concerning lower drugs dosages, treatment efficacy and adverse event profile are analyzed. Patients treated with anti-TNF blockers are investigated for the concentration of medication and antibodies to the drug (total 240 patients).

EMerging EUlar NETwork (EMEUNET). Coordinnator 鈥� PhD sutent G. 艩e拧kut臈, since 2013.

Goda 艩e拧kut臈 is a working group member and country liaison of EMEUNET (a working group of young clinicians and researchers in rheumatology). The objectives of the organization are to promote education, perform research, widen collaborations and integrate with EULAR activities. Goda 艩e拧kut臈 as country liaison is responsible for disseminating and promoting information amongst young clinicians and scientists within the country. G. 艩e拧kut臈 collected data from Lithuania rheumatology trainees.

Access to Social Security Benefits in Case of Work Disability Due to RA. Coordinator: Polina Putrik. Prof. I. Butrimien臈. The Research team at Maastricht University initiated the project since 2016.

The aim of this study is to compare the differences in access to social security benefits in case of sick leave and work disability and to compare the level on income substitution and lower economic status for patients with rheumatoid arthritis in different countries across Europe. 43 countries take part in the project.

Clinical, Psychosomatic and Radiologic Peri- And Postoperative Evaluation of Axial Skeleton and Joint Degenerative Diseases. Prof. N. Porvaneckas. 2014鈥�2018.

Total knee arthroplasty 鈥� the influence of preoperative patient factors on pain, function and quality of life. A prospective randomized study of minimally invasive treatment of acute Achilles tendon rupture. A prospective study of functional outcomes after pelvic ring ant acetabulum fracture treatment. Comparison of three tourniquet application methods in primary total knee arthroplasty surgery. The protocol was approved by the Regional Ethical Committee and registered at Clinicaltrials.gov (identifier: NCT01355900).

A Prospective Randomized Study of Minimally Invasive Treatment of Acute Achilles Tendon Rupture. January 2015鈥揇ecember 2019.

The protocol was approved by the Regional Ethical Committee. A prospective study of functional outcomes after pelvic ring and acetabulum fracture treatment is ongoing.

National Research Projects

Research Council of Lithuania. Analysis of Immunological, Genetic and Epigenetic Factors in Pathogenesis of Autoimmune Arthritis. (No. S-MIP-17-12). Prof. I. Butrimien臈. 2017鈥�2020.

The aim of this study is to determine corelation of immunologic, genetic, and epigenetic factors (expression of Toll-like receptors, vitamin D response metabolism genes DNA sequence methylation changes, vitamin D receptors genes polymorphisms) on ethiopathogenesis of autoimmune arthritis.
It is planned to investigate approximately 220 patients with autoimmune arthritis and approximately 180 healthy controls, will carry out genetic and approximately for 100 subjects (50 patients/50 control group) epigenetic vitamin D metabolism genes analysis. Later we will examine synovial tissues and vitamin D levels in blood sera in 30 patients. These patients will consist of three groups: early arthritis, rheumatoid arthritis, and osteoarthritis patients (10 from each group). In each group we will measure the level of Toll-like receptors and their ligands expression. These molecular mechanisms will be linked with autoimmune disease severity, vitamin D level, and its metabolisms efficiency.

International Research Projects

The EULAR Scleroderma Trials and Research group (EUSTAR) initiated multicentral online study Minimum Essential Data Set. Since 2011. Cordinator: Walker, Ulrich A. University Basel, Dr. Rugelien臈.

Minimal essential data set (MEDS) Online is an international registry established by the European League against Rheumatism scleroderma trial and research (EUSTAR), which collects data from over 8000 patients from 92 centres worldwide, including 21 European centres and 9 centres outside Europe. Center contribution: clinical patient data input online, updated on an annual basis.

Genetic Analysis of Early Undifferentiated Arthritis Patients (single nucleotide polymorphism profile) Association with Disease Outcome and Early Radiological and Ultrasound Damage. Partner Children鈥檚 Hospital Oakland Research Institute, California, USA, PhD Damini Jawaheer. 2016鈥�2019. R. Sakalyte.

The aim of this study is to evaluate if any single nucleotide polymorphism (SNP) alone or in combination can help to predict the outcomes comes of early undifferentiated arthritis. Moreover, we want to see if any of SNP we analyse are related with early joints damage (erosions) that can be detected on ultrasound. All this could help to determine which early undifferentiated arthritis patients should be treated more aggressively to prevent debilitating outcomes of arthritis.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Department of Clinical Science and Education, Karolinska Institutet S枚dersjukhuset Section of Anaesthesiology and Intensive Care, Stockholm (Sweden)
Department of Quantum Electronics of the Faculty of Physics of 91桃色 (Lithuania)
State Research Institute Centre for Innovative Medicine (Lithuania)
The EULAR Scleroderma Trials and Research group (Italy)
The European League against Rheumatism (Switzerland)
Children鈥檚 Hospital Okland Research Institute, San Francisco (USA)

OTHER SCIENTIFIC ACTIVITIES

Prof. I. Butrimien臈 鈥�

board member of Opinion Leaders for Biological Therapy, Europe;
member of executive committee for clinical trials in European League against Rheumatism;
president of Lithuanian Arthritis Foundation;
member of the Lithuanian Rheumatology Association;
editorial board member of the journals Reumatologijos seminarai (Seminars in Rheumatology) and Skausmo medicina (Pain Medicine);
co-president of the organizing committee of annual conference Vilnius Rheumatology Seminars.

Prof. A. Venalis 鈥�

board member of European League against Rheumatis;
member of executive committee for clinical trials in European League against Rheumatism;
member of the Lithuanian Rheumatology Association;
editorial board member of the journals Reumatologijos seminarai (Seminars in Rheumatology);
co-president of the organizing committee of annual conference Vilnius Rheumatology Seminars;
editorial board member of the journal Rheumatology (Poland).

Prof. N. Porvaneckas 鈥�

editorial board member of the journal Medicina;
editorial board member of the journal Medicinos teorija ir praktika (Theory and Practice in Medicine);
board member of the Lithuanian Orthopaedic and Trauma Society;
member of EFFORT, European Hip Society and AO.

Assoc. Prof. S. Stropuvien臈 鈥�

delegate member of EULAR Standing Committee on Education and Training (ESCET);
editorial board member of the journal Reumatologijos seminarai (Seminars in Rheumatology);
acting secretary of the Lithuanian Rheumatology Association.

Assoc. Prof. R. Rugien臈 鈥�

editorial board member of the journals Reumatologijos seminarai (Seminars in Rheumatology);
organizing committee member of the annual conference Vilnius Rheumatology Seminars;
member of The EULAR Scleroderma Trials and Research Group (EUSTAR);
member of the Lithuanian Rheumatology Association.

Assoc. Prof. M. Kocius 鈥�

editorial board member of the journal Medicinos teorija ir praktika (Theory and Practice in Medicine);
member of EFFORT.

Assist. Prof. I. Ar拧tikyt臈 鈥�

member of Emerging Eular Network (EMEUNET) - The European League Against Rheumatism (EULAR) working group of young clinicians and researchers in rheumatology;
organizing committee member of the annual conference Vilnius Rheumatology Seminars;
member of the Lithuanian Rheumatology Association.

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

Participation in patient鈥檚 organisation 鈥淟ietuvos Artrito Asociacija鈥� (Lithuanian Arthritis Association), 鈥淟UPUS鈥�, and 鈥淛udesys鈥� activities.
Articles presented to journals Internistas, Medicinos teorija ir praktika, pacients鈥� journal Artritas, participation in TV and radio programs.

CLINIC OF CARDIOVASCULAR DISEASES

2 Santari拧ki懦, LT-08661 Vilnius
Tel. 236 5307
E-mail

Head 鈥� Prof. Habil. Dr. Aleksandras Laucevi膷ius

STAFF

Professors: Dr. A. Aidietis, Dr. J. 膶elutkien臈, Dr. G. Davidavi膷ius (part-time), Dr. A. Kibarskis, Dr. G. Marinskis, Dr. 沤. Petrulionien臈, Dr. K. Ru膷inskas, Dr. P. 艩erpytis, Dr. V. Tarutis, Dr. D. Zakarkait臈 (part-time).
Associate professors: Dr. S. Aidietien臈, Dr. J. Barysien臈, Dr. S. Glaveckait臈, Dr. G. Kalinauskas, Dr. R. Karalius, Dr. B. Petrauskien臈, Dr. A. Rudys, Dr. J. Badarien臈.
Lecturers: Dr. J. Misi奴ra, Dr. R.S. Samalavi膷ius, Dr. R. Vaitkevi膷ius (part-time), D. Sudavi膷ien臈 (part-time), Dr. G.L. Vilkevi膷ius, Dr. R. K奴gien臈 (part-time), Dr. B. Vai拧nyt臈.
Assistants: Dr. R. Stepon臈nien臈, Dr., Dr. N. Misonis (part-time), Dr. V. Janu拧auskas, Dr. R. Sipavi膷ius.
Research fellows: J. Balsyt臈 (part-time), Dr. A. Baranauskas, Dr. A. Ber奴k拧tis, Dr. L. Bezu拧ka, Dr. G. Burneikait臈 (part-time), Dr. I. Butkuvien臈, Dr. A. 膶ypien臈 (part-time), Dr. R. 膶ypien臈, Dr. V. Grabauskien臈, Dr. L. Gumbien臈, Dr. V. Janu拧auskas, Dr. L. Jurgauskien臈, Dr. V. Lebetkevi膷ius, Dr. D. Liekien臈, Dr. A. Lipnevi膷ius, E. Lycholip (part-time), Dr. R. Malickait臈, Dr. V.V. Maneikien臈 (part-time), Dr. N. Misonis (part-time), Dr. R. Navickas (part-time), E. Palevi膷i奴t臈 (part-time), R. Puronait臈 (part-time), Dr. G. Ra膷kauskas (part-time), Dr. E. Rink奴nien臈 (part-time), Dr. L. Ryli拧kyt臈, Dr. P. Sem臈nien臈, Dr. R. Sudikien臈, (part-time), Dr. E. U啪davinyt臈-Gatelien臈 (part-time), Dr. A. Valaika, A. Zorinas (part-time), Dr. G. Zuozien臈 (part-time).
Doctoral students: G. Bal膷i奴nait臈, T. Baltr奴nas, G. Bieliauskien臈, M. Budra, E. 膶iburien臈, A. Dr膮sutien臈, D. Fomin, E. Gai啪auskas, J. Jara拧奴nas, K. Jonas, V. Juknevi膷ius, V. Rudien臈, R. Ruseckait臈, A. Skreb奴nas, E. Stanevi膷i奴t臈, R. 艩erpytis, V. 艩ileikien臈, J. Balsyt臈, E. Palevi膷i奴t臈, A. Podkopajev, G. Radauskait臈.
Scientific groups of students:
Cardiology: scientific leader 鈥� Prof. P. 艩erpytis, coordinator 鈥� student M. Kazlauskait臈; 87 members of students.
Cardiac surgery: scientific leader 鈥� Prof. V. Tarutis, coordinator 鈥� student J. 艩niauk拧ta; 12 members of students.
Emergency medicine: scientific leader 鈥� Dr. R. Samalavi膷ius, coordinator 鈥� student D. Petru拧yt臈; 80 members of students.
Vascular surgery: scientific leader 鈥� A. Skreb奴nas, coordinator 鈥� student K.E. Navardauskait臈; 22 members of students.

RESEARCH INTERESTS

Investigation of arterial wall functional and structural disorders in atherosclerosis and metabolic syndrome
Primary and secondary prevention of cardiovascular diseases
Development of high-risk strategy in prevention of cardiovascular diseases
Fundamental and clinical research in cardiac arrhythmias
Improvement of methods of complex treatment of atrial and ventricular tachyarrhythmia
Complex multi imaging assessment of left and right ventricular function in coronary artery disease, hypertension and heart failure
Myocardial regeneration therapy by cardiac pulse wave therapy in coronary heart disease
Congenital heart disease cardiac surgery in infants
New possibilities of hybrid (interventional and surgical) and minimally invasive technologies in cardiovascular medicine

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

OInduced Diseases. Prof. A. Laucevi膷ius. 2014鈥�2019.

During the 2018, we aimed to investigate the possibility to uncover the early phase of HFpEF (heart failure with preserved ejection fraction) by means of exercise capacity evaluation and biomarker testing in metabolic syndrome population using a combination of B type Natriuretic Peptide (BNP) and peak VO2. Enrolled individuals with MetS demonstrated reduced exercise capacity and/or elevated BNP consistent with the early signs of HFpEF. The analysis of arterial markers in the prospective group revealed statistically significant association of AIxHR75 with early phase of HFpEF. We referred patients with resistant hypertension who cannot achieve normal blood pressure values after medical treatment correction for renal artery denervation. We also perform follow-up after procedure and investigated predictive biomarkers for the long-term effect and quality of the procedure. In addition, we evaluated cardiovascular risk profile in dyslipidemic middle-aged men and women over the period 2009-2016. We investigate the importance of LDL-C and TG levels assessment for FH screening in the middle-aged Lithuanian adults.

Main publications:

Kutkien臈 S., Petrulionien臈沤., Laucevi膷ius A., 膶erkauskien臈 R., Staigyt臈 J., 艩aulyt臈 A., Petrulionyt臈 E., Gargalskait臈 U., Skiauteryt臈 E., Matuzevi膷ien臈 G., Kovait臈 M., Rink奴nien臈 E. 2018. Lipid pro铿乴e evaluation and severe hypercholesterolaemia screening in the middle-aged population according to nationwide primary prevention programme in Lithuania. Atherosclerosis, vol. 277, p. 267鈥�272.

Petrulionien臈沤., Gargalskait臈 U., Kutkien臈 S., Staigyt臈 J., 膶erkauskien臈 R., Laucevi膷ius A. 2018. Establishing a national screening programme for familial hypercholesterolaemia in Lithuania. Atherosclerosis, vol. 277, p. 407鈥�412.

De Bacquer D., De Smedt D., Kotseva K., Jennings C., Wood D., Ryd茅n L., Gyberg V., Shahim B., Amouyel P., Bruthans J., Castro Conde A., C铆fkov谩 R., Deckers J.W., De Sutter J., Dilic M., Dolzhenko M., Erglis A., Fras Z., Gaita D., Gotcheva N., Goudevenos J., Heuschmann P., Laucevi膷ius A., Lehto S., Lovic D., Mili膷i膰 D., Moore D., Nicolaides E., Oganov R, Pajak A., Pogosova N., Reiner Z., Stagmo M., St枚rk S., Tokg枚zo臒lu L., Vulic D., Wagner M., De Backer G., EUROASPIRE Investigators. 2018. Incidence of cardiovascular events in patients with stabilized coronary heart disease: the EUROASPIRE IV follow-up study. European Journal of Epidemiology, doi: 10.1007/s10654-018-0454-0. IF 7.023.

New Technologies for Management of Structural Heart Diseases and Arrhythmias. Prof. Dr. A. Aidietis, Prof. Dr. K. Ru膷inskas. 2014鈥�2019.

Since 2011, at VUHSK 98 patients with degenerative mitral valve regurgitatant pathology we treated in the transapical off-pump fashion with Neochord Implantation using NeoChord DS1000 system (NeoChord, Inc., Eden Praire, MN). In 2018, nine patients underwent this procedure. On the basis of the collected data doctoral dissertation is being prepared.
Since 2005 at VUHSK 94 patients were treated for mitral valve paravalvular leak. Forty-nine patients underwent conventional redo surgery, while 40 patients underwent surgical transapical catheter based mitral paravalvular leak closure with a closure device. In 2018, there were 6 patients who underwent this procedure. The international paravalvular leak Registry has been joined. On the basis of the collected data doctoral dissertation was defended.

Main publications:

Colli A., Manzan E., Aidietis A., Rucinskas K., Bizzotto E., Besola L., Pradegan N., Pittarello D., Janusauskas V., Zakarkaite D., Dr膮sutiene A., Lipnevicius A., Danner B.C., Sievert H., Vaskelyte L., Schnelle N., Salizzoni S., Marro M., Rinaldi M., Kurnicka K., Wrobel K., Ceffarelli M., Savini C., Pacini D., Gerosa G. 2018. An early European experience with transapical off-pump mitral valve repair with NeoChord implantation. European Journal of Cardio-thoracic Surgery, vol. 54, no 3, p. 460鈥�466, doi 10.1093/ejcts/ezy064 IF 3,759

Zorinas A., Janusauskas V., Davidavicius G., Simakauskas R., Puodziukaite L., Zakarkaite D., Bilkis V., Cypiene R. Samalavicius R., Onorato E., Aidietis A., Rucinskas K. 2018. Retrospective analysis of a single centre early and midterm results of the transapical catheter-based mitral paravalvular leak closure with a purpose specific device. Postepy w Kardiologii Interwencyjnej (Advances in Interventional Cardiology), vol. 14, no 2, p. 167鈥�175, doi:

Samalavi膷ius, R.S., Norkiene, I., Dr膮sutiene, A., Lipnevicius, A., Janusauskas, V., Urbonas, K., Zakaraite, D., Aidietis, A., Rucinskas, K. 2018. Aesthetic management and procedural outcomes of patients undergoing off-pump transapical implantation of artificial chordae to correct ritral Regurgitation: case series of 76 patients. Anesthesia and Analgesia, vol. 126, no 3, p. 776鈥�784, doi: 10.1213/ANE.0000000000002767.

Improvement and Evaluation of Congenital Heart Disease Surgery. Prof. Dr. V. Tarutis. 2014鈥�2019.

A review of the heart transplantation in children in Lithuania was presented in a 30 years for Heart Transplantation in Lithuania congress of the Lithuanian Society of Thoracic and Heart Surgery. Presentation 39 years of experience of treating transposition of the great arteries in a single low-volume center was made at the 7th World Congress of Pediatric Cardiology and Cardiac Surgery in Barcelona. An article 30-year experience of Fontan surgery: single-centre鈥檚 data was published in the Journal of Cardiothoracic Surgery. Our experience in a surgical treatment of pulmonary artery valve endocarditis was summarized and an article prepared.

Main publications:

Rudien臈, V., Glaveckait臈, S., Zakarkait臈, D., Gumbien臈, L., Aidietis, A. 2018. Cor triatriatum sinistrum with obstruction: a rare presentation in an adult. Acta medica Lituanica, vol. 25, suppl., 75.

Jonas, K., Jakutis, V., Sudikien臈, R., Lebetkevi膷ius, V., Tarutis, V. 2018. Transposition of the great arteries: the evolution of treatment in a single low-case. Acta medica Lituanica, vol. 25, suppl., 32.

Optimization of Diagnosis and the Creation of Treatment Strategy for Type 2 Myocardial Infarction. Prof. P. 艩erpytis.

The aim of this study is to improve the diagnosis of type 2 MI, to evaluate the benefits of new laboratory and instrumental investigations and to evaluate different patient treatment strategies. Based on our data, this randomized study will be analyzing a wide range of diagnostic tests and treatment strategies. It is the first randomized study of its kind in Lithuania and in the world.

Efficacy of Extracorporeal Shockwave Myocardial Revascularization in Patients with Stable Angina. Prof. A. Laucevi膷ius, Prof. J. 膶elutkien臈, Dr. G. Zuozien臈, Dr. G. Burneikait臈, Dr. I. Butkuvien臈.

A multicentre randomized triple-blind sham-procedure controlled study of cardiac shock wave terapy was performed. The study size 鈥� 72 patients, endpoints 鈥� exercise capacity assessed by the total treadmill test duration, time until the occurrence of ECG changes, angina class, consumption of antianginal medications. The endpoints of the imaging substudy were peak wall motion score during dobutamine stress echocardiography and summed difference score of myocardial perfusion scintigraphy.

Main publications:

Shkolnik E., Burneikait臈 G., 膶elutkien臈 J., Scherbak M., Zuozien臈 G., Petrauskien臈 B., Trush E., Laucevi膷ius A., Vasyuk Y. 2018. Efficacy of cardiac shock wave therapy in patients with stable angina: The design of randomized, triple blind, sham-procedure controlled study. Anatolian Journal of Cardiology, vol. 19, iss. 2, p. 100鈥�109, doi: 10.14744/AnatolJCardiol.2017.8023.

Shkolnik E., Burneikait臈 G., Jakutis G., Scherbak M., Zuozien臈 G., Petrauskien臈 B., Trush E., Vasyuk Y., Laucevi膷ius A., 膶elutkien臈 J. 2018. A randomized, triple-blind trial of cardiac shock-wave therapy on exercise tolerance and symptoms in patients with stable angina pectoris. Coronary Artery Disease, vol. 29, no 7, p. 579鈥�586, doi: 10.1097/MCA.0000000000000648.

National Research Projects

Research Council of Lithuania Project

The National Lithuanian studies development programme for 2016-2024 Healthy Ageing. Cardiometabolic Early Vascular Aging Determinants (SEN 鈥� 03/2016). Prof. A. Laucevi膷ius. 2016鈥�2018.

One of the most important tasks of the modern preventative medicine is to highlight people having high cardiovascular (CV) risk prior to an event and applie the wright measures to avoid or considerably postpone it. Therefore, the aim of our study was to examine the dynamics of early cardiovascular aging and metabolic syndrome factors, and their interaction. After analysis of all the data we collected we arrived to a conclusion, that none of currently widely used risk assessment tools (Reynolds, FRS, FRS2, ATP-III, IAS-AGLA, PROCAM and SCORE) are suited for assessing risk for ever increasing metabolic syndrome patient group. We have also analysed additional data regarding arterial stiffness defined by aortic pulse wave velocity (PWV). Analysis shows that PWV ability to predict CV diseases is valid, thus PWV measures should be included in CV risk assessment tools, and not used in isolation.

Main publications:

Slivovskaja, I., Ryli拧kyt臈, L., 艩erpytis, P., Navickas, R., Badarien臈, J., 膶elutkien臈, J., Puronait臈, R., Ryli拧kien臈, K., 膶ypien臈, A., Rink奴nien臈, E., 艩ileikien臈, V., Petrauskien臈, B., Juocevi膷ius, A., Laucevi膷ius, A. 2018. Aerobic training effect on arterial stiffness in metabolic syndrome. The American Journal of Medicine, vol. 131, no 2, p. 148鈥�155, doi: 10.1016/j.amjmed.2017.07.038.

Jakutis G., Juknevi膷ius V., Barysien臈 J., Mata膷i奴nien臈 D., Petrauskien臈 B., Petrulionien臈沤., Laucevi膷ius A. 2018. A rare case of REM sleep-related bradyarrhythmia syndrome with concomitant severe hypertension: a case report and a review of literature. Acta Medica Lituanica, vol. 25, no 1, p. 1鈥�6, doi: 10.6001/actamedica.v25i1.3697

Diagnostic and Prognostic Value of Biomarkers for Patients Hospitalised due to Acute Heart Failure: Prospective Observational Multicenter Cohort Study (MIP 049/2015). 2015鈥�2018. Project leader 鈥� Prof. Dr. J. 膶elutkien臈.

The association of the readmissions during first 6 months after discharge with 1-year mortality was analyzed. Next ongoing analyses are the prognostic value of novel biomarker GDF-15 for hard outcomes of acute dyspnea patients and the significance of right ventricular deformation indices for morbidity and mortality of acute heart failure and non- acute heart failure patients.

Main publications:

Doehner W., Ural D., Haeusler K.G., 膶elutkien臈 J., Bestetti R., Cavusoglu Y., Pe帽a-Duque M.A., Glavas D., Iacoviello M., Laufs U., Alvear R.M., Mbakwem A., Piepoli M.F., Rosen S.D., Tsivgoulis G., Vitale C., Yilmaz M.B., Anker S.D., Filippatos G., Seferovic P., Coats A.J.S., Ruschitzka F. 2018. Heart and brain interaction in patients with heart failure: overview and proposal for a taxonomy. A position paper from the Study Group on Heart and Brain Interaction of the Heart Failure Association. European Journal of Heart Failure, vol. 20, iss. 2, p. 199鈥�215, doi: 10.1002/ejhf.1100.

Slivovskaja I., Ryli拧kyt臈 L, 艩erpytis P., Navickas R., Badarien臈 J., 膶elutkien臈 J., Puronait臈 R., Ryli拧kien臈 K., 膶ypien臈 A., Rink奴nien臈 E., 艩ileikien臈 V., Petrauskien臈 B., Juocevi膷ius A., Laucevi膷ius A. 2018. Aerobic training effect on arterial stiffness in metabolic syndrome. The American Journal of Medicine, vol. 131, no 2, p. 148鈥�155, doi: 10.1016/j.amjmed.2017.07.038.

Akiyama E., Van Aelst L.N.L, Arrigo M., Lassus J., Mir贸脪., 膶elutkien臈 J., Choi D.J., Cohen-Solal A., Ishihara S., Kajimoto K., Laribi S., Maggioni A.P., Motiej奴nait臈 J., Mueller C., Parenica J., Park J.J., Sato N., Spinar J., Zhang J., Zhang Y., Kimura K., Tamura K., Gayat E., Mebazaa A; GREAT (Global Research on Acute Conditions Team) Network. 2018. East Asia may have a better 1-year survival following an acute heart failure episode compared with Europe: results from an international observational cohort. European Journal of Heart Failure, vol. 20, no. 6, p. 1071鈥�1075, doi: 10.1002/ejhf.1152.

International Research Project

Research project User Driven Innovation: Symptom Monitoring after Hospitalization in Patients with Advanced Heart Failure: A Nordicbaltic Study (Project No.: 76015). Leader of national group Prof. J. 膶elutkien臈.

Non-invasive lung impedance monitors and Actigraph devices (registering physical activity) are acquired from Cardioset Company. Feasibility study of home measurements performed in two centers (Lithuania and Norway), 10 patients after discharge are recruited. Data on everyday symptoms, lung impedance and physical activity during 30 days are collected for analysis.

Main publications:

Lycholip E., Aamodt I.T., Lie I., 艩imbelyt臈 T., Puronait臈 R., Hillege H., de Vries A., Kraai I., Stromberg A., Jaarsma T., 膶elutkien臈 J. 2018. The dynamics of self-care in the course of heart failure management: data from the IN TOUCH study. Patient Preference and Adherence, vol. 12, no 2, p. 1113鈥�1122.

Grigali奴nas G., Lycholip E., Burneikaite G.,藱Grigaliuniene A., Kaklauskaite G., Romualdas Maci奴unas R., Balci奴unas M., Steponeniene R., Kavoliuniene A., Celutkien臈, J., St枚rk S. 2018. Heart failure awareness: a cross-sectional study on misconceptions and educational opportunities. Seminars in Cardiovascular Medicine, vol 24, p. 9鈥�15, doi:

CULPRIT-SHOCK ClinicalTrials. Gov number NCT01927549. Funded by the European Union 7th Framework Program and others. Multivessel Versus Culprit Lesion only Percutaneous Revascularization in Patients with Acute Myocardial Infarction Complicated by Cardiogenic Shock, leader of national group Prof. P. 艩erpytis. 2014鈥�2018.

The CULPRIT-SHOCK trial is the largest randomized clinical trial in cardiogenic shock complicating myocardial infarction (62% STEMI) to date comparing IRA-only PCI with immediate PCI of all severe lesions. The CULPRIT-SHOCK trial addressed a contemporary, very high-risk patient population.
From April 2013 through April 2017, a total of 1075 patients with cardiogenic shock were screened at 83 European centers, and 706 of those patients (65.6%) were randomly assigned to the culprit-lesion-only PCI group (351 patients) or the multivessel PCI group (355 patients).

Main publication:

Thiele H., Akin I., Sandri M., Fuernau G., de Waha S., Meyer-Saraei R., Nordbeck P., Geisler T., Landmesser U., Skurk C., Fach A., Lapp H., Piek J.J., Noc M., Goslar T., Felix S.B., Maier L.S., Stepinska J., Oldroyd K., 艩erpytis P., Montalescot G., Barthelemy O., Huber K., Windecker S., Savonitto S., Torremante P., Vrints C., Schneider S., Desch S., Zeymer U. 2018. One-year outcomes after PCI strategies in cardiogenic shock. New England Journal of Medicine, vol. 379, no. 18, p. 1699鈥�1710, doi: 10.1056/NEJMoa1808788.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Ghent University Hospital, Ghent (Belgium)
Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht (the Netherlands)
Southampton University Hospital, Wessex Cardiothoracic Centre (England)
The Department of Cardiothoracic Surgery, University of Pittsburgh Physicians, Pittsburgh (USA)

OTHER SCIENTIFIC ACTIVITIES

Prof. Habil. Dr. A. Laucevi膷ius 鈥�

member of American College of Cardiology (FACC);
fellow of the European Society of Cardiology (FESC);
member and fellow of North American Society of Pacing and Electrophysiology (NASPE);
member of the Lithuanian Academy of Sciences;
member of the Council of the Faculty of Medicine of 91桃色;
member of the Lithuanian Society of Cardiology;
editorial board member of the journal Medicina (Lithuania);
managing editor of the journal Seminars in Cardiovascular Medicine;
editorial board member of the journal Internistas (Internist);
editorial board member of the journal Mediterranean Journal of Pacing and Electrophysiology (MESPE);
editorial board member of the journal Journal of Human Hypertension;
international editorial board member of the journal Europace (ESC);
editorial board member of the journal Blood Pressure;
editorial board member of the journal Cardiology Management, editorial board member of the journal Cardiology Journal (Folia Cardiologica);
chair of the Doctoral Committee of the Faculty of Medicine.

Prof. Dr. A. Aidietis 鈥�

board member of Lithuanian Heart Association;
chairman of Heart Rhythm workgroup at Lithuanian Society of Cardiology;
member of Lithuanian Society of Thoracic and Cardiac Surgeons;
member of Scandinavian Association for Thoracic Surgery;
editorial board member of the journal Seminars in Cardiovascular Medicine.

Prof. Dr. J. 膶elutkien臈 鈥�

member of Lithuanian Society of Cardiology;
Elect President of Lithuanian Society of Cardiology;
member of Lithuanian Heart Association;
member of European Society of Cardiology;
member of Heart Failure Association of the ESC;
member of European Association of Echocardiography;
Head of Heart Failure working group of Lithuanian Society of Cardiology;
fellow of the European Society of Cardiology;
board member of the Heart Failure Association of the ESC;
member of American College of Cardiology (FACC).

Prof. Dr. G. Davidavi膷ius 鈥�

member of Lithuanian Association for Interventional Cardiology;
European Society of Cardiology TransCatheter Valve treatment (TCVT) Registry Steering Committee member.

Prof. Dr. V. Grabauskien臈 鈥�

national coordinator of Euro Heart Survey Programme (ESC);
fellow of the European Society of Cardiology (FESC);
member of the European Association of Echocardiography (EAE) of the ESC;
member of the Heart Failure Association (HFA) of the ESC;
member of the American Society of Echocardiography;
UEMS (European Union of Medical Specialist) Diploma of European Cardiologist Nr.52546;
member of the European Association for Predictive, Preventive and Personalized Medicine (EPMA);
member of Lithuanian Society of Thoracic and Cardiac Surgeons.

Prof. Dr. A. Kibarskis 鈥�

vice-president of Baltic Association of Interventional Cardiology;
editorial board member of the journal Gydymo menas (Art of Treatment);
editorial board member of the journal Medicinos teorija ir praktika (Theory and Practice in Medicine).

Prof. Dr. G. Marinskis 鈥�

editor-in-Chief of the journal Seminars in Cardiovascular Medicine;
member of the Credentials Committee;
member of Fellowship Committee of the European Society of Cardiology;
member of Nomination Committee of European Heart Rhythm Association;
board member of Lithuanian Heart Association;
Chairman of Heart Rhythm workgroup at Lithuanian Society of Cardiology.

Prof. Dr. 沤. Petrulionien臈 鈥�

editorial board member of the journal Seminars in Cardiovascular Medicine;
editor of chapter Cardiologic Seminars of the journal Internistas (Internist);
member of the European Society of Cardiology;
Chairman of Prevention and Rehabilitation workgroup at Lithuanian Society of Cardiology.

Prof. Dr. K. Ru膷inskas 鈥�

member of European Association for Cardio-Thoracic Surgery;
member of Scandinavian Association for Thoracic Surgery;
board member of Lithuanian Society of Thoracic and Cardiac Surgeons;
editorial board member of the journal Lietuvos chirurgija (Lithuanian Surgery).

Prof. Dr. P. 艩erpytis 鈥�

fellow of the European Society of Cardiology;
chairman of Intensive Cardiac Care workgroup at Lithuanian Society of Cardiology;
member of Lithuanian Heart Association;
member of Lithuanian Society of Cardiology;
expert of Lithuanian Research Council;
editorial board member of the journal Sveikatos mokslai;
scientific board member of the journal Emergency Medicine Service;
editorial board member of the journal International Heart and Vascular Disease Journal.

Prof. Dr. V. Tarutis 鈥�

member of Scandinavian Association for Thoracic Surgery;
board member of Lithuanian Society of Thoracic and Cardiac Surgeons;
editorial board member of the journal Lietuvos chirurgija (Lithuanian Surgery).

Associate Prof. Dr. A. Aidietien臈 鈥�

member of the European Society of Cardiology;
board member of Lithuanian Heart Association;
member of Lithuanian Society of Cardiology.

Associate Prof. Dr. S. Glaveckait臈 鈥�

Member of European Society of Cardiology for Valvular Heart Diseases and Cardiovascular Magnetic Resonance working groups;
Chairman of imaging workgroup at Lithuanian Society of Cardiology;
members of Lithuanian Heart Association.

Associate Prof. Dr. G. Kalinauskas 鈥�

member of European Association for Cardio-Thoracic Surgery;
member of Scandinavian Association for Thoracic Surgery;
President of Lithuanian Society of Thoracic and Cardiac Surgeons;
Chairman of Cardiac Surgery workgroup at Lithuanian Society of Cardiology.

Associate Prof. Dr. R. Karalius 鈥�

member of the European Society for Cardiovascular Surgery;
member of Scandinavian Association for Thoracic Surgery;
member of Lithuanian Society of Thoracic and Cardiac Surgeons;
member of the Society of Lithuanian Surgeons;
member of the Society of Cardiology of Lithuania.

Dr. L. Gumbien臈 鈥�

board member of the Lithuanian Society of Paediatric Cardiology;
chairman of Pulmonary Artery Hypertension and Congenital Heart Disease for Adults workgroup at Lithuanian Society of Cardiology;
member of European Society of Cardiology;
member of Lithuanian Heart Association.

Dr. L. Jurgauskien臈 鈥�

member of European Respiratory Society;
member of European Federation for Immunogenetics;
member of Baltic Sea Society for Immunology;
member of Lithuanian Society for Immunology;
member of Lithuanian Society of Laboratory Medicine;
member of Lithuanian Respiratory Society;
member of Lithuanian Rheumatology Association.

Dr. D. Liekien臈 鈥�

member of the Lithuanian Society of Paediatric Cardiology

Dr. R. Malickait臈 鈥�

member of European Federation for Immunogenetics;
member of International Society for Heart and Lung Transplantation;
board member of Lithuanian Society for Immunology;
board member of Lithuanian Society for Alergology and Clinical Immunology;
members of Lithuanian Society of Thoracic and Cardiac Surgeons;
member of the Lithuanian Society of Laboratory Medicine;
member of Lithuanian Association of Transplantology.

Dr. J. Misi奴ra 鈥�

member of Lithuanian Society of Thoracic and Cardiac Surgeons;
member of the ESC Working Group of Heart Failure.

Dr. R. S. Samalavi膷ius 鈥�

board member of European Association of Cardiothoracic Anesthesiologists;
board member of Lithuanian Society of Thoracic and Cardiac Surgeons;
member of Lithuanian Society of Anaesthesiology and Intensive Care;
editorial board member of the journal Lietuvos chirurgija (Lithuanian Surgery).

Dr. B. Vai拧nyt臈 鈥�

members of Lithuanian Society of Vascular Surgery;
members of Society of Vilnius surgeons;
members of Lithuanian Society of Surgeons.

Dr. A. Valaika 鈥�

board member of Lithuanian Society of Thoracic and Cardiac Surgeons.

Dr. G. Vilkevi膷ius 鈥�

editorial board member of the journal Flebologija;
member of European Federation of Societies for Ultrasound in Medicine and Biology;
member of Lithuanian Society for Vascular Surgery;
vice-president of Lithuanian Society for Phlebology;
member of Lithuanian Association of Ultrasound Diagnostics.

Prof. Dr. A. Aidietis, Prof. Dr. V. Grabauskien臈, Prof. Dr. A. Kibarskis, Prof. Dr. G. Marinskis, Prof. Dr. G. Davidavi膷ius, Assoc. Prof. Dr. B. Petrauskien臈, Assoc. Prof. Dr. A. Rudys, Dr. J. Badarien臈, Assoc. Prof. Dr. J. Barysien臈, Dr. G. Burneikait臈, Dr. I. Butkuvien臈, Dr. A. 膶ypien臈, Dr. R. 膶ypien臈, Dr. R. K奴gien臈, Dr. D. Liekien臈, Dr. V. Maneikien臈, Dr. J. Misi奴ra, Dr. L. Ryli拧kyt臈, Dr. E. Rink奴nien臈, Dr. P. Sem臈nien臈, Dr. R. Stepon臈nien臈, Dr. R. Navickas, Dr. G. Ra膷kauskas 鈥�

members of European Society of Cardiology;
members of Lithuanian Heart Association;
members of Lithuanian Society of Cardiology.

Dr. R. 膶ypien臈, M. Budra, Dr. I. Butkuvien臈, E. Gai啪auskas, Dr. L. Gumbien臈, Dr. 沤. Katliorien臈, Dr. V. Lebetkevi膷ius, A. Lipnevi膷ius, Dr. D. Liekien臈, Dr. V. Maneikien臈, Dr. G. Nork奴nas, Dr. P. Sem臈nien臈, Dr. R. Sipavi膷ius, A. Zorinas 鈥�

members of Lithuanian Society of Thoracic and Cardiac Surgeons.

MOST IMPORTANT NATIONAL AND INTERNATIONAL AWARDS RECEIVED FOR R&D ACTIVITIES

Assoc. Prof. J. Barysien臈鈥� Order of the Lithuanian Grand Duke Gediminas;
Prof. J. 膶elutkien臈鈥� Winner Prize for HF Awreness Day (HFA).

MOST IMPORTANT PARTICIPATION CASES OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

Prof. J. 膶elutkien臈 鈥�

The Heart Failure Association of the ESC (HFA of the ESC)] Board member;
ESC Congress Program Committee member;
ESC Membership Committee member.

Prof. P. 艩erpytis 鈥�

Working groups of the Lithuanian Ministry of Health;
Lithuaniann Health Ministry working group of law number V-208 (dated April 8th, 2004) For ratification of the emergency medicine care and emergency medicinine service provision order and extent;
Working group of Emergency medicine service for traumas and other external conditioned injuries (Trauma cluster);
Working group of Formation health supervision administrative comity for integrated pathologies in health supervision control council for cardiology, oncology, stroke and perinathology (Cardiology cluster);
Working group for use of ECMO system in emergency medicine service.

Dr. J. Badarien臈 鈥�

Working group for Medicines Compensation of the Lithuanian Ministry of Health.

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

Heart Failure Awareness Days 鈥� May 2018.
The World Heart Day 鈥� September 29.
Familial hypercholesterolemia Awareness Days - September 24.

CLINIC OF CHILDREN鈥橲 DISEASES

4 Santari拧ki懦, LT- 08406 Vilnius
Tel. 249 2414
E-mail:

Head 鈥� Prof. Habil. Dr. Vytautas Usonis

STAFF

Professors: Dr. R. 膶erkauskien臈, Dr. N. Drazdien臈, Dr. R. 臇mu啪yt臈, Dr. A. Jankauskien臈, Dr. O. Rudzevi膷ien臈, habil. Dr. V. Usonis, Habil. Dr. A. Valiulis.
Associate professors: Dr. S. Dum膷ius, Dr. J. Grikinien臈, Dr. O. Kin膷inien臈, Dr. G. Kleinotien臈, Dr. V. Panavien臈, Dr. S. Petraitien臈, Dr. V. Urbonas, Dr. R. Vankevi膷ien臈, Dr. V. 沤ilinskait臈.
Assistants: Dr. S. Burokien臈, Dr. I. Iva拧kevi膷ien臈, Dr. A Liub拧ys, Dr. J. Rascon, Dr. I. Stacevi膷ien臈.
Dr. R. Samaitien臈, Dr. R. Praninskien臈, Dr. G. Vaitkevi膷ien臈, Dr. S. 艩aulyt臈 Trakymien臈, Dr. S. Rusonien臈, Dr. I. Pilypien臈.
Junior assistants and scientific workers: D. Kalibatien臈 S. Send啪ikait臈, D.Ruzgien臈.
Lecturers: Dr. R. Keme啪ys, V. Rad啪i奴nien臈, D.Vai膷i奴nien臈, L. Kilait臈.
Doctoral students: T. Alasevi膷ius, K. A啪ukaitis, J. Navikien臈, I. Paulavi膷ien臈, A. Pliauckien臈, I. Polianskyt臈, R. Selvestravi膷ius, S. Send啪ikait臈, N. Stirbien臈, D. Kalibatien臈, I. Ju拧kien臈.
Students鈥� scientific groups of: Pediatrics: scientific leader 鈥� Dr. S. Burokien臈, coordinator 鈥� student J. Karlonait臈, 50 members of the group.

RESEARCH AREAS

Health care of mother and child: physiological and social aspects and research of natural development of the child
Studies of functional development of organs and systems of newborns and children
Studies of neonatal pathology and perinatal mortality in Lithuania
Studies of chronic inflammation in paediatric pulmonology (asthma, cystic fibrosis, COPD) and elaboration of markers of early diagnostics of chronic diseases in children
Development of the methods of diagnostics, treatment and prophylaxis of acute and chronic infectious, immune, allergic, metabolic, haematologic and oncohaematologic diseases
Progression and outcomes of pediatric renal disorders
Studies of immunoprophylaxis and vaccination
Diagnostics and treatment of inherited metabolic diseases
Diagnostics, treatment and prophylaxis of children鈥檚 abuse and trauma

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Studies of Development of the Methods of Diagnostics, Treatment and Prophylaxis of Acute and Chronic Infectious Diseases. Project Leader 鈥� Prof. V. Usonis.

A standardized antimicrobial point prevalence surveys (PPS) method was employed to determine the feasibility of developing similar quality indicators of improved antimicrobial prescribing focusing specifically on hospitalized neonates and children. The use of antibiotics among hospitalised children at two tertiary paediatric centres (Riga and Vilnius) was compared; further investigations are needed because sharing audit data and antimicrobial stewardship initiatives may encourage further changes in practice at both institutions. Sepsis epidemiology and outcome in the paediatric ICU of 91桃色 Children鈥檚 Hospital was investigated; it was shown that the majority of lethal cases of sepsis occur in patients suffering from chronic co-morbidities, such as oncologic, hematologic, neurologic, and others.

Main publications:

Falup-Pecurariu, O. G., Diez-Domingo, J., Esposito, S., Finn, A., Rodrigues, F., Spoulou, V., Syrogiannopoulos, G.A., Usonis, V., Greenberg, D. 2018. Clinical and laboratory features of children with community-acquired pneumonia are associated with distinct radiographic presentations. European Journal of Pediatrics, vol. 177, iss. 7, p. 1111鈥�1120, doi: 10.1007/s00431-018-3165-3.

Versporten, A., Zarb, P., Caniaux, I., Gros, M.-F., Drapier, N., Miller, M., Jarlier, V., Nathwani, D., Goossens, H., Usonis V., Burokiene S., Ivaskeviciene I. 2018. Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey. The Lancet Global Health, vol. 6, Iss. 6, E619鈥揺629, doi: 10.1016/S2214-109X(18)30186-4.

Sviestina, I., Usonis, V., Gurksniene, V., Burokiene, S., Ivaskeviciene, I., Mozgis, D. 2018. Prescription of antibiotics in Riga and Vilnius tertiary children鈥檚 hospitals. European Journal of Hospital Pharmacy, vol. 25, p. 189鈥�194.

Studies of Chronic Inflammation in Paediatric Pulmonology (Asthma, Cystic Fibrosis, COPD) and Elaboration of Markers of Early Diagnostics of Chronic Diseases in Children. Project leader 鈥� Prof. A. Valiulis.

Studies showed the importance of further research for better translation of wheezing phenotypes into clinical practice. The study which was aimed to evaluate the quality of lie (QoL) of Lithuanian children aged 5鈥�11 years with asthma concluded that the overall level and major determinants of QoL in them are comparable with Western populations; the pilot study on alpha-1 antitrypsin (AAT) and wheezing in early childhood showed no association between AAT concentration and respiratory distress severity nor with the time of the first wheezing episode and concluded that further research is needed to better understand the effects of AAT genotype not related to its concentration; participation in the development of a targeted update of the ARIA guidelines was taken.

Main publications:

Courbis, A.-L., Murray, R. B., Arnavielhe, S., Caimmi, D., Bedbrook, A., Van Eerd, M., De Vries, G., Dray, G., Agache, I., Morais-Almeida, M., Bachert, C., Bergmann, K.Ch., Bosnic-Anticevich, S., Brozek, J., Bucca, C., Camargos, P., Canonica, G., Walter; C., Warner; C., T., Fonseca, J. A., Haahtela, T., Kalayci, O., Klimek, L., Kuna, P., Kvedarien臈, V., Larenas Linnemann, D., Lieberman, P., Mullol, J., Ohehir, R., Papadopoulos, N., Price, D., Ryan, D., Samolinski, B.,Simons, F. E., Tomazic, P., Triggiani, M., Valiulis, A., Valovirta, E., Wagenmann, M., Wickman, M., Yorgancioglu, A., Bousquet, J. 2018. Electronic Clinical Decision Support System for allergic rhinitis management: MASK e-CDSS. Clinical and Experimental Allergy, vol. 48, iss. 12, p. 1640鈥�1653, doi: 10.1111/cea.13230.

Bousquet, J., Agache, I., Aliberti, M.R., Angles, R., Annesi-Maesano, I., et al. [From 91桃色 Faculty of Medicine Dubakien臈, R., 臇mu啪yt臈, R., Kvedarien臈, V., Stukas, R., Valiulis, A.] 2018. Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - EIP on AHA Twinning Reference Site (GARD research demonstration project). Allergy, vol. 73, iss. 1, p. 77鈥�92, doi: 10.1111/all.13218.

Studies on Diagnostics, Treatment and Prophylaxis of Immune, Inflammatory, Metabolic, and Oncohaematologic Diseases in Children. Project leader 鈥� Prof. A. Jankauskiene.

Studies showed experience in the better outcome of childhood acute and chronic diseases such as nephrological, rheumatologic, gastroenterologic and, oncohematologic. Recent interest is being developed in rare diseases. Wide collaboration was established and continues. Multidisciplinary team allows wider research possibilities stressing on primary immunodeficiency, inborn metabolic defects, and renal diseases.

Main publications:

Burgmaier, K., Kunzmann, K., Ariceta, G., Bergmann, C., Buescher, A. K., Burgmaier, M., Dursun, I., Duzova, A., Eid, L., Erger, F., Feldkoetter, M., Galiano, M., Ge脽ner, M., Goebel, H., Gokce, I., Haffner, D., Hooman, N., Hoppe, B., Jankauskiene, A., Klaus, G., K枚nig, J., Litwin, M., Massella, L., Mekahli, D., Melek, E., Mir, S., Pape, L., Prikhodina, L., Ranchin, B., Schild, R., Seeman, T., Sever, L., Shroff, R., Soliman, N. A., Stabouli, S., Stanczyk, M., Tabel, Y., Taranta-Janusz, K., Testa, S., Thumfart, J., Topaloglu, R., Weber, L.Th., Wicher, D., W眉hl, E., Wygoda, S., Yilmaz, A., Zachwieja, K., Zagozdzon, I., Zerres, K., D枚tsch, J., Schaefer, F., Liebau, M.C. 2018. Risk factors for early dialysis dependency in autosomal recessive polycystic kidney disease. The Journal of Pediatrics, vol. 199, p. 22鈥�28.e6, doi: 10.1016/j.jpeds.2018.03.052.

Brunner, H.I., Ruperto, N., Tzaribachev, N., Horneff, G., Chasnyk, V.G., Panaviene, V. et al. 2018. Subcutaneous golimumab for children with active polyarticular-course juvenile idiopathic arthritis: results of a multicentre, double-blind, randomised-withdrawal trial. Annals of the Rheumatic Diseases, vol. 77, iss. 1, p. 21鈥�29, doi: 10.1136/annrheumdis-2016-210456.

Tesi, B., Rascon, J., Chiang, S.C.C., Burnyte, B., Lofstedt, A. et al. 2018. A RAB27A 5 ' untranslated region structural variant associated with late-onset hemophagocytic lympho-histiocytosis and normal pigmentation. Journal of Allergy and Clinical Immunology, vol. 142, iss. 1, p. 317鈥�321 Q1, if 13,528

INTERNATIONAL RESEARCH PROJECTS

PED-MERMAIDS (Multi-centre EuRopean study of MAjor Infectious Disease Syndromes)- part of the EU project PREPARE (Platform for European Preparedness Against (Re-) emerging Epidemics), funded by the European Commission鈥檚 FP7 Programme under grant number 602525.
Leader for Lithuania 鈥揚rof. Habil. Dr. V. Usonis.
International study conducted since 2016.

Multi-centre EuRopean study of Major Infectious Disease Syndromes鈥� Community acquired Sepsis-like syndrome and acute respiratory tract infection in childhood (PED-MERMAIDS)
Children can get really poorly from nasty bugs, which cause blood infections (known to doctors as sepsis) and chest infections. Often these children are so unwell they have to go to hospital. Rarely, long-term problems and even death can result from the infection.
In the past bacteria were the main causes for many severe infections; however, due to successful vaccine programmes, viruses are now mostly to blame. These bugs are worrying as they have the potential to cause a large-scale outbreak affecting the health of many people, as was the case in the recent world-wide Swine 鈥榝lu outbreak.
A better understanding of the role of viruses will help us to diagnose and manage affected children and work out how to better respond to outbreaks.
The European Commission is concerned about these infections and is funding a number of studies. Through this study we will look at the causes, symptoms, clinical management, impact and outcomes at lots of different sites across Europe.
The study will recruit:
1) Hospitalised infants (<6 months old) with signs of blood infections
2) Hospitalised children (<6 years old) with signs of chest infections
3) 鈥楬ealthy鈥� children without disease as a control group
We will collect one-off samples on the day of admission, including nose swabs, urine, blood and stool samples, as well as any left-over cerebrospinal fluid (CSF), if taken as part of routine treatment, along with other information from the child鈥檚 medical notes. Only very few children with blood infections will have follow-up in one year. Excluding these children, the maximum duration children will be involved in the study will be 30 days, with the overall study running for up to 3 years.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

University of Heidelberg (Germany)
University of Cologne (Germany)
University of Bologna (Italy)
Bambino Gesu Hospital, Rome (Italy)
Karolinska Institutet and Karolinska University Hospital (Swedish)

OTHER SCIENTIFIC ACTIVITIES

Prof. Habil. Dr. V. Usonis 鈥�

member of Central European Vaccination Advisory Group (CEVAG);
expert on vaccine-related issues at the European Disease Control Centre (ECDC);
board member of the Lithuanian Paediatric Society;
chairman of the Baltic Immunoprophylaxis Association (BALTIPA);
chairman of Lithuanian Committee for Poliomyelitis Eradication Certification;
editorial board member of the Paediatric Infectious Disease Journal;
editorial board member of the journal Medicinos teorija ir praktika (Theory and Practice in Medicine);
editorial board member of the journal Vaik懦 pulmonologija ir alergologija (Paediatric Pulmonology and Allergology);
editorial board member of the journal Pediatrija (Paediatrics);
chairman of the international conference Vilnius Course 2017.

Prof. R. 膶erkauskien臈 鈥�

vice-president of Lithuanian Society for Paediatric Nephrology;
member of Lithuanian Nephrology, Dialysis and Transplantation Association;
member of International Paediatric Nephrology Association;
member of Vilnius Paediatric Society;
editorial board member of the journal Medicinos teorija ir praktika (Theory and Practice in Medicine).

Prof. N. Drazdien臈 鈥�

editor-in-chief of the journal Lietuvos aku拧erija ir ginekologija (Lithuanian Obstetrics and Gynaecology);
editorial board member of the journal Pediatrija (Paediatrics);
board member of Lithuanian Paediatric Society and Vilnius Pediatric Society;
member of the European Association on Perinatal Medicine;
vicepresident of Lithuanian section of German-Baltic Physicians Society (Deutsch-Baltische Arztegesellschaft).

Prof. R. 臇mu啪yt臈 鈥�

editorial board member of the journals: Vaik懦 pulmonologija ir alergologija (Paediatric Pulmonology and Allergology); Alergologija ir klinikin臈 imunologija (Allergology and Clinical Immunology); Medinfo; Pediatrija (Paediatrics);
international editorial board member of the journal Alergia astma immunologia (Allergy Asthma Immunology) (Poland);
Lithuanian representative in European Training Committee of Paediatric Allergology;
national representative of European ARIA (Allergic Rhinitis and its Impact on Asthma) Committee;
member of the Lithuanian Society of Allergology and Clinical Immunology.

Prof. A. Jankauskien臈 鈥�

member of European Pediatric Nephrology society council;
leader of Vilnius reference center for European rare kidney disease;
president of Lithuanian Society for Paediatric Nephrology;
member of Lithuanian Nephrology, Dialysis and Transplantation Association;
member of International Paediatric Nephrology Association;
member of Dialysis working group of the European Society for Paediatric Nephrology;
member of International Paediatric Hypertension Association;
member of Lithuanian Paediatric Society;
member of regional bioethical committee.

Prof. Habil. A. Valiulis 鈥�

executive Committee member and Treasurer of European Academy of Paediatrics (EAP/UEMS-SP);
chairman of the Commission of Mother and Child of the Lithuanian Academy of Sciences;
chairman of Commission of Experts of National Programme of Immunoprophylaxis of Lithuanian Ministry of Health;
president of the Lithuanian Paediatric Respiratory Society;
vicepresident of the Lithuanian Paediatric Society;
chairman of Vilnius International Paediatric Pulmonology and Allergology; Conference-School (21 annual postgraduate courses since 1996);
editor-in-chief of the journal Vaik懦 pulmonologija ir alergologija (Paediatric Pulmonology and Allergology);
national Coordinator and Planning Committee member of WHO project Global Alliance Against Chronic Respiratory Diseases (WHO-GARD Lithuania);
national Coordinator and Representative of Lithuania in International Guidelines of Allergic Rhinitis and its Impact on Asthma (ARIA Lithuania);
site Coordinator in international research projects MACVIA MASK, AIRWAYS ICP, RareBestPractice;
member of Strategic Paediatric Alliance for the Future Health of Children in Europe (EAP-EPA-ECPCP).

Assoc. Prof. S. Dum膷ius 鈥�

member of the European Respiratory Society;
member of the European Cystic Fibrosis Association;
editorial board member of the journal Pediatrija (Paediatrics).

Assoc. Prof. J. Grikinien臈 鈥�

member of Lithuanian Association of Neurology;
member of Lithuanian Paediatric Neurology Society;
member of Lithuanian Society of Epileptology;
member of Lithuanian Paediatric Society.

Assoc. Prof. O. Kin膷inien臈 鈥�

president of the Lithuanian Paediatric Cardiology Society;
deputy editor of the journal Pediatrija (Paediatrics).

Assoc. Prof. V. Panavien臈 鈥�

member of Paediatric Rheumatology European Society (PRES);
national representative in the PRES Training and Education Committee;
member of Paediatric Rheumatology International Trial Organisation (PRINTO);
member of the Council of Lithuanian Rheumatology Association;
editorial board member of the journal Pediatrija (Paediatrics);
editorial board member of the journal Reumatologija (Rheumatology).

Assoc. Prof. S. Petraitien臈 鈥�

member of Scientific Committee of Vilnius International Course 2017 (VICO-2017) Update on Paediatric Infectious Diseases,
editorial board member of the journal Paediatric Pulmonology and Allergology,

Assoc. Prof. V. Urbonas 鈥�

president of the Lithuanian Paediatric Society;
president of the Lithuanian Society for Paediatric Gastroenterology and Nutrition;
consultant as paediatric gastroenterologist at the Ministry of Health of the Republic of Lithuania;
board member of Lithuanian Society for Parenteral and Enteral Nutrition;
member of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN);
member of the European Society for Parenteral and Enteral Nutrition (ESPEN);
editorial board member of the journal Gastroenterologija ir hepatologija;
editorial board member of the journal Pediatrija

Assoc. Prof. R. Vankevi膷ien臈 鈥�

president of Vilnius Paediatric Society;
member of the Council of Lithuanian Paediatric Society;
member of Lithuanian Paediatric Cardiology Society;
editorial board member of the journal Pediatrija (Paediatrics).

Assoc. Prof. V. 沤ilinskait臈 鈥�

board member of the Lithuanian Paediatric Intensive Care Society;
member of the European Society of Intensive Care Medicine;
editorial board member of the journal Pediatrija (Paediatrics).

Senior reseach fellow R. Firantien臈鈥�

member of the Lithuanian Society of Allergology and Clinical Immunology.

Assioc. Prof. J. Rascon 鈥�

board member of Nordic Society of Pediatric Oncology and Hematology;
member of European Society for Blood and Marrow Transplantation;
member of European Society of Pediatric Oncology.

Assist. S. Burokien臈 鈥�

member of Scientific Paediatric Committee (PDCO) at European Medicines Agency.

Lect. R. Keme啪ys 鈥�

editorial board member of the journal Baltic Endocrinology;
member of Lithuanian Paediatric Endocrinology Association;
member of the International Growth Hormone Research Society (GRS);
member of the European Society of Endocrinology (ESE);
member of International Society for Paediatric and Adolescent Diabetes (ISPAD).

Assist. I. Iva拧kevi膷ien臈 鈥�

member of the Lithuanian Paediatric Society;
executive secretary of Baltic Immunoprophylaxis Association;
member of the European Society of Paediatric Infectious Diseases (ESPID);
member of the Young ESPID (European Society of Paediatric Infectious Diseases) Society;
member of Central European Vaccination Advisory Group (CEVAG).

MOST IMPORTANT NATIONAL AND INTERNATIONAL AWARDS RECEIVED FOR R&D ACTIVITIES

Vaidotas Urbonas. Gedimino ordino Riterio kry啪ius
Karolis A啪ukaitis. 91桃色 Faculty of Medicine 鈥淪ophie Valentina Ambroza Research Award鈥�

MOST IMPORTANT PARTICIPATION CASES OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

S. Burokiene:

Lithuanian Health Ministry. The member of the working group: 鈥淧aediatric work standart鈥� (requirements and competence for pediatrician鈥檚 specialty).
Lithuanian Health Ministry. The member of the working group: 鈥淥ptimisation of children鈥檚 health in Lithuania鈥�.
Lithuanian Health Ministry. The member of the working group: 鈥淚mprovement of emergency

V. Urbonas:

Lithuanian Health Ministry. The member of the working group: 鈥淧aediatric work standart鈥�.
Lithuanian Health Ministry. The member of the working group: 鈥淥ptimisation of children鈥檚 health in Lithuania鈥�.

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

V. Usonis. Participation at television broadcasts (topics: children diseases, children infectins, vaccination) on national (LTV) and private televisions (LNK, TV3, Lietuvos ryto, TV8).

S. Burokiene. Interview in media - Delfi, 15 min, TV3, LTV (topics: How to prepare child for the hospital; Emergency assistance to child in case of acute illness)

V. Urbonas. Participation at television broadcasts (topics: children diseases, children diet, vegetarian diet) on national (LTV) and private televisions (LNK, TV3, Lietuvos ryto, TV8).Participation at the national radio broadcasts (Topics: children diseases, children diet, vegetarian diet, health care organization. LRT, 沤ini懦 radijas).

CLINIC OF INTERNAL MEDICINE, FAMILY PRACTICE AND ONCOLOGY

2 Santari拧ki懦, LT-08661 Vilnius
Tel. 236 5075
E-mail:

Head 鈥� Prof. Dr. Virginijus 艩apoka

STAFF

Professors: Dr. V. 艩apoka, Dr. V. Kasiulevi膷ius, Dr. V. Alekna, Dr. L. Gri拧kevi膷ius, Dr. N. Samalavi膷ius, Habil. Dr. D. Kalibatien臈, Habil. Dr. V. Gaigalait臈, Dr. V. Ostapenko (part-time).
Associate professors: Dr. V. Urbanavi膷ius, Dr. E. Mi拧eikyt臈 Kaubrien臈, Dr. V. D啪enkevi膷i奴t臈, Dr. 沤. Visockien臈, Dr. V. O啪eraitien臈, Dr. L. Vencevi膷ien臈 (part-time).
Chief researcher: Dr. S. Cic臈nas.
Assistants professors: Dr. A. Abraitien臈, Dr. V. Pe膷eli奴nas, Dr. A. Marcijonien臈 (part-time), Dr. K. Simanauskas (part-time), N. Burokien臈 (part-time), V. Andrejevait臈 (part-time), Dr. S. Varvuolyt臈, Dr. R. Staigis (part-time), Dr. V. Karpavi膷ien臈 (part-time), Dr. O. Ne膷ajauskait臈 (part-time).
Teaching assistant: R. Laukien臈 (part-time), K. 艩vaikevi膷ien臈 (part-time).
Lecturers: A. Slobinas (part-time), S. Tulyt臈 (part-time), L. Vaitkevi膷i奴t臈 (part-time), D. Diglys (part-time), A. Galkin臈 (part-time), E. Vitkauskait臈 (part-time), G. Jonu拧kien臈 (part-time), A. Degulys (part-time), I. Fom膷enko (part-time), D. Jaku膷ionis (part-time), M. Buitkus (part-time), E. Gruodyt臈 (part-time), E. Bagurskien臈 (part-time), dr. A. Mastavi膷i奴t臈 (part-time), T. Maselien臈 (part-time).
Doctoral students: R. A拧kinis, A. Krasauskas, A. Galkin臈, R. Kavalnien臈, N. Lachej, R. Pileckyt臈, V. Dirs臈, J. Moz奴raitien臈, I. Aleknait臈, J. Bublevi膷, A. Bli奴d啪ius, A. 膶ernovas..
Scientific groups of students:
Internal medicine: scientific leader 鈥� Assoc. Prof. V. D啪enkevi膷i奴t臈, coordinator 鈥� student J. 艩imk奴nien臈; 19 members of students.
Gerontology: scientific leader 鈥� Prof. V. Alekna, coordinator 鈥� student G. Sadauskait臈; 23 members of students.
Oncohematology: scientific leader 鈥� Dr. 沤. Gudlevi膷ien臈, coordinator 鈥� student I. Ali拧auskait臈; 59 members of students.
Endocrinology: scientific leader 鈥� Dr. A. Abraitien臈, coordinator 鈥� student G. Kazakevi膷i奴t臈; 46 members of students.
Family medicine: scientific leader 鈥� Dr. V. Andrejevait臈, coordinator 鈥� student A. Vy拧niauskait臈; 84 members of students.

RESEARCH INTERESTS

Etiopathogenesis, Diagnostics, Treatment of Diseases: Fundamental and Clinical Research, Innovative Technologies
Early Diagnostics and Prevention of Non-infection Diseases in Family Practice and in Gerontology
Biomarker Research in Hematology and Oncology
Investigation of Etiopathogenetic Risk Factors and Quality Of Patients鈥� Life With Internal Diseases

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Early Diagnostics and Prevention of Non-Infectious Diseases in Family Practice. Prof. V. 艩apoka, Prof. V. Kasiulevi膷ius. 2013鈥�2018.

The aim was to assess leptin, adiponectin and insulin resistance changes after laparoscopic adjustable gastric banding (LAGB) in diabetic and non-diabetic morbidly obese patients. 103 patients (37 with and 66 without type 2 diabetes) underwent LAGB from January 2009 to January 2010. Glycated hemoglobin, insulin, adipokine levels and insulin resistance were evaluated preoperatively, 1 and 4-years after LAGB. The most significant metabolic changes occurred within 1 year after LAGB. Subsequent 4 years of follow-up revealed stabilization in metabolic indices rather than significant improvement.

Main publication:

Holman, R.R., Bethel, M. A., Mentz, R.J., et al. Group Author(s): EXSCEL Study Grp. 2018. Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes. New England Journal of Medicine, vol. 377, iss. 13, p. 1228鈥�1239, doi: 10.1056/NEJMoa1612917.

The influence of social and demographic factors, depression and anxiety on patient satisfaction with primary care.

The review of scientific literature about patients satisfaction with primary health care in Lithuania and other countries, also about the impact of biosocial factors and patients鈥� mental health on satisfaction with primary health care was continued. The study has already surveyed 889 patients, who visited their primary health care institutions in Vilnius. Data are prepared for statistical analysis.

Values of Oncological Diseases and Blood Biological Markers. Prof. L. Gri拧kevi膷ius, Prof. J. Did啪iapetrien臈. 2013鈥�2018.

Analyzing the clinical trials already performed, when the ERCC1 and RRM1 genes were included and the treatment chosen for their expression and obtaining favorable results, and also in light of controversial authors鈥� data, it is expedient to carry out additional molecular studies to determine the gene expression of the DNA repair system. Thus, a molecular diagnosis of a tumor is planned, an individual postoperative treatment of patients by choosing the optimal treatment regimen after progression of the disease through chemotherapy in order to obtain the best treatment results and predicting the possible further course of the disease. Conclusions: low levels of ERCC1 and RRM1 gene expression in the bloodstream are directly related to better disease prediction and better response to postoperative treatment. Only the RRM1 (-524C 鈫� T) gene polymorphism in the blood is associated with the progression of the disease after treatment.

A Population-Based Single Nucleotide Polymorphism Array Analysis of Genomic Aberrations in Younger Adult Acute Lymphoblastic Leukemia Patients.

Single nucleotide polymorphism (SNP) array analysis was performed for Lithuanian adult ALL patients diagnosed between 2013 and 2018. Recurrent chromosomal aberrations were detected in double expressor and non-double expressor immunohistochemical subtypes of DLBCL.Combined FISH and SNP array analysis indicated MYC aberrations to be initiating events and possibly responsible for generating secondary genomic abnormalities. The extended analysis for the detection of recurrent genomic aberrations and clonal evolution (in relapsed cases) in adult ALL was performed in year 2018.Using SNP array a rare microduplication 22q11.2 was detected in patient with acute B lymphoblastic leukemia and severe intellectual disability, facial dysmorphism, heart defects.

Main publication:

Vaisvilas, M., Dirse, V., Aleksiuniene, B., Tamuliene, I., Cimbalistiene, L., Utkus, A., Rascon, J. 2018. Acute pre-B lymphoblastic leukemia and congenital anomalies in a child with a de Novo 22q11.1q11.22 duplication. Balkan J Med Genet, vol. 21(1), p. 87鈥�91, doi: 10.2478/bjmg-2018-0002.

Chronic B lymphocytic leukemia (CLL): report of the results for 2018 year

Progression free survival (PFS), overall survival (OS) evaluated for relapsed high risk and elderly patients with comorbidities, treated with high dose methylprednisolone (HDMP) and rituximab (R).Time to next treatment calculated for both patients groups. Given salvage treatment were described and OS difference between two patients groups were evaluated. Results between two cohorts of the patients were compared and treatment recommendations for high risk patients and elderly patients with comorbdities was described. HDMP and Rtx combination may be applied in some relapsed high risk patients, using 5-day HDMP regimen and 3-day in elderly or unfit CLL patients with shorter HDMP duration for 4 treatment courses in combination with Rtx of total 3375 mg/m2 dose without the significant risk of concomitant diseases exacerbation if new targeted therapies are contraindicated, have limited availability or taking into mind patients preference for short therapy duration.

E3 ubiquitin ligase inhibitors (RITA and Nutlin-3) in human metastatic melanoma cell lines.

The aim of study was to establish effect of FBW7 activator oridonin (new potential agent for melanoma cell killing) and MDM2 inhibitors nutlin-3/RITA and their combination to viability of melanoma cell lines FM-94 and FM-3 (cell lines was selected according to primary results of experiments). Conclusions: The most effective inhibitory effect was on 30 渭M oridonin concentrations for both FM-94 and FM-3 cell lines.

mRNA expression of FBW7, MDM2 and their substrates 鈥� NUMB, NOTCH, TP53, CCNE, BBC3, C-MYC after effect of metastatic melanoma cells with oridonin and nutlin-3/RITA.

To establish mRNA expression of FBW7, MDM2 and their substrates 鈥� NUMB, NOTCH, TP53, CCNE, BBC3, C-MYC after effect of metastatic melanoma cells with oridonin and nutlin-3/RITA.

After the effect of the FM-94 cell line with nutlin-3 it was showed that the MDM2 gene expression was the most pronounced: compared to HPRT1 (鈥瀐ousekeeping gene鈥�), it was almost 8 times, compared with the TBP (鈥瀐ousekeeping gene鈥�) 鈥� 6 times. Conclusions: After the effect of the FM-94 cell line with RITA and oridonin, there was activation of genes associated with apoptosis (BBC3) and cell cycle-inducing genes (c-MYC) were inhibited.

The expression of Hes1, Notch1, Notch4 proteins and 尾-catenin in endometrial cancer patients.

About 50 paired samples of endometrial cancer and adjacent nontumor endometrial tissue samples were analyzed by quantitative Western blot method. The analysis of the all data (N=100) from clinical point of view, analysis of progression free and overall survival period was started. The review of the literature was prepared.

Investigation of Quality of life of patients with diabetes aiming to validate disease specific questionnaire.

We aimed to develop a Lithuanian version of a widely-used individualised instrument - the Audit of Diabetes Dependent Quality of Life questionnaire (ADDQOL-19) and assess the validity and reliability in patients with type 1 and type 2 diabetes mellitus (DM). Conclusions: We developed the Lithuanian version of ADDQOL-19 which is a valid and reliable instrument to measure impact of diabetes on QOL. It could be further used by clinicians and researchers for comprehensive assessment of QOL in adults with diabetes.

Main publication:

Visockiene, Z., Narkauskaite-Nedzinskiene, L., Puronaite, R., Mikaliukstiene, A. 2018. Validation of the Lithuanian version of the 19-item audit of diabetes depended quality of life (ADDQoL) questionnaire in patients with diabetes. Health Qual Life Outcomes, vol. 16, no. 1, 206, doi: 10.1186/s12955-018-1033-5.

Project Joint Action on Chronic Diseases and Promoting Healthy Aging across the Life Cycle, (JA-CHRODIS)

Chronic diseases account for 85 per cent of the disease burden and pose a great challenge on health systems. Especially, among elderly the chronic diseases are responsible for a loss of quality of life, reduced independence, and decreased functionality. JA-CHRODIS has received funding from the European Union, in the framework of the Health Programme. We have analysed data of almost 500.000 patients with at least one chronic condition from Lithuanian National Health Insurance. Conclusions: The risk of acquiring an additional chronic condition rises exponentially from the age of 29 years and platos between the age of 51 and 57. Patients with multimorbidity require increasing amounts of primary healthcare resources, where patients with single chronic condition require decreasing primary care usage, possibly attributed to successful patient empowerment.

Main publication:

Jurevi膷ien臈, E., Onder, G., Visockien臈, 沤., Puronait臈, R., Petrikonyt臈, D., Gargalskait臈, U., Kasiulevi膷ius, V., Navickas, R. 2018. Does multimorbidity still remain a matter of the elderly: Lithuanian national data analysis. Health Policy, vol. 122, no 6, p. 681鈥�686, doi: 10.1016/j.healthpol.2018.03.003.

Early Diagnostics and Prevention of Non-infection Diseases in Gerontology. Prof. V. Alekna. 2013鈥�2018.

Vitamin D Level and Activities of Daily Living in Octogenarians: Cross-Sectional Study.

The study was performed on 153 octogenarians. Conclusions: Majority of investigated octogenarians had vitamin D deficiency. The level of vitamin D was associated with the ADL score. There was no association between the vitamin D level and the IADL score, although a weak correlation was found between vitamin D level and category of food preparation.

Main publication:

Alekna, V., Kilaite, J., Mastaviciute, A., Tamulaitiene, M. 2018. Vitamin D level and activities of daily living in octogenarians: cross-sectional study. Frontiers in Endocrinology, vol. 9, art. no 326, p. 1鈥�5, doi: 10.3389/fendo.2018.00326.

Association of Vitamin D Receptor Gene Variation with Osteoporosis Risk in Belarusian and Lithuanian Postmenopausal Women.

Vitamin D receptor (VDR) is one of the main mediators of vitamin D biological activity. VDR dysfunction might substantially contribute to development of postmenopausal osteoporosis (PMO). Numerous studies have revealed the effects of several VDR gene variants on osteoporosis risk, although significant variations in different ethnicities were suggested. The main purpose of this work was to assess the frequency of distribution of VDR genetic variants with established effect and evaluate their haplotype association with the risk of PMO in a cohort of Belarusian and Lithuanian women. Complex screening of these genetic markers can be used to implement personalized clinical approach for prevention, treatment, and rehabilitation programs.

Main publication:

Marozik, P.M., Tamulaitiene, M., Rudenka, E., Alekna, V., Mosse, I., Rudenka, A., et al. 2018. Association of vitamin D receptor gene variation with osteoporosis risk in Belarusian and Lithuanian postmenopausal women. Front Endocrinol, vol. 9, p. 305鈥�305, doi:10.3389/fendo.2018.00305

The relationships of vitamin D level and sarcopenia in elderly people.

The study was performed on 74 subjects. Mean vitamin D concentration in sarcopenic subjects was statistically significantly lower when compared to mean level of in non-sarcopenic subjects. After adjusting for confounders (age, gender, height, weight) the association between sarcopenia and low vitamin D concentration was still statistically significant. Conclusions: Low level of vitamin D is associated with sarcopenia in older adults.

Relations between Frailty, Multimorbidity and Disability in Specific Activities in Daily Living in Community-Dwelling Women: a Cross-Sectional Study.

The purpose of this sub-study was to investigate relations between frailty, multimorbidity and disability in elderly women. A cross-sectional study in community-dwelling women aged 60 years and more was conducted. Frailty was defined using the frailty phenotype according to Fried et al. criteria. Multimorbidity was defined as the presence of two or more self-reported chronic diseases. Disability in specific activities of daily living (ADL) was defined as needing help or being unable to perform one or more basic or instrumental ADL assessed using Katz and Lawton scales. Higher rates of multimorbidity and IADL disability were found in frail women compared to prefrail and robust women.

Relationship between falls, medication usage and chronic diseases in elderly women.

The purpose of this sub-study was to investigate the association between falls, usage of medication and presence of chronic diseases. Community-dwelling ambulatory women aged 65 years and older who had fallen in previous 12 months were included in this study. Data on fall history, medication and chronic diseases were collected. There was a very weak correlation between amount of medication used and number of falls.

Research of the Etiopathogenesis of Internal Diseases, Detection of Optimal Diagnostic and Treatment Methods. Prof. D. Kalibatien臈. 2014鈥�2018. Project Supported by University Budget.

Research interests were: investigation and scientific evaluation of etiopathogenesis of cardiovascular, digestive diseases, lung cancer and diabetes mellitus; development of optimal methods of diagnosis and treatment of internal diseases; investigation of quality of life of patients with internal diseases; survey of nursing care needs of patients with cardiovascular, respiratory and digestive diseases.

Chronic Heart Failure Patient鈥檚 Health-related Quality of Life and Self-care Level. Prof. D. Kalibatien臈. 2014鈥�2018.

209 respondents participated in the research. Minnesota Living with Heart Failure questionnaire (MLHFQ) was used for the evaluation of life quality relevant to health. Statistical data analysis was performed with statistical analysis 鈥淪PSS 15.0鈥�. Life quality of 29 percent of studied respondents was bad and very bad. Life quality was defined as significantly better in case of men in compare to women, also in case of younger respondents in compare to older, in case of married in compare to singles and widows/widowers, in case of respondents with job in compare to unemployed and retired, with higher education.

Health care quality assessment in cardiology center: viewpoint of patients. Prof. D. Kalibatien臈. 2014鈥�2018.

A total of 200 patients were interviewed at the Cardiology Center of Vilnius hospital. The patients鈥� expectations and impressions about the health care were evaluated. The patients assessed their expectations in relation with the hospital concerned in high scores. Higher education of the patients was associated with lower expectations towards the hospital tangible assets, its reliability and staff sensitivity. The patients interviewed had higher expectations than their final feedback. The significant correlation between the patients' expectations with regard to the hospital and their feedback was identified.

Main publications:

Kalibatien臈, D., Rusecka, B., Markevi膷ius, N. 2018. Chronic heart failure patient鈥檚 health-related quality of life and self-care level. Health Sciences, vol. 28, no. 5, p. 6鈥�12.

Mikali奴k拧tien臈, A., Baltokait臈, L., Kalibatien臈, D., Jerdiakova, N. 2018. Health care quality assessment in cardiology center: viewpoint of patients. Health Sciences, vol. 28, no 5, p. 32鈥�40.

The Evaluation of Nursing Needs, Quality of Life, and Perfection of Health Care and Education of Patients.

Nurses鈥� role in using non-pharmacological methods of postoperative pain management in children. Prof. D. Kalibatien臈. 2014鈥�2018.

The research involved 89 nurses. The questionnaire, created by Dr Tarja P枚lkki (Finland), was adjusted and translated from Finnish to Lithuanian. Conclusions: The most frequent non-pharmacological methods of postoperative pain relief used by nurses were the information giving, positioning patients in bed, helping them with daily needs and comforting worried children. The nurses aged from 45 to 59 years old, with a higher academic degree, having a longer work experience, more actively participated in the management of postoperative pain relief in children and in their parents鈥� teaching.

The Relationship between Stress Coping Strategies and Personality Traits of the Nurses. Assoc. Prof. V. O啪eraitien臈. 2014鈥�2018.

Almost of half of the nurses (43%) working in the therapy and surgery units鈥� deal with stress using solution-oriented, active coping strategies. A significant relationship between problem solving and social support strategies of the subjects working in surgery and intensive care departments indicated that mostly teamwork and assistance could help them to cope with stressful situations accordingly. Strong relationship between psychological avoidance and of emotional discharge the subjects working in surgery and intensive care departments showed that emotional discharge and distraction from a certain issue could naturally reduce negative emotions.

Main publications:

Stund啪ien臈, R., Turlinskien臈, G., Kalibatien臈, D., Gim啪auskien臈, J., Gim啪auskait臈, S. 2018. Nurses鈥� role in using non-pharmacological methods of postoperative pain management in children. Health Sciences, vol. 28, no. 5, p. 71鈥�81.

O啪eraitien臈, V., Kisli奴t臈, 沤., Gaigalait臈, V. 2018. The relationship between stress management strategies and aspects of the nurses鈥� personality traits. Health Sciences, vol. 28, no. 5, p. 82鈥�88.

A possible causal link between VA hypoplasia (VAH) and the incidence of posterior circulation stroke (PCS) or TIA depending on the degree of VAH, collateral circulation and vascular risk factors.

The impact of the vertebral artery hypoplasia on PCS/TIA and its pathogenic mechanism was significantly influenced by age. In our population VA diameter 2.5 mm was cutoff point for PCS/TIA and VA diameter 2.2 mm was cutoff point for VA distal occlusion/stenosis. The cut-off point of VA diameter, affecting the occurrence of PCS in different populations may vary because VA diameter depends on gender and anthropometric parameters (especially height). Arterial hypertension, contralateral VA variation or lesions and male sex increase the PCS/TIA risk in patients with VAH.

The evaluation of non-pulmonary cancer risk following tuberculosis.

Lithuania remains one of the highest tuberculosis burden countries in Europe. Epidemiological studies have long pointed to infections as important factors of cancer aetiology, but the association between tuberculosis and the risk of non-pulmonary cancers has rarely been tested and results have been inconsistent. The aim of this population-based cohort study was to examine the risk of cancer among patients diagnosed with tuberculosis using data from Lithuanian Tuberculosis, Cancer and Resident's Registries. According to this cohort study, the recommendation for the awareness of this association among physicians is warranted. Analysis suggests a reduction in risk of hormone-related cancers and melanoma.

Health-related quality of life in patients with atrial fibrillation.

229 in-hospital patients with atrial fibrillation (AF) of 50鈥�70 age participated, quality of life (QoL) in relation to sociodemographic, clinical and individual indicators was evaluated. QoL was evaluated according to generic questionnaire SF-36 and disease specific questionnaire AF-QoL. The main statistically significant sociodemographic indicators that worsen QoL were defined as female gender, lower education, low income, unemployement. The following clinical factors influencing on quality of life were defined: as longer AF duration, more severe heart failure functional class, concomitant diseases.

The Evaluation of Nursing Needs and Quality of Life and Perfection of Health Care and Education of Patients.

The aim of the first research was to analyze and assess links between psychosocial risk factors and social reflection of nurses and nursing assistants. The European Union prevention and good practice guide questionnaire (2013) was used for this survey. Psychosocial risk factor indicators (stress, burnout, violence, mobbing, inappropriate work time organization) and indicators of social reflection were explored. Conclusions: Who worked in the internal medicine and surgery departments had a risk of stress, burnout, violence and inappropriate working time arrangements. Stress risk was significantly associated with lower education, shorter duration of service and respondents鈥� sickness rate. Burnout risk was significantly associated with work in surgery/intensive care team, marital status and shift/night work. Risk of mobbing was associated with shorter (up to 5 years) and longer (26 years and more) duration of service. Comparing the surgery and internal medicine nursing care team links between social reflection and psychosocial risk factors, stress risk was found to be significantly higher in the surgery team; however, burnout and inappropriate working time arrangement risks were significantly higher in the internal medicine departments.

Main publications:

Poskus, E., Kryzauskas, M., Poskus, T., Mikalauskas, S., Samalavicius, N.E., Aliosin, O., Dailidenas, S., Tamelis, A., Saladzinskas Z., Lizdenis P., Jakaitiene, A., Smailyte, G., Strupas, K. 2018. Improved perioperative care is associated with improved long-term survival in colorectal cancer. Int J Colorectal Dis., vol. 33(6), p. 779鈥�785, doi: 10.1007/s00384-018-3021-y. Epub 2018 Mar 12.

GlobalSurg Collaborative. 2018. Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study. Lancet Infect Dis, vol. 18, no 5, p. 516鈥�525, doi: 10.1016/S1473-3099(18)30101-4.

Dulskas, A., Smolskas, E., Kildusiene, I., Samalavicius, N.E. 2018. Treatment possibilities for low anterior resection syndrome: a review of the literature. Int J Colorectal Dis, vol 33, no 3, p. 251鈥�260, doi: 10.1007/s00384-017-2954-x.

The relationship between stress coping strategies and personality traits of the nurses.

Almost of half of the nurses (43%) working in the therapy and surgery units鈥� deal with stress using solution-oriented, active coping strategies. A significant relationship between problem solving and social support strategies of the subjects working in surgery and intensive care departments indicated that mostly team work and assistance could help them to cope with stressful situations accordingly. Strong relationship between psychological avoidance and of emotional discharge the subjects working in surgery and intensive care departments showed that emotional discharge and distraction from a certain issue could naturally reduce negative emotions.

National Research Projects

COST BM1201 Developmental Origins of Chronic Lung Disease. Prof. S. Cic臈nas 鈥� project manager.

Chronic Lung Diseases (CLD) are a major cause of death in the Western world according to the World Health Organization (WHO), but curative therapies do not exist and a highly cross-disciplinary approach involving scientists from basic and clinical research was required. COST Action allowed the creation of a coordinated and highly translational research program. This brought forward a novel understanding of CLD pathogenesis and built the prerequisites for the successful development of early interventions and/or innovative therapies. COST Action identifies potential causes of disease, using human clinical, genetic and environmental epidemiological cohort studies. This allows identifying and characterizing vulnerable populations, and clarifies how specific exposures impinge on genetic predisposition.

Main publication:

Stumbryt臈, A., Gudlevi膷ien臈, 沤., Kundrotas, G., Dabkevi膷ien臈, D. Kunickait臈, A. Cic臈nas, S. 2018. Individual and combined effect of TP53, MDM2, MDM4, MTHFR, CCR5, and CASP8 gene polymorphisms in lung cancer. Oncotarget, vol. 9, no. 3, p. 3214鈥�3229, doi: 10.18632/oncotarget.22756.

Predictive Values of ERCC1 and RRM1 for Clinical Outcome in Non-small Cell Lung Cancer. S. Cic臈nas 鈥� project principal.

A study was conducted to understand the genetic effect of ERCC1 and RRM1 on the chemotherapy response and clinical outcome of Non-Small Cell Lung Cancer (NSCLC). The relative cDNA quantification for ERCC1 and RRM1 was conducted using a fluorescence-based real-time detection method among 294 NSCLC patients.

First results can be found at This observation could be used in personalized chemotherapy, increase the response rate and prolonged survival time, and could encourage exploring the predictive value of other genes.

Main publications:

Socinski, M.A., Jotte, R.M., Cappuzzo, F., Orlandi, F., Stroyakovskiy, D. at al., Collaborator S. Cic臈nas. 2018. Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC. N Engl J Med, vol. 378, iss. 24, p.2288鈥�2301, doi: 10.1056/NEJMoa1716948.

Eide, I.J.Z., Helland, A., Ekman, S., Cicenas, S., Koivunen, J., et al. 2018. Rapid drop in blood platelet count and increase in creatinine in non-small cell lung cancer (NSCLC) patients treated with osimertinib. Journal of Clinical Oncology, vol. 36, iss.15, e21026, doi: 10.1200/JCO.2018.36.15_suppl.e21026.

Quality Improvement Using IT Technologies in Lung and Skin Diseases Diagnostic Services. Prof. S. Cic臈nas 鈥� project manager..

Collaboration among primary care practices, practice facilitators, IT developers, and decisionmakers to increase the use of health IT for QI in primary care. Main objectives were to share examples of exemplary uses and best practices to inspire and guide primary care practices seeking to create a culture that embraces using health IT for QI; continue to develop and refine technology to produce high-functioning, interoperable health IT tools; to empower primary care providers and staff with the necessary knowledge and skills to maximize the use of health IT for QI; to provide guidance and tools to help primary care practicesredesign processes and workflows to accommodate the effective use of health IT for QI; to expand the availability of financial and other transformation incentives and supports.

EuLuCA: European Initiative for Quality Management in Lung Cancer Care EIQMLCC. Prof. S. Cic臈nas 鈥� project principal.

The main objective was to assess whether prospective collection of demographic and clinical data of patients with lung cancer is feasible in a Pan-European context; to identify problems with this process: linguistic, related to information technology, related to data security, clinical management, or cost.

Main publication:

Chaudhri, S., Group Author(s). 2015 European Society of Coloproctology. 2018. The impact of stapling technique and surgeon specialism on anastomotic failure after right-sided colorectal resection: An international multi-centre, prospective audit. Colorectal Disease, vol. 20, iss. 11, p. 1028鈥�1040, doi: 10.1111/codi.14308.

The Lithuanian-French cooperation Program in the field of research and experimental development 沤iliberas: Developing BioBank Infrastructure for Oncological Patients for Future Research. Prof. S. Cic臈nas 鈥� project manager.

Objectives of the study were to develop and promote mutual cooperation in the field in scientific research and experimental expansion. Active participation in creating common space of European Scientific Research and Scientific Exchange.

Main publications:

Ka膷臈nien臈, A., Danila, E., Cic臈nas, S., Smailyt臈, G. 2018. Suicide risk among lung cancer patients in Lithuania. Clinical Respiratory Journal, vol. 12, iss. 9, p. 2455鈥�2456, doi: 10.1111/crj.12916.

Gedvilaite, V., Danila, E., Cicenas, S., Smailyte, G. 2018. P1.15鈥�09 Trends in lung cancer survival in Lithuania. Journal of Thoracic Oncology, vol. 13, iss. 10, S614, doi:

OTHER SCIENTIFIC ACTIVITIES

Prof. V. 艩apoka 鈥�

board member of International and European Society of Internal Medicine and prezident of Lithuanian Society of Internal Medicine;
editor-in-chief of journal Internistas (Internist);
president of Lithuanian Evidence-Based Medicine Society;
board member of journals Medicinos teorija ir praktika (Theory and Practice in Medicine), Geriatrija (Geriatrics) and Lietuvos bendrosios praktikos gydytojas (General Practitioner of Lithuania);
member of 91桃色 Senate.

Assoc. Prof. V. Urbanavi膷ius 鈥�

member of Eurodiabetes index 2015 committee;
editorial board member of journals Lietuvos endokrinologija (Endocrinology of Lithuania), Medicinos teorija ir praktika (Theory and Practice in Medicine), Diabetes Review and Internistas (Internist);
member of the organizing commitees of endocrinological conferences;
member of European Association of the Study of Diabete.

Prof. V. Alekna 鈥�

president of Lithuanian Osteoporosis Foundation;
editor-in-Chief of journal Gerontologija (Lithuania);
president Lithuanian Association of Gerontology and Geriatrics;
board member of European Geriatric medicine Society;
board member of European union of medical specialists Geriatric medicine section.

Assoc. Prof. Dr. 沤ydr奴n臈 Visockien臈&苍产蝉辫;鈥�

President of Vilnius Society of Endcorinology;
member of Lithuanian Society of Endocrinology;
board member of Lithuanian Bioethics Committee;
member of European Association for the Study of Diabetes;
editorial board member of the journal Lietuvos endokrinologija.

Prof. D. Kalibatien臈 鈥�

head of the Department of Internal Diseases at Vilnius Clinical Hospital;
member of the Council of the Faculty of Medicine of 91桃色;
editorial board member of the journal Slauga. Mokslas ir praktika,
member of the Lithuanian Society of Gastroenterology,
member of the Lithuanian Society of Internists;
member of the Lithuanian Society of Palliative Medicine,
board member of the Society of Lithuanian Nurses with university education,
head of the self-assessment work group of Nursing Studies programmes;
head of the Nursing Bachelor鈥檚 degree final thesis Defending Committee.

Prof. V. Gaigalait臈 鈥�

member of Lithuanian Society of Neurology;
member of Lithuanian Society of Stroke;
editorial board member of the journal Slauga. Mokslas ir praktika,

Prof. S. Cic臈nas 鈥�

member of the ESTS (European Society of Thoracic Surgeons);
member of the IASLC (International Association for Study of Lung Cancer);
member of the Lung Cancer Study Group EORTC (European Organization for Research and Treatment of Cancer);
board member of the Lithuanian Society of Cardiothoracic Surgeons;
editorial board member and of the journal Lithuanian Surgery;
editorial board member of the journal BSM (Biological Science Monitor), expert of malignant pleural mesothelioma issues;
member of Lithuanian Society of Pulmonology and Allergy;
board member of Lithuanian Socienty of Oncology.

Prof. N. E. Samalavicius 鈥�

President of the Lithuanian Society of Coloiproctologists;
President-elect of International Society of University Colon and Rectal Surgeons;
Editor-in-chief of the journal Lithuanian Surgery;
editorial boards member of the World Journal of Coloproctology, Annal of Coloproctology;
scientific program director of 29th biennial meeting of the International Society of Univesity Colon and Rectal Surgeons. London, UK, August 29鈥揝eptember 1, 2018.
co-chairman at the Health Ministry of Lithuania of the steering committe of the National Colorectal cancer Screening Porgram.

Assoc. Prof. V. O啪eraitien臈 鈥�

member of the world Society of Gastroenterology;
member of the Lithuanian Society of Gastroenterology,
member of the Lithuanian Society of General Practitioners,
member of Nursing Bachelor鈥檚 degree final thesis Defending Committee;
editorial board member of the journal Slauga. Mokslas ir praktika,

Assisst. Prof. S. Varvuolyt臈 鈥�

president of Lithuanian Society of General Practitioners;
country delegate of UEMO (European Union of General Practitioners/Family Physicians;
board member and country delegate of EURACT (European Academy of Teachers in GP/FM);
member of BARN (Baltic Antibiotic Resistance Collaborative Network);
independent expert consultant of The National Imunoprophylaxis Programme 2014-2018;
expert consultant family physician of the Ministry of Health of the Republic of Lithuania;
expert consultant of Experts Group for Prevention of Microorganisms Resistance for Antimicrobial treatment Development and Prevalence;
expert of Vilnius region鈥檚 Antimicrobial Resistance Inter Institutional Management Group;
expert consultant family physician of European Medical Agency;
member of Medications Reimbursement Commission.

Doctoral student R. Pileckyt臈 鈥�

member of Lithuanian Hematology association;
member of European research initiative in CLL.

MOST IMPORTANT NATIONAL AND INTERNATIONAL AWARDS RECEIVED FOR R&D ACTIVITIES

Prof. S. Cicenas:

Lithuanian Honourable Doctor鈥檚 name, signed by the Lithuanian Minister of Health;
Prime Minister鈥檚 gratitude for outstanding work;
Order of the Lithuanian Grand Duke Gediminas Knight鈥檚 Cross for outstanding work - merits to Lithuania by Lithuanian President.
Pranas Gurskas, Vytautas Kasiulevicius, Audrone Marcinkut臈 were awarded Cross of the Knight of the Order of the Lithuanian Grand Duke Gediminas by the President of the Republic of Lithuania for merits to Lithuania and medicine.

MOST IMPORTANT PARTICIPATION CASES OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

Workshops at Health Ministry and Vilnius Municipality on the topics of family medicine, health care organization and prevention programmes.
UEMO - on a regular basis actively participated in the workshops, organized by European Union of General Practitioners/Family Physicians.
EURACT - on a regular basis actively participated in the workshops, organized by European Academy of Teachers in GP/FM.
BARN - on a regular basis actively participated in the workshops within the pale of Baltic Antibiotic Resistence Collaborative Network.
Council of National cardiovascular screening program.
Council of National colorectal cancer screening program.
Central European initiative against lung cancer 鈥� workshop/ expert forum.
Oncology Virtual Interactive Advisory Board expert.
Expert in trial teams at Credevo.
Member of CELCC expert team.
As a reviewer-expert at World Journal of Surgical Oncology.
SIS (Senologic International Society) member of the Board of Directors 2016鈥�2018.

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

Regulary (5-6 times a year) lectures on lung cancer at Lithuanian television, radio stations and local newspapers.
Participation in TV, radio brodcasts, popularizing the achievements of medical science.

CLINICS OF EMERGENCY MEDICINE (since March 01, 2018)

2 Santari拧ki懦, LT-08661 Vilnius
Tel. 2365 204
E-mail:

Head 鈥揚rof. Dr. Pranas 艩erpytis

STAFF

Professor: Dr. P. 艩erpytis.
Associate professors: Dr. I. Norkien臈, Dr. A. Klima拧auskas, Dr. S. Vosylius.
Teaching assistants: Dr. R. Badaras, Dr. R. Samalavi膷ius, Dr. V. 沤ilinskait臈.
Senior researcher: Dr. R. Samalavi膷ius.
Lecturers: K. Lauru拧onis, P. Uksas, A. Ignotas, B. Markevi膷, A. Zubrickas, A. Tamo拧i奴nien臈.
Doctoral students: P. Uksas, A. Briedis.

RESEARCH AREAS

Emergency Medicine
Acute Cardiac Care
Resuscitation
Politraum
Triage

OTHER SCIENTIFIC ACTIVITIES

Prof. P. 艩erpytis 鈥�

member of the Reseach Council Committee of Natural and Technical Sciences,
editorial board member of the journal Sveikatos mokslai;
scientific board member of the journal Emergency Medicine Service;
editorial board member of the journal International Heart and Vascular Disease Journal;
editorial board member of the journal Annals of Medical Case Reports;
President of the meeting of the 6th International Meeting on Acute Cardiac Care and Emergency Medicine, September 14鈥�15, 2018.

MOST IMPORTANT PARTICIPATION CASES OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

Prof. P. 艩erpytis:

Working groups of the Lithuanian Ministry of Health:

Lithuaniann Health Ministry working group of law number V-208 鈥淔or ratification of the emergency medicine care and emergency medicinine service provision order and extent鈥�;
Working group of Emergency medicine service for traumas and other external conditioned injuries (Trauma cluster).
Working group of 鈥淔ormation health supervision administrative comity for integrated pathologies in health supervision control council for cardiology, oncology, stroke and perinathology鈥� (Cardiology cluster).
Working group for use of ECMO system in emergency medicine service.

Dr. R. Samalavi膷ius:

working groups of the Lithuanian Ministry of Health: for use of ECMO system in emergency medicine service.

INSTITUTE OF ODONTOLOGY

115 沤algirio, LT-08217 Vilnius
Tel. 272 7589
E-mail:

Head 鈥� Prof. Dr. Vytaut臈 Pe膷iulien臈

STAFF

Professors: Dr. V. Pe膷iulien臈, Dr. A. P奴rien臈, Dr. T. Linkevicius.
Associate professors: Dr. R. Manelien臈, Dr. L. Zaleckas (part-time), Dr. V. Rutk奴nas, Dr. S. Drukteinis, Dr. V. Brukiene, Dr. L. Linkevi膷ien臈, Dr. R. Bendinskait臈.
Assistants: Dr. D. Ivanauskait臈 (part-time), Dr. V. Janulyte (part-time), Dr. E. Mili奴nien臈, G. Naujokaityte (part-time), E. Nedzinskiene (part-time).
Junior assistants: L. D啪iaugyt臈, A. Geciauskaite, I. Gendvilien臈, A. Rimkevi膷ius (part-time), R. Trumpait臈-Vanagien臈 (part-time), V. Zaleckiene (part-time).
Lecturers: Dr. R. Zaliuniene (part-time), Dr. R. Almonaitiene, V. Almonaitis (part-time), R. Pletkus (part-time), D. Janavi膷iene (part-time), G. Krukonis (part-time), D. Matkevicius (part-time), J. 沤ekonien臈 (part-time).
Doctoral students: L. D啪iaugyt臈, I. Gendvilien臈, S.K. Zukauskas, A. Geciauskaite, R. Borusevicius, A. Rovas.
Students鈥� scientific group of Odontology: scientific leader 鈥� Assoc. Prof. Dr. V. Brukien臈, Coordinator 鈥� student G. Vitosyt臈; 61 members of the group.

RESEARCH INTERESTS

Etiopathogenesis, diagnostics, treatment, rehabilitation and prevention of stomatognatic system disease: fundamental and clinical research.

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Evaluation of Prevalence, Treatment Methods Modalities, Rehabilitation and Prevention of Patients with Congenital and Acquired Diseases of Stomatognathic System. Prof. V. Pe膷iulien臈, Prof. A. Puriene, Prof. T. Linkevicius, Assoc. Prof. V. Rutkunas, Assoc. Prof. V. Brukiene, Assoc. Prof. L. Linkeviciene, Assoc. Prof. S. Drukteinis. 2014鈥�2018.

The holistic aim of the project is to evaluate the prevalence of congenital and acquired stomatognathic system diseases and to select the most effective methods of treatment and prevention with novelty approach, to examin attitude of patients and dentists towards the quality of dental treatment procedures, to implement dental health behaviour modification in adolescents. Regeneration therapy could open new perspectives in dentistry therefore bone regeneration enhancement together with current advances in tissue engineering and developed synthesis methods to produce composite materials (CM) with applications for bone regeneration are goal of group of research projects performed in institute. Successful root canal treatment is determined by many factors. The canal filling may be complicated when procedural errors occur, resulting in voids and unsatisfactory three-dimensional seal therefore evaluation of behaviour of newest materials in such situations using micro-CT is performed.

Periodontology

The Association of Epigenetic Factors with the Etiopathogenesis and Clinical Status of Periodontal Diseases and Rheumatoid Arthritis. Prof. A. Puriene, PhD studenr. A. Rovas.

Rheumatoid arthritis (RA) and chronic periodontitis (CP) are similar in terms of pathogenesis as both diseases involve chronic inflammation fuelled by pro-inflammatory cytokines, connective tissue breakdown and bone erosion. Multiple researches reveal associations between the diseases, including clinical, epidemiological and other aspects. The emerging importance of epigenetic regulation in the etiopathology of various diseases was the rationale for current research which aims to assess micro-RNA role in inflammation related to chronic periodontitis for patients diagnosed with CP and RA.

Preventive dentistry, cariology

Theory-Based Interventions for Improving Oral Self-Care Ii 15-16 Years Old Schoolchildren. Prof. V. Peciuliene, Assoc. Prof. V. Brukiene, PhD student. L. Dziaugyte.

Medical interventions guided by psychological theories have been effective in reducing risk behaviours and disease levels in different settings and population groups. Targeting adolescent cohorts for health promotion is important due to the fact that adults who maintained their oral health lifestyle from adolescence through adulthood presented with better oral health than the ones who had a poorer health-related lifestyle in their adolescence. Main hypothesis of research is the theory guided interventions are superior to a one-time conventional dental instruction for improving and sustaining oral self-care in adolescents.

Main publication:

Aleksej奴nien臈, J., Brukien臈, V. 2018. A cluster randomized theory-guided oral hygiene trial in adolescents 鈥� a latent growth model. International Journal of Dental Hygiene, vol. 16, no 2, e23-e30, doi: 10.1111/idh.12286.

Salivary Factors and Caries in Family Members. Preparation of Patients with Childhood Autism for Dental Procedures: Assessment of Possibilities. Oral Health and Dental Treatment Needs of Children with Cerebral Palsy in Vilnius City. Assoc. Prof. V. Brukiene.

Evaluation of the possibilities to prepare patients diagnosed with childhood autism for dental procedures is important. The goals are to reveal and to assess the prognostic criteria for possibilities of the child with autism to cooperate during dental procedures according to clinics of autism, patient developmental abilities and skills; to evaluate the effectiveness of behavioural management methods based on accomplishment of repeated tasks.

Main publication:

Aleksej奴nien臈, Jolanta; Brukien臈, Vilma. 2018. A cluster randomized theory-guided oral hygiene trial in adolescents - a latent growth model. International Journal of Dental Hygiene, vol. 16, no 2, e23-e30, doi: 10.1111/idh.12286.

Epidemiological Oral Health Survey in Lithuania. Assoc. Prof. R. Bendinskait臈, Prof. A. P奴rien臈.

Epidemiological oral health survey aims to collect data regarding the distribution of different oral conditions and their determinants in key age groups in different regions of Lithuania and to compare present findings with the results of the adult Lithuanian survey done in 1997/1998.
National oral health survey is a cross-sectional study, which take place in 15 geographic locations. Now we have data from 1300 children and adolescence and 1400 adults.

Endodontics

Characterization and Sealing Ability of the Flowable Bioceramic Materials. Assoc. Prof. S. Drukteinis, Prof. V. Pe膷iulien臈.

The aims of the studies performed are to develop flowable bioceramic material mta flow, using scanning electron microscopy (sem), energy dispersive spectroscopy (eds) and x-ray diffractometry; to evaluate and compare the root canal sealing quality by mta flow and bioroot rcs/single-cone technique in artificially perforated roots of mandibular molars, using micro computed tomography (渭ct) and to evaluate and compare the effect of ultrasound agitation on the porosity of the flowable bioceramic materials, using micro computed tomography (渭ct).

Evaluation of Procedural Errors Frequency during Endodontic Treatment and their Influence on Tooth Prognosis. Prof. V. Peciuliene, Lect. G. Naujokaityt臈, Assoc. Prof. S. Drukteinis.

The aim of this project is to evaluate the incidence of endodontic treatment errors, the impact of endodontic treatment outcomes, the prognosis and the possibility of correcting these procedural errors. This study uses clinical microscope that has become an integral part of the endodontic treatment and can affect both the endodontic treatment outcome and the tooth prognosis. The study should help to identify the most common errors in the preparation of endodontic cavity and mechanical root canal cleaning, the causes of their occurrence and how the number of these procedural errors could be reduced.

Main publication:

Drukteinis, S., Pe膷iulien臈, V., Dummer, P.M.H., Hupp, J. 2018. Shaping ability of BioRace, ProTaper NEXT and Genius nickel-titanium instruments in curved canals of mandibular molars: a MicroCT study. International Endodontic Journal, vol. 52, iss. 1, p. 86鈥�93, doi: 10.1111/iej.12961.

Dental Trauma Experience, Attitudes and Trauma Prevention in 11 to 13 Year-Old Lithuanian Schoolchildren. J. Assist. V. Zaleckien臈, Prof. V. Pe膷iulien臈.

The aim of this study was to identify the prevalence and determinants of dental trauma in permanent anterior teeth among 11- to 13-year-old schoolchildren, to compare self-reported dental trauma rates with clinical examination trauma rates, and to examine mouth guard use among children engaged in contact sports. A probability sampling scheme was used to recruit schools, with all sixth grade children in the selected schools invited to participate.

Main publication:

Zaleckien臈, V., Pe膷iulien臈, V., Brukien臈, V., Jakaitien臈, A., Aleksej奴nien臈, J., Zaleckas, L. 2018. Knowledge about traumatic dental injuries in the permanent dentition: a survey of Lithuanian dentists. Dental Traumatology, vol. 34, no 2, p. 100鈥�106, doi: 10.1111/edt.12388.3.

Prosthetic Dentistry, Biomaterials

Mechanical Wear and Bioavailability of Prosthetic Cement Materials. J. Assist. R. Trumpaite-Vanagiene, Prof. A. Puriene.

The work objective is to study in vitro model the wear and tear of cementitions substances used in dentistry practice and their bioavailability with periodontium. To investigate the resistance of wearing teeth cementing materials to the wear and the effect of the edge precision of the protrusion on wear intensity. To carry out a quantitative analysis of the cytotoxicity of dental cementation agents in human gum fibroblasts. Carry out a qualitative analysis of the cytotoxicity of dental cementation in human gum fibroblasts. Determine the primary mechanism of cement cell death.

Main publication:

Trumpait臈-Vanagien臈, R., 膶ebatari奴nien臈, A., Tunaitis, V., P奴rien臈, A., Pivori奴nas, A. 2018. Live cell imaging reveals different modes of cytotoxic action of extracts derived from commonly used luting cements. Archives of Bral biology, vol. 86, p. 108鈥�115, doi: 10.1016/j.archoralbio.2017.11.011.

In Vivo and in Vitro Accuracy Evaluation of Digitally Made Impressions and Restorations on Dental Implants. Assoc. Prof. V. Rutk奴nas, PhD student. A. Ge膷iauskait臈.

The aim is to evaluate factors influencing accuracy of digital implant impressions and restorations. Digital technologies have revolutionised clinical prosthodontics, extending diagnostic, treatment and follow 鈥� up possibilities. Digital workflow is still susceptible to errors, which can come from the digital impression and cad/cam software or production process, so one of the main goals is to improve the accuracy of digital workflow and to achieve aesthetic and functional restorations with minimal effort. Due to constant changes in intraoral scanners hardware and software, reliable methodology and clinical guidelines should be provided.

Comprehensive Evaluation of Factors Influencing the Accuracy of Digital Workflow. Assoc. Prof. V. Rutk奴nas.

The aim is to evaluate implant-supported restoration misfits occurring during the digital workflow and to investigate methods aimed at detection of the misfit. The separate steps of the digital workflow will be anlysed, trying to identify the steps most susceptible to the errors. This will help to identify better the clinical indications of fully digital and combined digital/analogue workflows. Based on the findings, the solutions helping to increase potential of digital technologies in prosthodontics will be offered.

Crestal Bone Stability around Implants with Platform Switching, Soft Tissue Thickening, Titanium Bases and Zirconium Oxide Restorations. Prof. T. Linkevicius, PhD student S.K. Zukauskas.

Vertical soft tissue thickness has been shown to be a critical factor in crestal bone stability. Several methods are proposed to increase soft tissue thickness. However, only implants with platform switching can be submerged below the bone. Alternately, implants without platform switching cannot be placed deep in the bone, as connection instability will cause bone loss. The purpose of the study is to evaluate, if subcrestal position of implant with platform switching and later restoration with screw-retained zirconia based implant supported restorations, will reduce bone loss in thin tissue biotype patients.

Main publication:

Linkevi膷ius, T., Linkevi膷ius, R., Alkimavi膷ius, J., Linkevi膷ien臈, L., Andrijauskas, P., Pui拧ys, A. 2018. Influence of titanium base, lithium disilicate restoration and vertical soft tissue thickness on bone stability around triangular-shaped implants: A prospective clinical trial. Clinical Oral Implants Research, vol. 29, no. 7, p. 716鈥�724, doi: 10.1111/clr.13263.

Orthodontics

Enamel Changes after Removal of Metal and Ceramic Braces. Assoc. Prof. L. Linkeviciene.

The aim of the study is to evaluate and compare emcs characteristics (severity, direction, location, length, and width) before and after removal metal and ceramic brackets from the teeth of the younger and older age groups. Extracted human maxillary premolars were included in the study. The teeth were extracted for orthodontic reasons or periodontal pathology from two groups of patients: younger age group (age range, 18-34 years), and older age group (age range, 35鈥�54 years).

Main publication:

Dumbryt臈, I., V臈brien臈, J., Linkevi膷ien臈, L., Malinauskas, M. 2018. Enamel microcracks in the form of tooth damage during orthodontic debonding: a systematic review and meta-analysis of in vitro studies. European Journal of Orthodontics, vol. 40, p. 1鈥�13, doi: 10.1093/ejo/cjx102.

Maxillo-facial surgery, oral surgery, oral pathology

Prospective Randomised Long-term Three-Centre Study of the Baltic Cleft Network (Rostock, Germany; Ryga, Latvia and Vilnius, Lithuania): Appearance of Lip and Nose in Patients with Unilateral Clefts of Lip, Alveolus, and Palate. Assoc. Prof. L. Zaleckas.

The aim of this study was to compare long-term results of three different cleft treatment protocols treating patients with unilateral complete clefts of lip, alveolus and palate. The standardized clinical photographies of patients had been taken according to one and the same protocol in that centre where the patient had been treated. The treatment protocols varied among these centres regarding techniques and timing. Photographies were taken before surgery and at the age of 5 and 10 years. The evaluation of function and aesthetics of the lip as well as of symmetry and harmony of the nose in 5-year-old and 10 -years old onsecutive patients was done. Evaluation was done two times according to the protocol by experienced maxillofacial surgeons on two consecutive days. The results of this evaluation will analysed statistically for significant differences.

Main publication:

Neverauskien臈, A., Maciusovi膷, M., Burkanas, M., Gricien臈, B., Petkevi膷ius, L., Zaleckas, L., Tamo拧i奴nas, A. E., Venius, J. 2018. Image based simulation of the low dose computed tomography images suggests 13鈥痬As 120鈥痥V suitability for non-syndromic craniosynostosis diagnosis without iterative reconstruction algorithms. European Journal of Radiology, vol. 105, p. 168鈥�174, doi: 10.1016/j.ejrad.2018.06.005.

Early Cleft Care Training Programme. Assoc. Prof. L. Linkeviciene.

In Europe, one in 700 pregnancies is affected by orofacial cleft. The ultimate aim is that affected individuals in different European countries will receive equal access and quality of care. Thus, the objective is to develop a training package for healthcare professionals that equips them with the knowledge and skills to make an accurate diagnosis, provide specialist early feeding advice and assessment, provide appropriate information and support to the family and establish a structured care pathway in the early months for the children with orofacial cleft.

National Research Projects

Lithuanian Research Council. Construction of Composite Bone Scaffold Material and in Vivo Evaluation of Biocompatibility and Osteopromotion. Nr. NKPDOKT-15078. Assoc. Prof. V. Rutk奴nas, PhD student I. Gendviliene.

The aim was to evaluate effectiveness of innovative 3D printed composite scaffolds in in vitro and in vivo studies on bone regeneration. Bone regeneration is a complex, well-orchestrated physiological process of bone formation, which can be seen during normal fracture healing, and is involved in continuous remodelling throughout adult life. However, there are complex clinical conditions in which bone regeneration is required in large quantity, such as for skeletal reconstruction of large bone defects created by trauma, infection, tumour resection and skeletal abnormalities, or cases in which the regenerative process is compromised, including avascular necrosis, atrophic non-unions and osteoporosis. Biology, material science and regenerative medicine, searching for a new bone graft material to change the autogenous bone.

Accuracy of Digitally Planned Implant Placement and Cad/Cam Immediate Prosthesis. Nr. KD-16137. Assoc. Prof. V. Rutk奴nas, PhD student. R. Borusevi膷ius.

The aim was to evaluate accuracy of guided implant placement and possibilities to produce digital immediate restorations. Digital treatment planing and3D technologies are becoming routine in dental practice. Cone beam computed tomography (cbct), intraoral scanners, computer-aided design and manufacturing (cad/cam), 3D printing has changed dental practice/dentistry. Prosthetic and implant dentistry employs these innovations to improve treatment accuracy, outcomes and patient satisfaction. Novel dental implantation standards require evaluation of various aspects, such as hard and soft tissue condition, prosthesis position. All these aspects have to be taken into account when planning the position of dental implants. The aim of this doctoral thesis is to evaluate the accuracy as well as biological, technical and clinical aspects of digitally planned dental implantation and immediate prosthodontics rehabilitation.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Center for Physical Sciences and Technology (Lithuania)
University of British Columbia, Vancouver (Canada)
Institute of Biotechnology, 91桃色 (Lithuania)
Institute of Biochemistry, 91桃色 (Lithuania)
Laser Research Center, 91桃色 (Lithuania)

OTHER SCIENTIFIC ACTIVITIES

Prof. V. Pe膷iulien臈 鈥�

board member of the International Association of Dental Research, NOF section;
member of the Association of Dental Education in Europe;
member of the Council of the Faculty of Medicine;
member of the Scientific Committee of the Faculty of Medicine;
chair of the Doctoral Committee of Odontology the Faculty of Medicine;
member of Study Committee in the Institute of Odontology, Faculty of Medicine, 91桃色;
member of study committee of European Society of Endodontists;
editorial board member of the journal Stomatologija (Dentistry);
editorial board member of the European Journal of General Dentistry;
editorial board member of the journal Acta Medica Lituanica;
editorial board member of the journal Health Sciences;
participation of the organizing committees of international meetings: The annual meeting of Lithuanian Society of Endodontists 2018;
expert of the Lithuanian Business Support Agency (LVPA).

Prof. A. P奴rien臈 鈥�

editorial board member of the journal Stomatologija (Dentistry);
editorial board member of the journal Dental and Medical Problems;
editorial board member of the journal Health Sciences;
member of Lithuanian society of Periodontology;
president of Lithuanian society of Ergonomics;
member of ESDE European Society of Dental Ergonomics;
member of EADPH European association of dental public health;
member of Academy of Osseointegration;
member of the Doctoral Committee of Odontology of the Faculty of Medicine.

Assoc. Prof. V. Rutk奴nas 鈥�

president of Lithuanian Society of Prosthodontics;
international relation committee member of European Prosthodontic Association;
council member of European Prosthodontic Association;
digital Dentistry Society, Ambassador to Lithuania;
editorial board member of the European Journal of Prosthodontics and Restorative Dentistry;
editorial board member of Stomatologija, Baltic Maxillofacial and Dental Journal;
expert of the Agency for Science, Innovation and Technology (MITA);
member of Study Committee in the Institute of Odontology, Faculty of Medicine, 91桃色;
member of postgraduates Study Committee in the Institute of Odontology, Faculty of Medicine, 91桃色;
participation of the organizing committees of international meetings: The annual meeting of Lithuanian Society of Prosthodontics 2018; International students and residents conference REST 2018.

Assoc. Prof. V. Brukien臈 鈥�

editorial board member of the journal Stomatologija (Dentistry), Baltic Dental and Maxillofacial Journal,
editorial board member of the journal Slauga. Mokslas ir praktika (Nursing. Science and Practice;
Lithuanian Dental Chamber, Vice-president;
chair of Study Committee in the Institute of Odontology, Faculty of Medicine, 91桃色;
member of postgraduates Study Committee in the Institute of Odontology, Faculty of Medicine, 91桃色.

Assoc. Prof. L. Zaleckas 鈥�

member of Association of Oral and Maxillofacial surgeons of Lithuania, member of council;
member of Baltic Association of Maxillofacial and Plastic Surgeons;
member of European Association for Cranio-Maxillo-Facial Surgery;
editorial board member of the journal Baltic Dental and Maxillofacial Journal;
member of Study Committee in the Institute of Odontology, Faculty of Medicine, 91桃色;
member of postgraduates Study Committee in the Institute of Odontology, Faculty of Medicine, 91桃色.

Assoc. Prof. S. Drukteinis 鈥�

member of the Research Committee of the European Society of Endodontology;
president of the Lithuanian Endodontic Society;
member of Study Committee in the Institute of Odontology, Faculty of Medicine, 91桃色;
chair of postgraduates Study Committee in the Institute of Odontology, Faculty of Medicine, 91桃色;
agency for Science, Innovation and Technology (MITA);
expert of research projects in dentistry;
European Commision. The Research Executive Agency (REA). Expert of research projects in dentistry and medicine.

MOST IMPORTANT NATIONAL AND INTERNATIONAL AWARDS RECEIVED FOR R&D ACTIVITIES

Professor Irena Bal膷i奴nien臈, Meritorious Lithuanian doctor and Lithuanian health worker, a former long-time leader VU Dental Clinic, VU Faculty of Medicine, Odontology Institute, was awarded the Officer Cross of the Lithuanian Grand Duke Gediminas Order.

INSTITUTE OF HEALTH SCIENCES

DEPARTEMENT OF REHABILITATION, PHYSICAL AND SPORTS MEDICINE

2 Santari拧ki懦, LT-08661 Vilnius, Lithuania
Tel.: 250 1323, 869771123
E-mail:

Head 鈥� Prof. Dr. Juozas Raistenskis

Professors: Dr. J. Raistenskis, Dr. V. Alekna, Dr. R. Dadelien臈, Dr. M. Tamulaitien臈, Dr. J. Gri拧kevi膷ius .
Associate professors: Dr. A. Adomavi膷ien臈, Dr. L. Samsonien臈, Dr. A. 艩idlauskien臈, Dr. R. 沤ilinskien臈, Dr. J. Armonien臈.
Assistants: Dr. J. Indri奴nien臈, Dr. I. E. Jamontait臈, Dr. A. Mastavi膷i奴t臈, Dr. I. Muntianait臈, Dr. J. Petrulyt臈.
Research assistants: A. Grigonyt臈, J. Bla啪evi膷ius, R. Sinkevi膷ius, A. 膶ernovas.
Lecturers: L. Au膷ynien臈, T. Bal膷ius, D. Barzinskas, A. Bud臈jien臈, L. Budrien臈, A. Cirtautas, E. Jablonskyt臈, J. Kesien臈, R. Kulikauskait臈, L. Mikul臈nait臈, T. Pal拧yt臈, M. Grybauskait臈, A. Juodyt臈, V. Struk膷inskait臈, J. Kup膷i奴nas, O. Ra拧imait臈, T. Grit臈nien臈, S. Buklien臈, D. 艩atkut臈, A, R.Venskaitis, Dr. R. Gulbinas, Dr. A. Valiulis.
Doctoral students: T. Auk拧tikalnis, A. Grigonyt臈, G. Narmontait臈, I. Streik臈, R. Sinkevi膷ius.
Students鈥� scientific group of Rehabilitation, physical and sports medicine: scientific leader 鈥� Lect. T. Pal拧yt臈, coordinators 鈥� student R. Gerdaityt臈, Student M. Gau拧yt臈; 19 members of the gourp.

RESEARCH INTERESTS

Biopsychosocial model
Effectiveness of rehabilitation, physical and sport medicine
Components of physical capacity
Prevention of disease and injury

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Prognostication of Comprehensive Rehabilitation Effectiveness in Patients with Movement Dysfunction. Prof. J. Raistenskis. 2014鈥�2018.

The aim of this research is to search comprehensive rehabilitation effectiveness prognostication parameters; to prepare methodology of comprehensive rehabilitation prognosis in patients with movement disturbances; to perform comparable examination of comprehensive rehabilitation prognostication, using functional status evaluation. The staff of the Department continued performance of comparable examination and methodology development of comprehensive rehabilitation effectiveness prognostication. On the base of these data, six articles were published in Clarivate Analytics database, one doctor theses was defend, and research workers took part at international and in Lithuanian scientific meetings, total 66 presentations. Students participated at international students鈥� conferences.

Main publications:

Alekna, V., Kilaite, J., Mastaviciute, A., Tamulaitiene, M. 2018. Vitamin D level and activities of daily living in octogenarians: cross-sectional study. Front Endocrinol, vol. 9, art. no 326, p. 1鈥�5, doi: 10.3389/fendo.2018.00326.

Slivovskaja, I., Ryliskyte, L., Serpytis, P., Navickas, R., Badarien臈, J., Celutkiene, J., Puronaite, R., Ryliskiene, K., Cypiene, A., Rinkuniene, E., Sileikiene, V., Petrauskiene, B., Juocevicius, A., Laucevicius, A. 2018. Aerobic training effect on arterial stiffness in metabolic syndrome. The American Journal of Medicine, vol. 131, no 2, p. 148鈥�155, doi: 10.1016/j.amjmed.2017.07.038.

Daunoravi膷ien臈, K., Adomavi膷ien臈, A., Grigonyt臈, A., Griskevi膷ius, J., Juocevi膷ius, A. 2018. Effect of robot-assisted training on upper limbs functional recovery during rehabilitation of post-stroke patients. Technology & Health Care, vol. 26, no. S2, p. 533鈥�542, doi: 10.3233/THC-182500.

MAIN RESEARCH, DEVELOPMENT AND INNOVATION PARTNERS

R墨ga Stradi艈拧 University, Faculty of Rehabilitation (Latvia)
Haapsalu Neurological Rehabilitation Centre (Estonia)
Karolinska Institute (Sweden)
Notwill Rehabilitation Centre (Switzerland)
Hannover medical school (Germany)

OTHER SCIENTIFIC ACTIVITIES

Prof. J. Raistenskis 鈥�

head of the Rehabilitation studies programme committee at the Faculty of Medicine of 91桃色;
editorial board member of the journals Gerontologija (Gerontology), Polish Annals of Medicine;
board member of Association of Physical Medicine and Rehabilitation Physicians;
member of the Association of Acupuncture, Manual and Traditional Medicine Physicians;
board member of scientific and organizing committee of the 21st European Congress of Physical & Rehabilitation Medicine, May 1鈥�6, 2018, Vilnius, Lithuania

Prof. V. Alekna 鈥�

editor-in-chief of the journal Gerontologija (Gerontology);
president of Lithuanian Association of Gerontology and Geriatrics;
president of Lithuanian Osteoporosis Foundation;
board member of UEMS Geriatric Section;
board member of European Geriatric Medicine Society (EUGMS).

Prof. M. Tamulaitien臈 鈥�

editorial board member of the journal Gerontologija (Gerontology).

Prof. R. Dadelien臈 鈥�

editorial boards member of the journals: Biology of Exercises; Journal of Physical Education and Human Movement; Sporto mokslas (Sport Science);
member of study comity, coordinator of the Rehabilitation study program;
member of European Sport Science College;
member of Lithuanian Olympic Academy;
member of LNOC group (scientist, consultant) for preparation sportsmen for 2020 and 2022 Olympic games.

Prof. J. Gri拧kevi膷ius 鈥�

editorial board member of the journal Technology & Health Care, the Netherlands;
member of study committee, coordinator of the Biomechanics and Biomedical Engineering study programs at VGTU;
scientific council member of the Faculty of Mechanics, VGTU;
member of European Society of Biomechanics;
president of Lithuanian Society of Biomechanics;
general secretary of non-profit association Educating Students in Engineering and Medicine (www.esem.eu);
chairman of organizing committee of International conference BIOMDLORE ().

Assoc. Prof. A. Adomavi膷ien臈 鈥�

chairman of the Occupational Therapy Undergraduate studies programme committee;
member of ENOTHE;
member of Lithuanian Occupational Therapy Association.

Assoc. Prof. A. 艩idlauskien臈 鈥�

the invited reviewer of the international journal Polish Annals of Medicine;
board member of Lithuanian Physiotherapy Association.

Assoc. Prof. R. 沤ilinskien臈 鈥�

co-opted member of Executive Committee of European Network of Academic Sport ();
member of the Executive Committee of Lithuanian Student Sport Association.

Assoc. Prof. L. Samsonien臈 鈥�

member of the Team Publons: Public Health and Health services;
member of International Council for Physical Activity and Fitness Research (ICPA);
member of Lithuanian Association for Adapted Physical Activity.

Assoc. Prof. J. Armonien臈 鈥�

member of Lithuanian Athletic Federation;
member of Lithuanian Physical Education Teachers鈥� Association;
evaluation expert of teachers鈥� qualification. (Physical Education).

Assist. I. E. Jamontait臈 鈥�

chairman of the Physiotherapy Undergraduate studies programme committee;
board member of Lithuanian Physiotherapy Association.

Assist. A. Mastavi膷i奴t臈 鈥�

member of the board of Lithuanian Gerontologists and Geriatrics association;
member of European Academy for Medicine of Ageing;
editorial board member and managing editor of the journal Gerontologija,

Assist. J. Petrulyt臈 鈥�

chairman of Society of Social Pediatrics of Lithuania.

Assist. I. Muntianait臈, Assist. J. Indri奴nien臈 鈥�

members of study programs committee.

DEPARTMENT OF NURSING

21 膶iurlionio, LT-03101 Vilnius, Lithuania
Tel. 23 98755
E-mail:

Head 鈥� Prof. Dr. Natalja Fatkulina

STAFF

Professor: Dr. N. Fatkulina.
Associate professor: Dr. A. Gradauskas.
Assistants: Dr. A. Mikali奴k拧tien臈, Dr. R. Stund啪ien臈 (part-time), Dr. Z. Gierasimovi膷 (part-time).
Junior assistant: V. Kielait臈 (part-time).
Lecturers: J. Gim啪auskien臈 (part-time), N. Jerdiakova (part-time).
Doctoral student: V. Kielait臈.
Specialist: E. Kuzien臈.

RESEARCH INTERESTS

Quality of nursing care
Nursing needs of patients with internal, surgical, mental, children鈥檚 diseases Nurse Competences
Nursing education
Empowered patient education

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

The Evaluation of Nursing Needs and Quality of Life and Perfection of Health Care and Education of Patients. Prof. D. Kalibatien臈. 2014鈥�2018.

Nursing specialty students鈥� approach to learning and future prospects was evaluated and the nursing students鈥� opinion about the organization of the practical training process assessed. 164 nursing students participated in the research. The role of nurses in the field of prevention of communicable diseases in health care institutions was evaluated; postoperative complications of neurosurgical with onco-hematological patients and nursing services. 30 patients after spinal neurosurgical operations and 36 onco-haematologic patients after stem cell transplantation were examined. Need of care of these patients after those operations was evaluated.

National Reseach Projects

Health and Harmony for Every Student. Ministry of Education and Science, Lithuanian Republic. Project Leader Prof. N. Fatkulina. 2017鈥�2018.

The aim was to sustain and develop the health literacy of students and to improve their knowledge and skills of health, to improve the national and international identification of student by using informal methods in order to promote healthy life style.

Main publications:

Emeljanovas, A., Mieziene, B., Gruodyte-Raciene, R., Sukys, S., Rutkauskaite R., Trinkuniene, L., Fatkulina, N., Gerulskiene, I. 2018. Results from Lithuania鈥檚 2018 Report Card on Physical Activity for Children and Youth. Journal of Physical Activity & Health, vol. 15, suppl. 2, S382鈥揝383, doi: 10.1123/jpah.2018-0505.

Emeljanovas, A., Mieziene, B., ChingMok, M.M., Chin, M., Cesnaitiene, V.J., Fatkulina, N., Trinkuniene, L., Sanchez, G.F.L., Suarez, A.D. 2018. The effect of an interactive program during school breaks on attitudes toward physical activity in primary school children. Anales de psicologia/Annals of psychology, vol. 34, no. 3, p. 580鈥�586, doi: 10.6018/analesps.34.3.326801.

Charalambous, A., Papastavrou, E., Valkeap盲盲, K., Zabalegui, A., Ingadottir, B., Lemonidou, C., Fatkulina, N., Jouko, K., Leino-Kilpi, H. 2018. Content of Ortopedic Patient Education Provided by Nurses in Seven European Countries. Clinical Nursing Research, vol. 27, iss. 7, 770-789; doi: 10.1177/1054773817713178.

International Research Projects

Professional Competence in Nursing (PROCOMPnurse). Lead - partner University of Turku (UTU), Faculty of Medicine, Dpt of Nursing Science, Turku,

Finland, project leader - Professor Helena Leino-Kilpi, In Lithuania 鈥� Prof. N. Fatkulina. 2017鈥�2021.
Research project鈥檚 aim is to produce and evaluate instruments assessing competence and factors connected, both self-assessment and objective tests and to establish a cohort for follow-up studies in future, responding to the need for longitudinal studies.

Erasmus + strategical partnership, project: Nursing Leadership Educational Program for Doctoral and Postdoctoral Nurses (NURSE-LEAD). Project leader 鈥� Thora B. Hafsteinsd贸ttir, University of Island, In Lithuania 鈥� Prof. N. Fatkulina. 2017鈥�2019.

The project aims are directing doctoral nursing students and postdoctoral nurses into an academic career in nursing by providing them with opportunities to expand their educational, research and leadership competencies. Thus the project will attune nursing education into emerging labor market鈥檚 needs.

Baltic Sea Region Network in Personalized Health Care, Interreg Baltic Sea Region project leader (coordionator 鈥� Professor Helena Leino-Kilpi, leading scientists in Lithuania 鈥� Prof. N. Fatkulina. 2017鈥�2018,

The aim is to offer doctoral students a systematically built, scientifically ambitious, and multidisciplinary research training which benefits from Baltic Sea Region contacts. It is expected the network to contribute to the further improvement of the scientific standard of personalized healthcare research and increase the number of internationally competitive experts in Baltic Sea Region. Combining data and knowledge from different areas and pooling resources will pave the way for designing novel more personalized healthcare interventions.

MAIN RESEARCH, DEVELOPMENT AND INNOVATION PARTNERS

University of Turku, Department of Nursing Science, Turku (Finland)
Health Science Research Centre, University College Lillebaelt and Southern Denmark University (Denmark)
Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Stockholm (Sweden)
University of Utrecht, Utrecht (the Netherlands)
University of Island, Reykjavik (Island)

OTHER SCIENTIFIC ACTIVITIES

Prof. N. Fatkulina 鈥�

member of European Academy of Nursing Science,
member of Association Institute of Bute;
member of the Nursing Bachelor鈥檚 Degree Program;
member of the Nursing Master鈥檚 Degree Program;
member of Nursing Bachelors鈥� degree final thesis Defending Committee;
editorial board member of the journal Slauga: mokslas ir praktika (Nursing. Science and Practice).

Assoc. Prof. A. Gradauskas 鈥�

head of the Clinic of Surgery at Vilnius city Clinical Hospital;
vice-president of Vilnius Association of Surgeons;
board member of the Lithuanian Association of Minimally Invasive Surgery,

Assist. A. Mikali奴k拧tien臈 鈥�

chair of the Lithuanian University Education Nursing Society Board,
member of the Lithuanian Society of Palliative Medicine,
member of the Nursing Bachelor鈥檚 Degree Program;
member of the Nursing Master鈥檚 Degree Program;
member of Nursing Bachelors鈥� degree final thesis Defending Committee;
editorial board member of the journal Sveikatos mokslai (Health Sciences);
editorial board member of the journal Slauga: mokslas ir praktika (Nursing. Science and Practice).

Assist. R. Stund啪ien臈 鈥�

member of the Lithuanian Society of Palliative Medicine,
member of the Nursing Bachelor鈥檚 Degree Program;
member of the Lithuanian University Education Nursing Society Board,
member of Lithuanian Nursing Specialists Organization, .

Assist. Z. Gierasimovi膷 鈥�

member of the Lithuanian Society of Palliative Medicine,
member of the Nursing Bachelor鈥檚 Degree Program;
member of the Lithuanian University Education Nursing Society Board,
editorial board member of the journal Slauga: mokslas ir praktika (Nursing. Science and Practice);
member of Nursing Bachelors鈥� degree final thesis Defending Committee.

Junior assist. V. Kielait臈 鈥�

member of the Lithuanian University Education Nursing Society Board,

Lect. J. Gim啪auskien臈 鈥�

member of the Nursing Bachelor鈥檚 Degree Program;
member of the Lithuanian University Education Nursing Society Board,
member of the Anaesthesia and Intensive Care Nurses Association;
member of Lithuanian Nursing Specialists Organization,

Lect. N. Jerdiakova 鈥�

member of the Anaesthesia and Intensive Care Nurses Association;
member of the Lithuanian University Education Nursing Society Board,

DEPARTMENT OF PUBLIC HEALTH

21/27 M.K. 膶iurlionio, LT-03101 Vilnius
Tel.: 239 8732, 239 8738

Head 鈥� Prof. Dr. Rimantas Stukas

STAFF

Professors: Dr. R. Stukas, Dr. G. 艩urkien臈, Dr. J. Dadonien臈, Dr. K. 沤agminas, Dr. A. Germanavi膷ius, Dr. E. Gefenas.
Associate professors: Dr. M. Jakubauskien臈, Dr. L. Murauskien臈, Dr. R. Buckus (part-time).
Assistants: Dr. S. Vainauskas, Dr. J. Kairys (part-time), Dr. A. Astrauskien臈 (part-time), Dr. L. A拧oklien臈 (part-time), Dr. R. Bartkevi膷i奴t臈 (part-time), A. Barzda (part-time), Dr. A. Ber啪anskyt臈, Dr. Dr. A. 膶ekanauskait臈 (part-time), N. Kuprevi膷ien臈 (part-time), Dr. R. Sketerskien臈 (part-time), Dr. A. Juodait臈鈥� Ra膷kauskien臈 (part-time), Dr. R. Vaitkien臈 (part-time), Dr. R. Jankauskas (part-time), Dr. G. Smailyt臈 (part-time), Dr. V. Taminskien臈, Dr. V. Dobrovolskij (part-time), L. Pa拧kevi膷ius (part-time), Dr. A. Bartkien臈 (part-time), Dr. A. 沤alnora, D. Austys, R奴ta Maceinait臈 (part-time), Justina Ra膷ait臈 (part-time),
Research fellows: Dr. A. Valiulis, Dr.Rolandas Zuoza.
Lecturers: Dr.M. Po拧kut臈 (part-time) Dr. A. Bagdonavi膷ius (part-time), Dr. D. Brogien臈 (part-time), Dr. M. Butikis, Dr. J. Stanislavovien臈, I. Ku拧eliauskait臈 (part-time), R. Baranauskien臈 , A. 膶epas (part-time), N. Fiodorova (part-time), V. Jaeck (part-time), V. Luka拧evi膷ien臈 (part-time), Olga Ver拧ilien臈(part-time), Algirdas 膶epas(part-time).
Doctoral students: V. Andreik臈nait臈, I. Tamulaityt臈鈥� Morozovien臈, I. Pa膷iauskait臈, A. 膶ernovas, O. Ubartien臈, D. Dudutien臈, A. Bilotien臈, A. Motiej奴nien臈, S. Grubyt臈, L. Steponavi膷ien臈, R. Maceinait臈, J. Ra膷ait臈, 沤. 沤andaras, J. Lekstutien臈, A. Pata拧ius, Ginreta Valin膷i奴t臈, Justinas Bla啪evi膷ius.
Public health scientific group of students: scientific leader 鈥� Dr. V. Dobrovolskij, coordinator 鈥� student E. Jansonas; 31 members of the group.

RESEARCH INTERESTS

Environmental and social factors and public health
History of medicine
Epidemiology of non-infectious and infectious diseases
Scientific basis of health care management
Assessment of health care activities and biostatistics
Health and quality of life
Medical ethics

RESEARCH PROJECTS CARRIED OUT IN 2018

Projects Supported by University Budget

Assessment of Health Risk Factors and Sense of Coherence of Elderly People. Prof. R. Stukas. 2014鈥�2018.

The collected data were analyzed according to the dissertation theme and scientific publications from the obtained research data were prepared (two research articles were submitted and accepted).

Main publications:

膶ernovas, A., Alekna, V., Tamulaitien臈, M., Stukas, R. 2018. Reliability and validity of the Lithuanian version of CASP-19: a quality of life questionnaire for the elderly. Medicina, vol. 54, no. 6, 103, p. 1鈥�9, doi: 10.3390/medicina54060103.

膶ernovas, A., Alekna, V., Tamulaitien臈, M., Katavici奴t臈, G., Stukas, R. 2018. Physical activity, quality of life and subjective well-being peculiarities and associations in elderly women. Health Sciences in Eastern Europe, vol. 28, no 4, p. 18鈥�24.

Prevalence Study on Unintentional Domestic Injuries among Pre-School Children. Prof. G. 艩urkien臈. 2014鈥�2018.

In 2018, statistical analysis of data about prevalence, risk and preventive factors of home related injuries among preschool children attending preschool education establishments was finished. Paper entitled Prevalence, risk and preventive factors of home-related injuries among preschool children attending preschool education establishments to the International Journal of Injury Control and Safety Promotion was prepared.

Ethical Aspects of Biomedical Reasearch with Human. Prof. E. Gefenas. 2014鈥�2018.

The aim of the project was to assess and investigate implementing Regulation (EU) No 536/2014 of the European Parliament and of the Council of 16 April 2014 on clinical trials on medicinal products for human use. The database of Bioethics Bibliography which provides brief information about articles published in Lithuanian and international journals as well as Lithuanian legislation dealing with ethical dilemmas in a number of fields was updated.

International Science Programmes, Projects and Contracts

Advanced Certificate Program: Research Ethics in Central and Eastern Europe. Prof. E. Gefenas. 2004鈥�2018.

In 2018, our Department continued collaboration with Clarkson University Bioethics Program (USA) in implementation of the project: results of collaboration with Clarkson University Bioethics Program were assessed.

ENERI 鈥� European Network of Research Ethics and Research Integrity. Prof. E. Gefenas. 2015鈥�2019.

The aim of the project is to strengthen activities of education and training in research ethics and research integrity, promote a culture of integrity, and foster the development of and compliance with joint rules and norms. In 2018 researchers of 91桃色 continued work with the main objective of the project 鈥� preparation of advanced training modules on research ethics and integrity for RECs and RIOs.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Lancaster University (UK)
Universidad de Deusto (Spain)
University of Verona (Italy)
Corvinus University of Budapest (Hungary)
Ministry of Health (Lithuania)

OTHER SCIENTIFIC ACTIVITIES

Prof. R. Stukas 鈥�

editorial college member of the journal Visuomen臈s sveikata (Public Health);
editorial board member of the journal Sveikatos mokslai (Health Sciences);
member of the Board of the Faculty of Medicine;
head of study programmes Committee for Bachelor and Master degree and PhD in Public Health;
board member of the Lithuanian Society of Hygienists and Epidemiologists.

Prof. G. 艩urkien臈 鈥�

editorial board member of the journals Visuomen臈s sveikata (Public Health); Sveikatos mokslai (Health Sciences); Vaik懦 pulmonologija ir alergologija (Paediatric Pulmonology and Allergology);
member of the Lithuanian Society of Hygienists and Epidemiologists;
chair of the Committee for Doctoral studies at 91桃色 in Public Health Areas;
member of study programmes committee for Bachelor and Master degree of Public Health.

Prof. K. 沤agminas 鈥�

editorial board member of the journals Visuomen臈s sveikata (Public Health); Medicinos teorija ir praktika (Theory and Practice in Medicine);
member of the Lithuanian Society of Hygienists and Epidemiologists;
member of the Lithuanian Association for Infectious Diseases;
member of Committee of Experts of Vaccination of Lithuanian Ministry of Health.

Prof. J. Dadonien臈 鈥�

President of Lithuanian Rheumatologist Association;
board member of Lithuanian Arthritis Association (patient organization);
member of European Network for Vasculitis Research (EUVAS);
member of organizing committee for the annual conference Vilnius Seminars in Rheumatology;
European Research programme H2020 expert for Health demographics and wellbeing committee.

Prof. E. Gefenas 鈥�

co-director of the Advanced Certificate Program in Research Ethics in Central and Eastern Europe sponsored by Clarkson University Bioethics Program (Schenectady, New York);
member of European Group on Ethics in Science and New Technologies (EGE);
member of the Council of Europe Steering Committee on Bioethics (CDBI);
member of the bureau of the European Society for Philosophy of Medicine and Health Care (ESPMH);
member of the advisory editorial board of the journals Medicine, Health Care and Philosophy: A European Journal, (Springer);
chairperson of the bureau of the Intergovernmental Bioethics Committee (IGBC).

Prof. A. Germanavi膷ius 鈥�

member of European Association of Psychiatrists;
board member of the European Network for Mental Health Service Research and Evaluation (ENMESH);
member of the Committee on History of Psychiatry, World Federation of Biological Psychiatry;
member of the Working Group in the History of Medicine, Brook University, Oxford, UK;
member of Lithuanian Psychiatric Association (LPA);
president of Lithuanian Association for Psychosocial Rehabilitation;
editorial board member of the journals Nordic Journal of Psychiatry; Medicina (Medicine);Sveikatos Mokslai (Health Sciences); Biologin臈 psichiatrija ir psichofarmakologija (Biological Psychiatry and Psychopharmacology);
member of committee for strategic planning of mental health care development in Lithuania 2008鈥�2013 at the Ministry of Health.

Assoc. Prof. Dr. M. Jakubauskien臈 鈥�

vice president of the Public Mental Health Section of the European Public Health Association (EUPHA);
member of the International Scientific Committee of the European Public Health Association (EUPHA);
member of the review board of the International Society for Traumatic Stress Studies (USA);
member of the Lithuanian Association for Trauma Psychology;
member of the Lithuanian Bioethics Society;
member of the Board of Federation Global Initiative on Psychiatry;
co-leader of the International Research in Public Mental Health course.

Prof. A. Valiulis 鈥�

president of Lithuanian Paediatric Respiratory Society;
vicepresident of Lithuanian Paediatric Society;
chairman of Lithuanian Alliance Against Chronic Lung Diseases (WHO-GARD Lithuania);
vicechairman of Mother and Child Health Commission of Lithuanian Academy of Sciences;
national coordinator in Strategic Pediatric Alliance for the Child Health in Europe;
national delegate at Global Asthma Initiative (GINA) and Global Allergic Rhinitis Initiative (ARIA);
chairman of Advisory Board of Lithuanian Council of Asthma Clubs;
chief executive of IPOKRaTES Lithuania Fund;
editor-in-chief of the journal Paediatric Pulmonology and Allergology;
editor-in-chief of the journal Lithuanian Paediatric Chronicle;
editorial board member of the journals Paediatric Respiratory Reviews, Pneumonologia i Alergologia Polska, Pediatria Polska, Russian Paediatric Journal;
chairman of Vilnius International Paediatric Pulmonology Conference 鈥� School (20th annual international conferences of Paediatric Asthma, Pneumonia, CF, TB and Orphan Lung Diseases; more than 8000 trained doctors);
chairman of 4 Lithuanian National Asthma Congresses;
chairman of 3 Lithuanian Congresses on Paediatric Pulmonology;
chairman of 2 international conferences on Human Ecology;
honorary fellow of British Royal College of Paediatrics and Child Health;
member of Commissions of Rare Diseases, TB, Immunoprophylaxis, Mother & Child, Suckling, Human Resources, Accessibility of Health Service of Lithuanian Ministry of Health;
chairman of Committee of Experts of Vaccination of Lithuanian Ministry of Health;
chief Vilnius Paediatrician of the Ministry of Health of the Republic of Lithuania.

Assoc. Prof. J. Kairys 鈥�

editorial board member of the journal Sveikatos mokslai (Health Sciences).

Assoc. Prof. L. Murauskien臈 鈥�

member of Independent Expert Panel on Effective Ways of Investing in Health (European Commission, DG Health and Food Safety);
associate editor for BMC Health Services Research;
member of the Health Systems and Policies Monitoring Network, European Observatory on Health Systems and Policies;
expert for 15th Baltic policy dialogue: Ensuring universal health coverage in the Baltics: exploring policy options to improve performance, November 8鈥�9, 2018, Riga, Latvia;
expert for Health System Challenges in small European states. April 26, 2018; Brussels, Belgium.

Assist. Dr. A. 膶ekanauskait臈 鈥�

member of the Lithuanian Bioethics Society;
member of the Board of the Foundation for Patient Safety, Innovations and Quality.

Assist. R. Vaitkien臈 鈥�

deputy member of the Administrative Commission for the Coordination of Social Security Systems, European Commission, since 2009, Brussels, Belgium;
member of the intersectoral working party on implementation of United Nations 2030 Agenda for Sustainable Development in Lithuania.

Assist. R. Jankauskas 鈥�

editorial board chair of the journal Visuomen臈s sveikata (Public Health).

Assist. R. Bartkevi膷i奴t臈 鈥�

member of Lithuanian Breastfeeding Committee;
alternate representative of European Food Safety Authority Food Consumption Data Network.

Assist. R. Barzda 鈥�

representative of Republic of Lithuania in Codex Alimentarius Commision;
representative of European Food Safety Authority Food Consumption Data Network.

Assist. D. Brogien臈 鈥�

executive director of the Foundation for Patient Safety, Innovations and Quality;
member of Lithuanian Society of Ostetricians and Gynaecologists. Chair of Legal, Ethics and Competence Evaluation Commission;
member of the Board of Lithuanian Doctors Association. Chair of the Legal Commission;
board member of Lithuanian Bioethics Committee under the Ministry of Health;
vice-president of CPME (The Standing Committee of European Doctors).

Assist. A. Juodait臈-Ra膷kauskien臈 鈥�

member of European Palliative Care Association, Toekomststraat 36, 1800 Vilvoorde, Belgium.

Dr. A. 沤alnora 鈥�

member of Lithuanian Morphological Society;
member of Lithuanian Association of the History and Philosophy of Science;
editoral board member of the Acta medico-historica Rigensia.

R. Baranauskien臈 鈥�

member of European Health Management Association.

MOST IMPORTANT PARTICIPATION CASES OF RESEARCHERS IN WORKING GROUPS OR COMMISSIONS SET UP BY STATE AUTHORITIES, STATE AND MUNICIPAL INSTITUTIONS AND ORGANISATIONS, AND BUSINESS ENTITIES

The National Verification Committee on measles and rubella elimination (Chairperson, prof.dr. Kestutis 沤agminas (Faculty of Medicine Institute of Health Sciences, Department of Public Health, 91桃色).

National immunization programme 2014鈥�2018 Advisory Group on Immunisation (member, prof.dr. Kestutis 沤agminas (Faculty of Medicine Institute of Health Sciences, Department of Public Health, 91桃色).

L. Murauskiene. Leading a Working Group for Setting Priorities for Health-related Activities Financing for 2021鈥�2028. Commissioned by Consulting Company ESTEP and the Ministry of Finance.

Rima Vaitkien臈. The member of the Compulsory Health Insurance Board (Resolution No 710 of the Government of the Republic of Lithuania, 2017) and chair person of Compulsory Health Insutrance Board since 15 th of September 2017 till 11 of October 2018.

Rima Vaitkien臈. Chair person of the group for the management inprovement at the Ministry of Health of the Republic of Lithuania (Order of the Minister of Health of the Republic of Lithuania No V-880, 26 of July 2017) (till 11 of October 2018).

Rima Vaitkien臈. The member of the working group for the amendments for Lithuanian Health Strategy for 2014鈥�2025 approved by the Resolution of the Parliament of the Republic of Lithuania No XII-964, 2014 (Order of the Minister of Health of the Republic of Lithuania No V-111, 14 of January 2018.

CONSULTATIONS PROVIDED BY THE UNIT TO THE PUBLIC OR ECONOMIC ENTITIES

Rima Vaitkien臈. The presentation Structural reforms in health system and participation in discussions in scientific practical conference for heads of health care institutions of Lithuania on 18 of May 2018.

Rima Vaitkien臈. The presentation Implementaion of strategic documents and recommendations of international organisations for Lithuanian health system in the meeting of National Health Board on May 30, 2018.

Rima Vaitkien臈. The presentation Structural changes in health care institutions and participation in discussions in the meeting 鈥� conference of Council of representatives of Trade union of Lithuanian medical professionals on June 8, 2018.

MOST IMPORTANT RESEARCH DISSEMINATION ACTIVITIES

L. Murauskiene. Presentation of selected recent opinions delivered by the Expert Panel on Effective Ways of Investing in Health according to the mandates from the European Commission. Conference 鈥濩hallenges and opportunities for health care managers. Vilnius, May 17, 2018.

L. Murauskiene. Presentation of the main findings on vaccination in the EU based on the 2018 European Observatory on Health Systems and Policies report The organization and delivery of vaccination services in the European Union and the Expert Panel on Effective Ways of Investing in Health 2018 opinion Vaccination Programmes and Health Systems in the EU. 6th National Conference on Infectious Diseases. Vilnius, November 30, 2018.

沤alnora Aistis. Interview for radio station Polskie Radio dla zagranicy about physicians of the Stefan Batory University in interwar Vilnius, December 1, 2018.

沤alnora Aistis. Interview for TV show 鈥淟ietuvos kolumbai鈥� (Lithuanian Columbuses, TV station LRT) about Vilnius physicians J. P. Frank and J. Frank, May 14, 2018.

沤alnora Aistis. Interview for radio show 鈥淪konio i拧拧奴kis鈥� (鈥淐hallenge of taste鈥�, radio station 鈥溑絠ni懦 radijas鈥�) about problems of nutrition in interwar Vilnius, April 19, 2018.

沤alnora Aistis. Interview about nutrition habits in interwar Lithuania, 鈥淟ietuvos sveikata鈥�, February 15, 2018.

沤alnora Aistis. Lithuanian physicians 100 years ago. Media expresas, February 12, 2018.

MAIN SCIENTIFIC ACHIEVEMENTS IN 2018

Dr. Daiva Brogiene. Vice-president of CPME (The Standing Committee of European Doctors).